Growth Hormone (GH) Receptors in Clonal Osteoblast Like Cells Mediate a Mitogenic Response to GH*

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

Analysis of radioligand binding experiments

1985 • 1,247 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Enzymatic iodination of polypeptides with 125I to high specific activity

1971 • 1,170 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*

1987 • 580 citations

Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I

1988 • 253 citations

Fracture Healing Perspectives

1985 • 203 citations

Characterization of an osteoblast-like clonal cell line which responds to both parathyroid hormone and calcitonin

1985 • 188 citations

17 beta-estradiol acts directly on the clonal osteoblastic cell line UMR106.

1987 • 180 citations

Growth hormone stimulates the proliferation of cultured chondrocytes from rabbit ear and rat rib growth cartilage

1983 • 150 citations

The somatotrophic axis in young steers: influence of nutritional status and oestradiol-17β on hepatic high-and low-affinity somatotrophic binding sites

1988 • 148 citations

Evidence from the use of monoclonal antibody probes for structural heterogeneity of the growth hormone receptor

1985 • 148 citations

Characterization of Somatogenic and Lactogenic Binding Sites in Isolated Rat Hepatocytes

1976 • 132 citations

Enhancement of erythropoiesis in vitro by human growth hormone is mediated by insulin‐like growth factor I

1988 • 130 citations

Induction of mRNA for IGF-I and -II during growth hormone-stimulated muscle hypertrophy

1988 • 103 citations

Regulation of alkaline phosphatase expression in a neonatal rat clonal calvarial cell strain by retinoic acid

1988 • 91 citations

Mitogenic effects of growth hormone in cultured human fibroblasts. Evidence for action via local insulin-like growth factor I production.

1988 • 87 citations

Epidermal growth factor receptors in clonal lines of a rat osteogenic sarcoma and in osteoblast-rich rat bone cells

1983 • 80 citations

Human Growth Hormone Enhances Chondrogenesis and Osteogenesis in a Tissue Culture System of Chondroprogenitor Cells*

1989 • 80 citations

GROWTH HORMONE IS MITOGENIC FOR FETAL MOUSE OSTEOBLASTS BUT NOT FOR UNDIFFERENTIATED BONE CELLS

1988 • 75 citations

Detection of two growth hormone receptor mRNAs and primary translation products in the mouse.

1988 • 65 citations

Measurement of Growth Hormone and Prolactin Receptor Turnover in Rat Liver*

1985 • 53 citations

Turnover of Growth Hormone Receptors in Rat Adipocytes*

1985 • 52 citations

A biomechanical study of the effects of growth hormone in experimental fracture healing

1980 • 51 citations

Growth hormone-binding proteins in high-speed cytosols of multiple tissues of the rabbit

1986 • 46 citations

Direct stimulatory effect of growth hormone on DNA synthesis of fetal chicken osteoblasts in culture

1988 • 42 citations

Regeneration of the calvarium in young normal and growth hormone‐treated hypophysectomized rats

1953 • 40 citations

SOLUBILIZATION OF A GROWTH HORMONE-SPECIFIC RECEPTOR FROM RABBIT LIVER

1977 • 32 citations

Rapid down regulation of insulin receptors in adipocytes artifact of the incubation buffer

1981 • 29 citations

Separate intracellular pathways for insulin receptor recycling and insulin degradation in isolated rat adipocytes

1983 • 27 citations

Human growth hormone in delayed union and non-union of fractures

1978 • 21 citations

Soluble forms of the rabbit adipose tissue and liver growth hormone receptors are antigenically identical, but the integral membrane forms differ

1990 • 15 citations

Specific binding of human and bovine growth hormones to hypophysectomized rat hepatocytes.

1976 • 11 citations

Hormonal Effects on the Morphology of Bone Defect Healing

1976 • 11 citations

An electrostatic model for the interaction between growth hormone and its receptor involving chelation of Ca2+ to the human growth hormone molecule

1989 • 9 citations

The proliferative capacity and DNA synthesis of osteoblasts during fracture repair in normal and hypophysectomized rats

1968 • 9 citations