Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Rapid separation of lipid classes in high yield and purity using bonded phase columns.

1985 • 939 citations

Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis.

1991 • 479 citations

Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase.

1984 • 312 citations

Cerebrotendinous xanthomatosis: a defect in mitochondrial 26-hydroxylation required for normal biosynthesis of cholic acid.

1980 • 221 citations

Mechanism of degradation of the steroid side chain in the formation of bile acids.

1992 • 213 citations

Frameshift and splice-junction mutations in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis in Jews or Moroccan origin.

1993 • 187 citations

Bile Acid Synthesis in Man: Metabolism of 7α-Hydroxycholesterol-14C and 26-Hydroxycholesterol-3H

1972 • 155 citations

Purification of Oxysterol Binding Protein from Hamster Liver Cytosol

1989 • 121 citations

Occurrence of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood.

1988 • 109 citations

Demonstration of 26-hydroxylation of C27-steroids in human skin fibroblasts, and a deficiency of this activity in cerebrotendinous xanthomatosis.

1986 • 106 citations

Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques

1966 • 99 citations

26-Hydroxycholesterol: synthesis, metabolism, and biologic activities

1990 • 82 citations

cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19

1990 • 81 citations

Formation of 7α- and 7β-hydroxylated bile acid precursors from 27-hydroxycholesterol in human liver microsomes and mitochondria

1993 • 73 citations

Simultaneous quantification of several cholesterol autoxidation and monohydroxylation products by isotope-dilution mass spectrometry

1990 • 70 citations

Role of the 26-hydroxylase in the biosynthesis of bile acids in the normal state and in cerebrotendinous xanthomatosis. An in vivo study.

1983 • 61 citations

Identification of new mutations in sterol 27-hydroxylase gene in Japanese patients with cerebrotendinous xanthomatosis (CTX).

1994 • 61 citations

Cerebrotendinous xanthomatosis: reduced serum 26-hydroxycholesterol.

1982 • 50 citations

Evidence that 24- and 27-hydroxylation are not involved in the cholesterol-induced down-regulation of hydroxymethylglutaryl-CoA reductase in mouse liver.

1992 • 47 citations

Selective inhibition of mitochondrial 27-hydroxylation of bile acid intermediates and 25-hydroxylation of vitamin D3 by cyclosporin A

1993 • 47 citations

7α-Hydroxylation of 27-hydroxycholesterol in human liver microsomes

1992 • 43 citations

Sterol 27-hydroxylase in bile acid biosynthesis. Mechanism of oxidation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,27-tetrol into 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid

1993 • 38 citations

Cholestanol and 26-hydroxycholesterol in normal and atherosclerotic human aorta

1971 • 35 citations

Characterization of a binding protein for the PCB metabolite 4,4?-bis(methylsulfonyl)-2,2?,5,5?-tetrachlorobiphenyl present in bronchoalveolar lavage from healthy smokers and non-smokers

1986 • 29 citations

Sterol metabolism

1973 • 25 citations

Reconstitution of C27-steroid 26-hydroxylase activity from bovine brain mitochondria.

1989 • 21 citations

Evidence for the formation of 26-hydroxycholesterol by cytochrome P-450 in pig kidney mitochondria

1989 • 17 citations