In vitro and in vivo evidence for the role of HDL in reverse cholesterol transport

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE

1975 • 2,653 citations

The plasma lecithin:cholesterol acyltransferase reaction

1968 • 2,415 citations

A Prospective Study of Cholesterol, Apolipoproteins, and the Risk of Myocardial Infarction

1991 • 1,184 citations

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

1991 • 990 citations

Increased High-Density Lipoprotein Levels Caused by a Common Cholesteryl-Ester Transfer Protein Gene Mutation

1990 • 848 citations

Ten-Year Mortality from Cardiovascular Disease in Relation to Cholesterol Level among Men with and without Preexisting Cardiovascular Disease

1990 • 834 citations

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

1990 • 767 citations

Early incorporation of cell-derived cholesterol into pre-.beta.-migrating high-density lipoprotein

1988 • 643 citations

Mechanisms and consequences of cellular cholesterol exchange and transfer

1987 • 547 citations

Characterization of lipoprotein particles isolated by immunoaffinity chromatography. Particles containing A-I and A-II and particles containing A-I but no A-II.

1984 • 470 citations

Cholesterol transport between cells and high-density lipoproteins

1991 • 451 citations

Uptake of high-density lipoprotein-associated apoprotein A-I and cholesterol esters by 16 tissues of the rat in vivo and by adrenal cells and hepatocytes in vitro.

1985 • 380 citations

Enhanced macrophage uptake of low density lipoprotein after self-aggregation.

1988 • 371 citations

Cholesterol efflux from cultured adipose cells is mediated by LpAI particles but not by LpAI:AII particles

1987 • 335 citations

Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.

1991 • 331 citations

Apolipoprotein A-I containing lipoproteins in coronary artery disease

1987 • 330 citations

A nonendocytotic mechanism for the selective uptake of high density lipoprotein-associated cholesterol esters.

1987 • 319 citations

[32] Reconstitution of high-density lipoproteins

1986 • 316 citations

Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts.

1979 • 303 citations

Preferential Utilization of Free Cholesterol From High-Density Lipoproteins for Biliary Cholesterol Secretion in Man

1978 • 300 citations

Distribution and Functions of Lecithin: Cholesterol Acyltransferase and Cholesteryl Ester Transfer Protein in Plasma Lipoproteins

1989 • 282 citations

Regulation of high density lipoprotein receptor activity in cultured human skin fibroblasts and human arterial smooth muscle cells.

1983 • 276 citations

Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol

1991 • 259 citations

Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages.

1985 • 245 citations

Pathophysiology of reverse cholesterol transport. Insights from inherited disorders of lipoprotein metabolism.

1989 • 241 citations

High Levels of Human Apolipoprotein A-I in Transgenic Mice Result in Increased Plasma Levels of Small High Density Lipoprotein (HDL) Particles Comparable to Human HDL3

1989 • 238 citations

Plasma apolipoprotein A-1 absence associated with a marked reduction of high density lipoproteins and premature coronary artery disease.

1982 • 235 citations

Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting.

1987 • 215 citations

High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits.

1989 • 211 citations

Enterohepatic circulation in the rat

1985 • 207 citations

Direct evidence that reverse cholesterol transport is mediated by high-density lipoprotein in rabbit

1985 • 207 citations

Binding of high density lipoproteins to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface.

1987 • 193 citations

Subpopulations of apolipoprotein A-I in human high-density lipoproteins their metabolic properties and response to drug therapy

1983 • 185 citations

In vivo metabolism of apolipoprotein A-I on high density lipoprotein particles LpA-I and LpA-I,A-II.

1991 • 178 citations

Clinical, biochemical, and genetic features in familial disorders of high density lipoprotein deficiency.

1984 • 177 citations

Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells.

1992 • 157 citations

Interaction of high density lipoprotein with its receptor on cultured fibroblasts and macrophages. Evidence for reversible binding at the cell surface without internalization.

1987 • 141 citations

Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women.

1989 • 140 citations

Prebeta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer.

1987 • 139 citations

Regulation of high density lipoprotein receptors in cultured macrophages: role of acyl-CoA:cholesterol acyltransferase.

1985 • 137 citations

Identification of apolipoproteins involved in the interaction of human high density lipoprotein3 with receptors on cultured cells.

1985 • 130 citations

Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha electrophoretic mobilities.

