Bone-Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Bone: Formation by Autoinduction

1965 • 5,498 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Recombinant human bone morphogenetic protein induces bone formation.

1990 • 1,538 citations

Isolation of the bovine and human genes for müllerian inhibiting substance and expression of the human gene in animal cells

1986 • 997 citations

Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats

1972 • 815 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

1987 • 747 citations

Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-β

1985 • 722 citations

Purification and characterization of other distinct bone-inducing factors.

1988 • 621 citations

Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation.

1981 • 585 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

High efficiency gene transfer into mammalian cells

1984 • 498 citations

Purification and Partial Amino Acid Sequence of Osteogenin, a Protein Initiating Bone Differentiation

1989 • 405 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Isolation of osteogenin, an extracellular matrix-associated, bone-inductive protein, by heparin affinity chromatography.

1987 • 334 citations

Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin.

1989 • 224 citations

Matrix-Induced Endochondral Bone Differentiation: Influence of Hypophysectomy, Growth Hormone, and Thyroid-Stimulating Hormone

1980 • 138 citations

Transient production of proteins using an adenovirus transformed cell line

1990 • 129 citations

Recombinant TGF-β1 is Synthesized as a Two-Component Latent Complex that Shares Some Structural Features with the Native Platelet Latent TGF-β1 Complex

1989 • 108 citations

Osteogenin inhibits proliferation and stimulates differentiation in mouse osteoblast-like cells (MC3T3-E1)

1990 • 80 citations

Recombinant Expression and Characterization of Human Activin A

1988 • 79 citations

Dose-dependence of and Threshold for Optimal Bone Induction by Collagenous Bone Matrix and Osteogenin-enriched Fraction

1988 • 69 citations