Lipoproteins and Cellular Cholesterol Homeostasis

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Cholesterol and the cell membrane

1985 • 1,465 citations

Molecular physiology of reverse cholesterol transport.

1995 • 1,452 citations

High density lipoprotein metabolism.

1984 • 1,230 citations

Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

1990 • 1,039 citations

Role of Steroidogenic Acute Regulatory Protein in Adrenal and Gonadal Steroidogenesis

1995 • 1,019 citations

Plasma cholesteryl ester transfer protein

1993 • 948 citations

The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

1992 • 852 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

1980 • 727 citations

Early incorporation of cell-derived cholesterol into pre-.beta.-migrating high-density lipoprotein

1988 • 643 citations

Mechanisms and consequences of cellular cholesterol exchange and transfer

1987 • 547 citations

Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

1985 • 519 citations

Characterization of lipoprotein particles isolated by immunoaffinity chromatography. Particles containing A-I and A-II and particles containing A-I but no A-II.

1984 • 470 citations

Lecithin cholesterol acyltransferase

2000 • 460 citations

Cholesterol transport between cells and high-density lipoproteins

1991 • 451 citations

Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13.

1995 • 376 citations

Cholesterol efflux from cultured adipose cells is mediated by LpAI particles but not by LpAI:AII particles

1987 • 335 citations

Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.

1991 • 331 citations

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

1988 • 323 citations

Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages.

1994 • 315 citations

The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one

1989 • 315 citations

Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine.

1985 • 314 citations

Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane.

1990 • 304 citations

Regulation of high density lipoprotein receptor activity in cultured human skin fibroblasts and human arterial smooth muscle cells.

1983 • 276 citations

Protein composition determines the anti-atherogenic properties of HDL in transgenic mice

1993 • 276 citations

LDL receptor‐related protein: a multiligand receptor for lipoprotein and proteinase catabolism

1995 • 272 citations

Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses.

1991 • 272 citations

Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux.

1992 • 269 citations

Transport of cholesterol from the endoplasmic reticulum to the plasma membrane.

1985 • 263 citations

Membrane Cholesterol Dynamics: Cholesterol Domains and Kinetic Pools

1991 • 262 citations

Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol

1991 • 259 citations

Cell Toxicity Induced by Inhibition of Acyl Coenzyme A:Cholesterol Acyltransferase and Accumulation of Unesterified Cholesterol

1995 • 258 citations

The role of apolipoprotein A-IV in reverse cholesterol transport studied with cultured cells and liposomes derived from an ether analog of phosphatidylcholine

1986 • 238 citations

Intracellular Cholesterol Transport and Compartmentation

1995 • 226 citations

Factors influencing the lipid composition and fluidity of red cell membranes in vitro: production of red cells possessing more than two cholesterols per phospholipid

1978 • 219 citations

A cell culture system for screening human serum for ability to promote cellular cholesterol efflux. Relations between serum components and efflux, esterification, and transfer.

1994 • 203 citations

The effects of subfractions of high density lipoprotein on cholesterol efflux from cultured fibroblasts. Regulation of low density lipoprotein receptor activity.

1981 • 201 citations

Intracellular cholesterol transport.

1992 • 196 citations

Binding of high density lipoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface.

1987 • 193 citations

Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides

1995 • 188 citations

The bidirectional flux of cholesterol between cells and lipoproteins. Effects of phospholipid depletion of high density lipoprotein.

1986 • 186 citations

A plasma lipoprotein containing only apolipoprotein Eand with gamma mobility on electrophoresis releases cholesterol fromcells.

1994 • 177 citations

Bile acid synthesis from cholesterol: regulatory and auxiliary pathways

1994 • 175 citations

Progesterone blocks cholesterol translocation from lysosomes.

1992 • 170 citations

Sterol Carrier Protein-2 Is Involved in Cholesterol Transfer from the Endoplasmic Reticulum to the Plasma Membrane in Human Fibroblasts

1995 • 167 citations

Advances in Cholesterol Research

1990 • 160 citations

Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells.

1992 • 157 citations

Physiological role and clinical relevance of high-density lipoprotein subclasses

1994 • 153 citations

High density lipoprotein apolipoproteins mediate removal of sterol from intracellular pools but not from plasma membranes of cholesterol-loaded fibroblasts.

1991 • 150 citations

Cholesterol net transport, esterification, and transfer in human hyperlipidemic plasma.