1992 • 130 citations

Protective effect of lipoproteins containing apoprotein A‐I on Cu²⁺ ‐ catalyzed oxidation of human low density lipoprotein

1989 • 126 citations

Cholesterol flux between cells and high density lipoprotein. Lack of relationship to specific binding of the lipoprotein to the cell surface.

1987 • 124 citations

Mechanism of cholesterol efflux from cells

1980 • 122 citations

A hepatocyte receptor for high-density lipoproteins specific for apolipoprotein A-I.

1984 • 119 citations

Cell-derived unesterified cholesterol cycles between different HDLs and LDL for its effective esterification in plasma.

1993 • 116 citations

Evaluation of pathways for the cellular uptake of high density lipoprotein cholesterol esters in rabbits.

1991 • 109 citations

In vitro exchanges of esterified cholesterol between serum lipoprotein fractions: Studies of humans and rabbits

1979 • 107 citations

Characterization of a human hepatic receptor for high density lipoproteins.

1985 • 104 citations

Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-I.

1990 • 101 citations

High-affinity uptake and degradation of ApoE-free high-density lipoprotein and low-density lipoprotein in cultured porcine hepatocytes

1982 • 101 citations

Cholesterol efflux from cells to immunopurified subfractions of human high density lipoprotein: LP-AI and LP-AI/AII.

1991 • 99 citations

Characterization of dog peripheral lymph lipoproteins: the presence of a disc-shaped "nascent" high density lipoprotein.

1983 • 99 citations

Role of apolipoproteins in cholesterol efflux from macrophages to lipid microemulsion: proposal of a putative model for the pre-.beta.-high-density lipoprotein pathway

1992 • 98 citations

Regulation of the selective uptake of high density lipoprotein-associated cholesteryl esters

1987 • 98 citations

Effects of high density lipoprotein subfractions on cholesterol homeostasis in human fibroblasts and arterial smooth muscle cells.

1983 • 94 citations

Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs.

1992 • 92 citations

The influence of cellular and lipoprotein cholesterol contents on the flux of cholesterol between fibroblasts and high density lipoprotein.

1988 • 90 citations

Differential role of apolipoprotein AI-containing particles in cholesterol efflux from adipose cells

1991 • 79 citations

Metabolism of apoE-free high density lipoproteins in rat hepatoma cells: evidence for a retroendocytic pathway.

1990 • 78 citations

Purification and characterization of two high-density-lipoprotein-binding proteins from rat and human liver

1989 • 74 citations

An investigation of the role of lecithin: cholesterol acyltransferase and triglyceride-rich lipoproteins in the metabolism of pre-beta high density lipoproteins

1991 • 72 citations

Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation

1990 • 72 citations

Selective uptake of cholesteryl esters from apolipoprotein-E-free high-density lipoproteins by rat parenchymal cells in vivo is efficiently coupled to bile acid synthesis

1991 • 72 citations

A one-step separation of human serum high density lipoproteins 2 and 3 by rate-zonal density gradient ultracentrifugation in a swinging bucket rotor

1982 • 70 citations

Role of apolipoproteins in cellular cholesterol efflux

1986 • 67 citations

Differential effect of subspecies of lipoprotein containing apolipoprotein A-I on cholesterol efflux from cholesterol-loaded macrophages: Functional correlation with lecithin : cholesterol acyltransferase

1992 • 67 citations

A study of the small spherical high density lipoproteins of patients afflicted with familial lecithin: cholesterol acyltransferase deficiency.

1984 • 66 citations

Interconversion of prebeta-migrating lipoproteins containing apolipoprotein A-I and HDL.

1990 • 64 citations

Uptake and degradation of 125I-labelled high density lipoproteins in rat liver cells in vivo and in vitro

1979 • 62 citations

Lipoproteins of human peripheral lymph

1990 • 60 citations

Effects of high-density lipoprotein particles containing apo A-I, with or without apo A-II, on intracellular cholesterol efflux

1993 • 59 citations

Structure of the dimyristoylphosphatidylcholine vesicle and the complex formed by its interaction with apolipoprotein C-III: x-ray small angle scattering studies

1979 • 57 citations

Characterization of dog prenodal peripheral lymph lipoproteins. Evidence for the peripheral formation of lipoprotein-unassociated apoA-I with slow pre-beta electrophoretic mobility.

1988 • 55 citations

Partial purification of a high density lipoprotein‐binding protein from rat liver and kidney membranes

1986 • 55 citations

Binding of apolipoprotein A-I and apolipoprotein A-IV to cultured bovine aortic endothelial cells.

