The pathobiology of the osteoclast.

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

1979 • 2,025 citations

An interleukin 1 like factor stimulates bone resorption in vitro

1983 • 1,017 citations

Prostaglandins: Stimulation of Bone Resorption in Tissue Culture

1970 • 981 citations

Fibroblast traction as a mechanism for collagen morphogenesis

1981 • 862 citations

Generation of Electric Potentials by Bone in Response to Mechanical Stress

1962 • 748 citations

Biochemical Evaluation of Patients with Cancer-Associated Hypercalcemia

1980 • 715 citations

Evidence for the Secretion of an Osteoclast Stimulating Factor in Myeloma

1974 • 681 citations

1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture

1972 • 631 citations

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications

1983 • 585 citations

Calcitonin alters behaviour of isolated osteoclasts

1982 • 509 citations

Prostaglandins as Mediators of Hypercalcemia Associated with Certain Types of Cancer

1975 • 461 citations

Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.

1983 • 424 citations

Resorption of bone by isolated rabbit osteoclasts

1984 • 423 citations

The Effect of Calcium-Regulating Hormones and Prostaglandins on Bone Resorption by Osteoclasts Disaggregated from Neonatal Rabbit Bones*

1985 • 419 citations

Calcitonin

1981 • 418 citations

Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.

1975 • 393 citations

Bone remodelling induced by physical stress is prostaglandin E2 mediated

1980 • 335 citations

In vitro formation of osteoclasts from long-term cultures of bone marrow mononuclear phagocytes.

1982 • 333 citations

The hypercalcemia of malignancy: Pathogenesis and management

1982 • 317 citations

Calcium and cAMP as synarchic messengers

1982 • 284 citations

Effects of electromagnetic stimuli on bone and bone cells in vitro: Inhibition of responses to parathyroid hormone by low-energy low-frequency fields

1982 • 283 citations

Quantitative Bone Histomorphometry in Humoral Hypercalcemia of Malignancy: Uncoupling of Bone Cell Activity*

1982 • 277 citations

Mechanisms of bone destruction in the development of skeletal metastases

1976 • 273 citations

Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man

1982 • 255 citations

Prostaglandin E2 levels and human periodontal disease

1974 • 254 citations

Direct resorption of bone by human breast cancer cells in vitro

1978 • 240 citations

Calcitonin Receptors of Kidney and Bone

1972 • 222 citations

Fate of mineralized and demineralized osseous implants in cranial defects

1981 • 220 citations

Direct in vivo demonstration by radioautography of specific binding sites for calcitonin in skeletal and renal tissues of the rat.

1980 • 210 citations

Parathyroid hormone receptor in intact embryonic chicken bone: characterization and cellular localization.

1982 • 209 citations

1,25-Dihydroxycholecalciferol and Parathormone: Effects on Isolated Osteoclast-Like and Osteoblast-Like Cells

1977 • 207 citations

Cyclic AMP and Cyclic GMP: Mediators of the Mechanical Effects on Bone Remodeling

1975 • 205 citations

The Cellular Basis of Bone Resorption

1980 • 201 citations

The Sensitivity of Isolated Osteoclasts to Morphological Transformation by Calcitonin*

1983 • 198 citations

Mouse osteoblasts synthesize collagenase in response to bone resorbing agents

1984 • 192 citations

Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins

1976 • 183 citations

Quantitative histology of myeloma‐induced bone changes

1982 • 183 citations

The origin of osteoclasts:

1983 • 172 citations

Vitamin D is not directly necessary for bone growth and mineralization

1984 • 170 citations

Rodent peritoneal macrophages as bone resorbing cells

1979 • 163 citations

Cellular kinetics of the bone remodeling sequence in the rat

1982 • 159 citations

Prostaglandin Production and Bone Resorption by Dental Cysts

1973 • 157 citations

The effects of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells

1985 • 148 citations

The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80

1985 • 147 citations

Activation of Adenosine 3',5'-Monophosphate-Dependent Protein Kinase in Normal and Malignant Bone Cells by Parathyroid Hormone, Prostaglandin E₂, and Prostacyclin*

1981 • 143 citations

Effect of substrate composition on bone resorption by rabbit osteoclasts

1984 • 142 citations

Pulsing electromagnetic fields: A new method to modify cell behavior in calcified and noncalcified tissues