1983 • 149 citations

Lysosomes

1989 • 147 citations

The Effect of High Density Lipoprotein Phospholipid Acyl Chain Composition on the Efflux of Cellular Free Cholesterol

1995 • 146 citations

Structural models of human apolipoprotein A-I

1995 • 145 citations

A macrophage receptor for oxidized low density lipoprotein distinct from the receptor for acetyl low density lipoprotein: partial purification and role in recognition of oxidatively damaged cells.

1995 • 144 citations

Cholesterol domains in biological membranes

1995 • 143 citations

Packing of cholesterol molecules in human low-density lipoprotein

1986 • 141 citations

Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level.

1991 • 137 citations

Formation of cholesterol monohydrate crystals in macrophage-derived foam cells.

1994 • 136 citations

Differential accumulation of cholesterol in Golgi compartments of normal and Niemann-Pick type C fibroblasts incubated with LDL: a cytochemical freeze-fracture study

1993 • 135 citations

Acyl coenzyme A:cholesterol acyl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate.

1988 • 134 citations

Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha electrophoretic mobilities.

1992 • 130 citations

Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol.

1992 • 129 citations

Effects of Acceptor Particle Size on the Efflux of Cellular Free Cholesterol

1995 • 128 citations

A comparative study on the removal of cellular lipids from Landschütz ascites cells by human plasma apolipoproteins.

1975 • 127 citations

Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm.

1990 • 124 citations

Sorting of an internalized plasma membrane lipid between recycling and degradative pathways in normal and Niemann-Pick, type A fibroblasts.

1990 • 123 citations

Apolipoprotein A-containing lipoprotein particles: physiological role, quantification, and clinical significance.

1992 • 122 citations

Transfer of cholesterol from its site of synthesis to the plasma membrane.

1984 • 122 citations

An interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A-I genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels.

1992 • 122 citations

A functional role for vimentin intermediate filaments in the metabolism of lipoprotein-derived cholesterol in human SW-13 cells.

1992 • 121 citations

Cholesterol homeostasis. Modulation by amphiphiles.

1994 • 120 citations

Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT

1995 • 120 citations

Cholesterol synthesis in rat liver peroxisomes. Conversion of mevalonic acid to cholesterol.

1987 • 117 citations

In vitro and in vivo evidence for the role of HDL in reverse cholesterol transport

1994 • 113 citations

Regulation of the concentration of pre.beta. high-density lipoprotein in normal plasma by cell membranes and lecithin-cholesterol acyltransferase activity

1992 • 110 citations

Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking.

1990 • 109 citations

Rapid intracellular transport of LDL-derived cholesterol to the plasma membrane in cultured fibroblasts.

1990 • 108 citations

Quantitation of pre.beta.-HDL-dependent and nonspecific components of the total efflux of cellular cholesterol and phospholipid

1993 • 107 citations

Reverse cholesterol transport

1986 • 107 citations

High density lipoprotein stimulates sterol translocation between intracellular and plasma membrane pools in human monocyte-derived macrophages.

1989 • 103 citations

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages.

1993 • 102 citations

Role of the plasma membrane in cholesterol esterification in rat hepatoma cells

1993 • 102 citations

Distribution of Cholesterol Precursors and Other Lipids among Rat Liver Intracellular Structures

1968 • 101 citations

Spontaneous lipid transfer between organized lipid assemblies

1992 • 100 citations

Cholesterol efflux from cells to immunopurified subfractions of human high density lipoprotein: LP-AI and LP-AI/AII.

1991 • 99 citations

Apolipoprotein A-Containing Lipoprotein Particles: Physiological Role, Quantification, and Clinical Significance

1992 • 99 citations

Heparin-releasable (liver) lipase(s) may play a role in the uptake of cholesterol by steroid-secreting tissues

1980 • 98 citations

Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol.

1992 • 97 citations

Apolipoprotein A-I–Mediated Efflux of Sterols From Oxidized LDL–Loaded Macrophages

1995 • 96 citations

Development of the smooth muscle foam cell: uptake of macrophage lipid inclusions.

1986 • 95 citations

Effects of high density lipoprotein subfractions on cholesterol homeostasis in human fibroblasts and arterial smooth muscle cells.

1983 • 94 citations

Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease

1990 • 93 citations

Biology of Cholesterol

1988 • 92 citations

Human noninsulin-dependent diabetes: identification of a defect in plasma cholesterol transport normalized in vivo by insulin and in vitro by selective immunoadsorption of apolipoprotein E.