1988 • 55 citations

Retroendocytosis of high density lipoproteins by the human hepatoma cell line, HepG2.

1990 • 55 citations

Relationship in adipose cells between the presence of receptor sites for high density lipoproteins and the promotion of reverse cholesterol transport

1987 • 54 citations

Binding of apolipoprotein A-I and A-II after recombination with phospholipid vesicles to the high density lipoprotein receptor of luteinized rat ovary.

1985 • 54 citations

The role of apolipoproteins of HDL in the selective uptake of cholesteryl linoleyl ether by cultured rat and bovine adrenal cells

1986 • 51 citations

The binding of high density lipoproteins to isolated rat hepatocytes

1981 • 51 citations

Radiation inactivation of binding sites for high density lipoproteins in human fibroblast membranes.

1988 • 49 citations

Up-regulation of high density lipoprotein receptor activity by gamma-interferon associated with inhibition of cell proliferation.

1988 • 46 citations

Endocytic pathway of high density lipoprotein via trans-Golgi system in rat resident peritoneal macrophages.

1989 • 45 citations

Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells.

1984 • 45 citations

Human lymphedema fluid lipoproteins: particle size, cholesterol and apolipoprotein distributions, and electron microscopic structure.

1985 • 45 citations

Effect of lipid transfer protein on plasma lipids, apolipoproteins and metabolism of high-density lipoprotein cholesteryl ester in the rat

1989 • 45 citations

Evidence for reverse cholesterol transport in vivo from liver endothelial cells to parenchymal cells and bile by high-density lipoprotein

1990 • 39 citations

Evidence for two sites on rat liver plasma membranes which interact with high density lipoprotein.

1992 • 38 citations

Cell-surface binding sites for high density lipoproteins do not mediate efflux of cholesterol from human fibroblasts in tissue culture.

1988 • 36 citations

A pool of reversibly cell-associated cholesteryl esters involved in the selective uptake of cholesteryl esters from high-density lipoproteins by Hep G2 hepatoma cells

1993 • 35 citations

Discrimination between subclasses of human high-density lipoproteins by the HDL binding sites of bovine liver

1986 • 35 citations

Characterization of human high-density lipoprotein subclasses LP A-I and LP A-I/A-II and binding to HepG2 cells

1990 • 33 citations

High-density lipoprotein particle uptake and selective uptake of high-density lipoprotein-associated cholesteryl esters by J774 macrophages

1990 • 31 citations

Antibodies to the carboxyl terminus of human apolipoprotein A-I. The putative cellular binding domain of high density lipoprotein 3 and carboxyl-terminal structural homology between apolipoproteins A-I and A-II.

1992 • 31 citations

Characterization in vitro of interaction of human apolipoprotein E-free high density lipoprotein with human hepatocytes.

1990 • 30 citations

Interaction in vivo and in vitro of apolipoprotein E-free high-density lipoprotein with parenchymal, endothelial and Kupffer cells from rat liver

1988 • 26 citations

Selective association of lipoprotein cholesteryl esters with liver plasma membranes

1993 • 23 citations

Uptake and metabolism of high-density lipoproteins by cultured rabbit hepatocytes

1990 • 23 citations

Demonstration of a high density lipoprotein (HDL)‐binding protein in Hep G2 cells using colloidal gold‐HDL conjugates

1988 • 21 citations

Reverse cholesterol transport in the isolated perfused rat spleen

1990 • 18 citations

Radiation inactivation of binding sites for high-density lipoproteins in human liver membranes

1988 • 18 citations

Reverse cholesterol transport in the rat. Studies using the isolated perfused spleen in conjunction with the perfused liver

1991 • 18 citations

Binding characteristics of high density lipoprotein subclasses to porcine liver, adrenal and skeletal muscle plasma membranes

1989 • 17 citations

Regulation of hepatic high density lipoprotein binding proteins after administration of simvastatin and cholestyramine to rats.

1990 • 17 citations

Binding, uptake, and degradation of 125I-labelled high-density lipoproteins in isolated non-parenchymal rat liver cells.

1981 • 17 citations

High density lipoprotein-binding proteins in porcine liver. Isolation and histological localization.

1992 • 15 citations

Effects of truncal vagotomy on tissue gastrin content and G cell density in rats

1981 • 9 citations

Increase in selective hepatic uptake of high-density lipoprotein cholesteryl esters in the fasted rabbit

1990 • 8 citations