Bile acid synthesis from cholesterol: regulatory and auxiliary pathways

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Biological Activity of Some Oxygenated Sterols

1978 • 570 citations

Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis.

1991 • 479 citations

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol

1984 • 393 citations

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.

1990 • 365 citations

Long-Term Treatment of Cerebrotendinous Xanthomatosis with Chenodeoxycholic Acid

1984 • 361 citations

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.

1993 • 293 citations

Effect of Biliary Drainage on Individual Reactions in the Conversion of Cholesterol to Taurocholic Acid

1967 • 261 citations

THE BIOLOGICAL CONVERSION OF CHOLESTEROL TO CHOLIC ACID

1943 • 229 citations

Bile Acid Synthesis in Man: Metabolism of 7α-Hydroxycholesterol-14C and 26-Hydroxycholesterol-3H

1972 • 155 citations

Effect of thyroid hormone on hepatic cholesterol 7α hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats

1990 • 151 citations

26-Hydroxycholesterol. Identification and quantitation in human serum.

1981 • 120 citations

Occurrence of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood.

1988 • 109 citations

Cloning of the human cholesterol 7α-hydroxylase gene (CYP7) and localization to chromosome 8q11–q12

1992 • 106 citations

Dietary cholesterol and downregulation of cholesterol 7 alpha-hydroxylase and cholesterol absorption in African green monkeys.

1994 • 104 citations

Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes.

1993 • 99 citations

Sterol 27-hydroxylase: high levels of activity in vascular endothelium.

1994 • 88 citations

Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression.

1994 • 82 citations

Mechanism of Formation of Bile Acids from Cholesterol: Oxidation of 5β-Cholestane-3α,7α,12α-triol and Formation of Propionic Acid from the Side Chain by Rat Liver Mitochondria

1962 • 82 citations

Bile acid and sterol solubilization in 2-hydroxypropyl-beta-cyclodextrin.

1992 • 79 citations

Cholesterol and bile acids regulate cholesterol 7 alpha-hydroxylase expression at the transcriptional level in culture and in transgenic mice.

1994 • 72 citations

Hepatic cholesterol metabolism in cholesterol gallstone disease

1991 • 70 citations

Regulation of cholesterol 7 alpha-hydroxylase gene expression in Hep-G2 cells. Effect of serum, bile salts, and coordinate and noncoordinate regulation with other sterol-responsive genes

1994 • 65 citations

26-hydroxycholesterol: regulation of hydroxymethylglutaryl-CoA reductase activity in Chinese hamster ovary cell culture.

1983 • 63 citations

Cholesterol is converted to 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in liver mitochondria. Evidence for a mitochondrial sterol 7 alpha-hydroxylase.

1992 • 57 citations

Genomic Cloning, Sequencing, and Analysis of the Hamster Cholesterol 7α-Hydroxylase Gene (CYP7)

1993 • 51 citations

Purification and characterization of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol 27-hydroxylase from female rat liver mitochondria.

1988 • 48 citations

Biosynthesis of bile acids in cerebrotendinous xanthomatosis. Relationship of bile acid pool sizes and synthesis rates to hydroxylations at C-12, C-25, and C-26.

1985 • 47 citations

Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects.

1993 • 46 citations

Cerebrotendinous xanthomatosis (CTX): A clinical survey of the patient population in the Netherlands

1987 • 41 citations

Bile acid synthesis in man. II. Determination of 7 α-hydroxycholesterol, (22R)-22-hydroxycholesterol, and 26-hydroxycholesterol in human meconium

1977 • 40 citations

Transcriptional regulation of the gene encoding cholesterol 7α-hydroxylase in the rat

1993 • 40 citations

Cytotoxicity of cholesterol oxides and their effects on cholesterol metabolism in cultured human aortic smooth muscle cells.

1987 • 36 citations

12 alpha-hydroxylase activity in human liver and its relation to cholesterol 7 alpha-hydroxylase activity.

1992 • 27 citations

Polymorphisms of human cholesterol 7α-hydroxylase

1992 • 21 citations

Biosynthesis of Bile Acids in Cerebrotendinous Xanthomatosis

1985 • 10 citations