1982 • 91 citations

cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J7774 macrophages.

1991 • 90 citations

The influence of cellular and lipoprotein cholesterol contents on the flux of cholesterol between fibroblasts and high density lipoprotein.

1988 • 90 citations

The efflux of lysosomal cholesterol from cells.

1990 • 89 citations

Cholesterol-rich intracellular membranes: a precursor to the plasma membrane.

1985 • 88 citations

Reverse Cholesterol Transport in Plasma of Patients With Different Forms of Familial HDL Deficiency

1995 • 85 citations

Movement of zymosterol, a precursor of cholesterol, among three membranes in human fibroblasts.

1991 • 83 citations

Differential role of apolipoprotein AI-containing particles in cholesterol efflux from adipose cells

1991 • 79 citations

Cholesterol movement from plasma membrane to rough endoplasmic reticulum. Inhibition by progesterone.

1994 • 78 citations

Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells.

1990 • 76 citations

The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein.

1994 • 75 citations

Purification and characterization of two high-density-lipoprotein-binding proteins from rat and human liver

1989 • 74 citations

Monensin and Brefeldin A Inhibit High Density Lipoprotein- mediated Cholesterol Efflux from Cholesterol-enriched Cells

1995 • 74 citations

Expression of hormone-sensitive lipase mRNA in macrophages.

1993 • 73 citations

High-density lipoprotein subclasses

1994 • 72 citations

Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblasts. Evidence that 27-hydroxycholesterol can be an important intracellular mediator between LDL and the suppression of cholesterol production

1995 • 71 citations

Lipid composition and physical state effects on cellular cholesteryl ester clearance.

1984 • 71 citations

The role of apolipoprotein A-l-containing lipoproteins in atherosclerosis

1994 • 67 citations

Differential effect of subspecies of lipoprotein containing apolipoprotein A-I on cholesterol efflux from cholesterol-loaded macrophages: Functional correlation with lecithin : cholesterol acyltransferase

1992 • 67 citations

Role of apolipoproteins in cellular cholesterol efflux

1986 • 67 citations

Cyclic AMP mediated modification of cholesterol traffic in Leydig tumor cells.

1987 • 66 citations

Stability of free apolipoprotein A-1 concentration in serum, and its measurement in normal and hyperlipidemic subjects.

1987 • 60 citations

Effects of high-density lipoprotein particles containing apo A-I, with or without apo A-II, on intracellular cholesterol efflux

1993 • 59 citations

Acid hydrolases in early and late endosome fractions from rat liver.

1991 • 58 citations

Localization of an apolipoprotein A-I epitope critical for lipoprotein-mediated cholesterol efflux from monocytic cells.

1994 • 58 citations

Modulation of Cholesterol Efflux from Fu5AH Hepatoma Cells by the Apolipoprotein Content of High Density Lipoprotein Particles.

1995 • 56 citations

Species difference in cholesteryl ester cycle and HDL-induced cholesterol efflux from macrophage foam cells.

1994 • 56 citations

Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells.

1993 • 52 citations

Cholesterol is poorly available for free apolipoprotein-mediated cellular lipid efflux from smooth muscle cells

1993 • 52 citations

Effects of membrane lipid composition on the kinetics of cholesterol exchange between lipoproteins and different species of red blood cells

1990 • 51 citations

Evidence for the separation of albumin- and apo A-I-dependent mechanisms of cholesterol efflux from cultured fibroblasts into human plasma.

1982 • 51 citations

Cholesterol transport from plasma membranes to intracellular membranes is inhibited by 3β-[2-(diethylamino) ethoxy]androst-5-en-17-one

1994 • 50 citations

Cholesterol: Its Functions and Metabolism in Biology and Medicine

1997 • 49 citations

Trafficking of lipids from the endoplasmic reticulum to the Golgi apparatus in a cell-free system from rat liver

1991 • 49 citations

Apolipoprotein A-I metabolism in cholesteryl ester transfer protein transgenic mice. Insights into the mechanisms responsible for low plasma high density lipoprotein levels.

1994 • 48 citations

Role of the plasma membrane in the mechanism of cholesterol efflux from cells

1984 • 47 citations

Influence of lecithin:cholesterol acyltransferase on cholesterol metabolism in hepatoma cells and hepatocytes

1980 • 46 citations

Influence of apolipoproteins AI, AII, and Cs on the metabolism of membrane and lysosomal cholesterol in macrophages.