1982 • 139 citations

Failure of cells of the mononuclear phagocyte series to resorb bone

1984 • 138 citations

Response of bone to tumor invasion

1956 • 125 citations

THE EFFECT OF PARATHYROID EXTRACT ON CELLULAR ACTIVITY AND PLASMA CALCIUM LEVELS IN VIVO

1969 • 124 citations

BREAST-CANCER OSTEOLYSIS, BONE METASTASES, AND ANTI-OSTEOLYTIC EFFECT OF ASPIRIN

1976 • 124 citations

Effect of Thyrocalcitonin on Adenosine 3′:5′-Cyclic Phosphate Formation by Rat Kidney and Bone

1970 • 121 citations

Macrophage-Lymphocyte Synergy in the Production of Osteoclast Activating Factor

1974 • 121 citations

The lamina limitans of the organic matrix of calcified cartilage and bone

1972 • 121 citations

Hypercalcemia Associated with T-cell Lymphoma-leukemia

1981 • 120 citations

Autoradiographic localization of target cells for 1α, 25-dihydroxyvitamin D3 in bones from fetal rats

1983 • 119 citations

Bone Cells in Culture: Morphologic Transformation by Hormones

1976 • 119 citations

Electron microscopic localization of hydrolytic enzymes in osteoclasts

1972 • 119 citations

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen f4/80: Macrophages of bone and associated connective tissue

1984 • 117 citations

Effect of parathyroid hormone and calcitonin on the cytoplasmic spreading of isolated osteoclasts

1984 • 111 citations

Stimulation of Bone Resorption by Parathyroid Hormone in Tissue Culture

1963 • 109 citations

THE PATHOLOGICAL BASIS FOR SKELETAL SCINTIGRAPHY

1975 • 109 citations

Inhibition of osteoclastic motility by prostaglandins I₂, E₁, E₂ and 6‐oxo‐E₁

1983 • 107 citations

Membrane fusion reaction: A theory

1971 • 106 citations

Cell surface characterization of the human osteoclast: Phenotypic relationship to other bone marrow‐derived cell types

1984 • 106 citations

Successful treatment of hypercalcemia by indomethacin in mice bearing a prostaglandin-producing fibrosarcoma

1973 • 97 citations

Biochemical and immunohistochemical studies on collagenase in resorbing bone in tissue culture

1982 • 96 citations

Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

1984 • 95 citations

The Origin of Osteoclasts

1982 • 95 citations

New Knowledge on the Origin, Function and Fate of Osteoclasts

1981 • 94 citations

Pharmacological control of osteoclastic motility

1983 • 94 citations

Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2

1981 • 90 citations

Urinary and Nephrogenous Adenosine 3′,5′-Monophosphate in the Hypercalcemia of Malignancy*

1981 • 90 citations

Rapid activation of the medullary bone osteoclast cell surface by parathyroid hormone.

1978 • 89 citations

Kinetics of osteoclasts and their nuclei in evolving secondary Haversian systems.

1981 • 88 citations

Prostaglandin-like material extracted from squamous carcinomas of the head and neck

1980 • 86 citations

Behavior of osteoclasts during a rapid change in their number induced by high doses of parathyroid hormone or calcitonin in intact rats

1981 • 74 citations

Phagocytosis and trypsin‐resistant glass adhesion by osteoclasts in culture

1979 • 73 citations

Role of prostaglandins in the production of hypercalcemia by tumors.

1978 • 71 citations

ACUTE EFFECTS OF CALCITONIN ON OSTEOCLASTS IN MAN

1976 • 69 citations

Parathyroid gland and bone in vitro. VI

1959 • 68 citations

Cyclo-oxygenase products of arachidonic acid metabolism in rat osteoblasts in culture

1983 • 68 citations

Osteoclast formation in vitro from bone marrow mononuclear cells in osteoclast‐free bone

1981 • 66 citations

Activity Ratio Measurements Reflect Intracellular Activation of Adenosine 3′,5′-Monophosphate-Dependent Protein Kinase in Osteoblasts*

1982 • 66 citations

Effects of prostaglandins and other drugs on the cyclic AMP content of cultured bone cells

1976 • 65 citations

RESORPTION OF BONE

1979 • 65 citations

DNA synthesis is not necessary for osteoclastic responses to parathyroid hormone in cultured fetal rat long bones.

