LDL receptor‐related protein: a multiligand receptor for lipoprotein and proteinase catabolism

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

1990 • 666 citations

Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein.

1991 • 627 citations

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

1989 • 600 citations

Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.

1994 • 550 citations

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

1992 • 548 citations

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

1990 • 451 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.

1992 • 341 citations

Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist

1994 • 311 citations

Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.

1990 • 279 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin.

1990 • 268 citations

Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.

1994 • 266 citations

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1992 • 244 citations

Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family.

1994 • 241 citations

The Urokinase Receptor. Protein Structure and Role in Plasminogen Activation and Cancer Invasion

1995 • 235 citations

Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen

1991 • 230 citations

Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.

1994 • 211 citations

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

1992 • 190 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase.

1993 • 186 citations

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor.

1994 • 177 citations

Strategies for the Improvement of Thrombolytic Agents

1991 • 170 citations

alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation.

1994 • 170 citations

Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions.

1994 • 140 citations

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.

1994 • 135 citations

Binding and degradation of platelet thrombospondin by cultured fibroblasts.

1984 • 126 citations

The 39-kDa Receptor-associated Protein Modulates Lipoprotein Catabolism by Binding to LDL Receptors

1995 • 121 citations

The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and mediates binding of normal very low density lipoproteins to LRP.

1994 • 115 citations

A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans.

1993 • 114 citations

Purification of the Rat Hepatic α2-Macroglobulin Receptor as an Approximately 440-kDa Single Chain Protein

1989 • 112 citations

The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor.

1994 • 110 citations

Heparin binding to the urokinase kringle domain

1992 • 106 citations

Oocytes from the Mutant Restricted Ovulator Hen Lack Receptor for Very Low Density Lipoprotein

1989 • 82 citations

Cellular receptors for the plasminogen activators

1994 • 80 citations

Effect of the 39-kDa receptor-associated protein on the hepatic uptake and endocytosis of chylomicron remnants and low density lipoproteins in the rat.

1994 • 77 citations

LDL receptor-related protein (LRP): a multiligand receptor

1994 • 62 citations

Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator.

1994 • 51 citations

Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response.

1993 • 50 citations

Structure of the low-density lipoprotein receptor-related protein (LRP) promoter

1989 • 47 citations

Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER

1993 • 46 citations

Invariant chain — a regulator of antigen presentation

1992 • 38 citations

Presence of LDL receptor-related protein/alpha 2-macroglobulin receptors in macrophages of atherosclerotic lesions from cholesterol-fed New Zealand and heterozygous Watanabe heritable hyperlipidemic rabbits.

1994 • 33 citations