1991 • 45 citations

Zymosterol is located in the plasma membrane of cultured human fibroblasts.

1990 • 45 citations

Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.

1995 • 44 citations

Packing of cholesterol molecules in human high-density lipoproteins

1984 • 44 citations

Partially reassembled high density lipoproteins. Effects on cholesterol flux, synthesis, and esterification in normal human skin fibroblasts.

1986 • 43 citations

Structural domain of apolipoprotein A-I involved in its interaction with cells

1994 • 41 citations

Cholesterol efflux is defective in macrophages from atherosclerosis-susceptible White Carneau pigeons relative to resistant show racer pigeons.

1992 • 41 citations

Resistance of smooth muscle cells to assembly of high density lipoproteins with extracellular free apolipoproteins and to reduction of intracellularly accumulated cholesterol.

1992 • 40 citations

Mechanism of the defect in cholesteryl ester clearance from macrophages of atherosclerosis-susceptible White Carneau pigeons.

1994 • 38 citations

Efflux of Newly Synthesized Cholesterol and Biosynthetic Sterol Intermediates from Cells

1995 • 37 citations

The properties of HDL in genetically engineered mice

1994 • 36 citations

Structure-specific inhibition of lysosomal cholesterol transport in macrophages by various steroids

1994 • 34 citations

Cholesterol efflux from macrophages mediated by high-density lipoprotein subfractions, which differ principally in apolipoprotein A-I and apolipoprotein A-II ratios

1991 • 33 citations

Cholesteryl ester cycle in cultured hepatoma cells

1987 • 33 citations

Extravascular circulation of lipoproteins: their role in reverse transport of cholesterol

1994 • 29 citations

A second complementation class of cholesterol transport mutants with a variant Niemann-Pick type C phenotype

1994 • 29 citations

Gradient gel electrophoresis-immunoblot analysis (GGEI): a sensitive method for apolipoprotein profile determinations.

1987 • 28 citations

Mobilization of cholesterol from cholesterol ester-enriched tissue culture cells by phospholipid dispersions

1982 • 27 citations

Lack of requirement for sterol carrier protein-2 in the intracellular trafficking of lysosomal cholesterol.

1994 • 27 citations

Topographic heterogeneity in cholesterol biosynthesis.

1988 • 26 citations

Characterization of Chinese hamster ovary cells that are resistant to 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one inhibition of low density lipoprotein-derived cholesterol metabolism.

1991 • 25 citations

Side-chain structure is critical for the transport of sterols from lysosomes to cytoplasm

1995 • 24 citations

Increased cholesterol synthesis in Chinese hamster ovary cells deficient in peroxisomes

1992 • 24 citations

Efflux of phospholipid from fibroblasts with normal and elevated levels of cholesterol

1991 • 24 citations

Cholesterol trafficking in cells

1990 • 22 citations

Cholesterol efflux from arterial wall cells

1991 • 21 citations

NADH-activated cell-free transfer between Golgi apparatus and plasma membranes of rat liver

1992 • 19 citations

The relationship between HDL-, LDL-, liposomes-free cholesterol, biliary cholesterol and bile salts in the rat

1987 • 18 citations

Type C Niemann-Pick disease: dimethyl sulfoxide moderates abnormal LDL-cholesterol processing in mutant fibroblasts

1989 • 18 citations

Effects of interactions of apolipoprotein A-II with apolipoproteins A-I or A-IV on [3H]cholesterol efflux and uptake in cell culture

1995 • 17 citations

Chapter 10 Lecithin cholesterol acyltransferase

1987 • 16 citations

Localization and Movement of Newly Synthesized Cholesterol in Rat Ovarian Granulosa Cells*

1988 • 13 citations

Mycoplasma Membrane Lipids Chemical Composition and Transbilayer Distribution

1993 • 12 citations

Effects of membrane lipids and -proteins and cytoskeletal proteins on the kinetics of cholesterol exchange between high density lipoprotein and human red blood cells, ghosts and microvesicles

1992 • 8 citations

Active cholesterol biosynthesis in cultured aortic smooth muscle cells: evolution during the life-span of the culture

1991 • 7 citations

Cell-free transfer of sterols from dictyosome-like structures to plasma membrane vesicles of guinea pig testes

1990 • 4 citations

Cell-free transfer of cholesterol from lysosomes to phospholipid vesicles.

1996 • 4 citations

Deleted Work

1955 • 0 citations