1983 • 63 citations

Multinucleation enhances macrophage-mediated bone resorption.

1983 • 63 citations

On the origin of the osteoclast: The cell surface phenotype of rodent osteoclasts

1985 • 61 citations

Immunohistochemical Demonstration of Calcitonin Binding to Specific Cell Types in Fixed Rat Bone Tissue

1981 • 60 citations

Heberden Oration 1980: aspects of the cell biology of the rheumatoid synovial lesion.

1981 • 58 citations

When is it an osteoclast?

1984 • 57 citations

Homologous and Heterologous Control of Bone Cell Adenosine 3′,5′-Monophosphate Response to Hormones by Parathormone, Prostaglandin E2, Calcitonin, and 1,25-hydroxycholecalciferol*

1980 • 48 citations

A study of prostaglandin E2, parathormone, and response to indomethacin in patients with hypercalcemia of malignancy

1982 • 47 citations

Morphological and ultrastructural aspects of the activation of avian medullary bone osteoclasts by parathyroid hormone

1984 • 46 citations

Observations on the Mechanism of Bone Resorption Induced by Multiple Myeloma Marrow Culture Fluids and Partially Purified Osteoclast-activating Factor

1981 • 46 citations

Normal osteoid tissue

1972 • 46 citations

Periosteal Osteoclasts, Skeletal Development and Ageing

1960 • 46 citations

HYPERCALCAEMIA AND METASTATIC BONE DISEASE: IS THERE A CAUSAL LINK?

1982 • 45 citations

Cell population dynamics of periodontal ligament stimulated with parathyroid extract

1975 • 42 citations

Lack of Fc receptors on osteoclasts

1980 • 38 citations

Acute reduction in 0steoclast number during bone repletion

1982 • 37 citations

Parathyroid Hormone Stimulation of Collagenase Secretion by Isolated Bone Cells*

1979 • 34 citations

Quantitative Bone Histology in the Hypercalcemia of Malignant Disease*

1982 • 33 citations

Donor origin of the in vitro hematopoietic microenvironment after marrow transplantation in mice

1984 • 32 citations

The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis

1980 • 31 citations

Computed surface potential changes with membrane interaction

1968 • 31 citations

A factor synthesized by rabbit periosteal fibroblasts stimulates bone resorption and collagenase production by connective tissue cells in vitro

1984 • 29 citations

Effects of osteoclast activating factor from human lymphocytes on cyclic AMP concentrations in isolated mouse bone and bone cells

1979 • 29 citations

Some mechanisms of local bone destruction by squamous carcinomas of the head and neck

1981 • 28 citations

Transformations of osteoclast phenotype in ia rats cured of congenital osteopetrosis

1982 • 27 citations

A Collagenolytic Response to Parathormone, 1,25-Dihydroxycholecalciferol D₃, and Prostaglandin E₂in Bone of Osteopetrotic (mi/mi) Mice*

1983 • 24 citations

Cellular Specificity of the Cure for Neonatal Osteopetrosis in the <i>ia </i>Rat

1983 • 23 citations

Isolation of a bone-resorptive factor from human cancer ascites fluid.

1978 • 22 citations

Skeletal changes during prolonged external irradiation: alterations in marrow, growth plate and osteoclast populations.

1979 • 20 citations

Longevity of osteoclasts in radiation chimaeras of osteopetrotic beige and normal mice.

1982 • 17 citations

The mode of growth of experimental metastases in rabbit femora

1974 • 17 citations

The Growth of Brown-Pearce Carcinoma in the Medullary Cavity of the Rabbit Femur

1963 • 16 citations

The Vitamin D Family Revisited

1984 • 15 citations

Cartilage and Bone Tissue Damage¹In Arthritis: Cellular Co-Operation and Enzymatic Mechanisms

1981 • 15 citations

Stable acid phosphatase: II. Effects of pH and inhibitors

1980 • 14 citations

Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity.

1983 • 13 citations

Newer Knowledge of Vitamin D and Its Metabolites in Health and Disease

1979 • 7 citations

Prostaglandins, Bone Resorption and Hyperglycemia (Cont.)

1974 • 2 citations

Cartilage and Bone Tissue-damage in Arthritis - Cellular Cooperation and Enzymatic Mechanisms

1981 • 2 citations