Nucleic acid based techniques for the detection of rare cancer cells in clinical samples.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors

1994 • 1,047 citations

Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood

1998 • 968 citations

Molecular Assessment of Histopathological Staging in Squamous-Cell Carcinoma of the Head and Neck

1995 • 759 citations

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

1991 • 711 citations

Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors

1992 • 703 citations

Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction

1991 • 658 citations

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 • 656 citations

Microsatellite alterations in serum DNA of head and neck cancer patients

1996 • 653 citations

Micrometastases and Survival in Stage II Colorectal Cancer

1998 • 602 citations

Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment

1996 • 521 citations

Significance of CD44 gene products for cancer diagnosis and disease evaluation

1992 • 470 citations

The Presence of Typical and Atypical BCR-ABL Fusion Genes in Leukocytes of Normal Individuals: Biologic Significance and Implications for the Assessment of Minimal Residual Disease

1998 • 457 citations

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

1998 • 448 citations

Microsatellite alterations as clonal markers for the detection of human cancer.

1994 • 448 citations

Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.

1994 • 443 citations

Molecular Detection of Primary Bladder Cancer by Microsatellite Analysis

1996 • 396 citations

Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction.

1994 • 382 citations

Genetic instability of cancer cells is proportional to their degree of aneuploidy

1998 • 378 citations

Detection of cancer micrometastases in lymph nodes by reverse transcriptase-polymerase chain reaction.

1995 • 366 citations

Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients.

1998 • 363 citations

CD44 variant exon epitopes in primary breast cancer and length of survival

1995 • 363 citations

CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines.

1991 • 347 citations

Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay.

1995 • 338 citations

Molecular staging of prostate cancer with the use of an enhanced reverse transcriptase-PCR assay

1994 • 320 citations

The DCC Protein and Prognosis in Colorectal Cancer

1996 • 307 citations

Limitations of reverse-transcriptase polymerase chain reaction analyses for detection of micrometastatic epithelial cancer cells in bone marrow.

1997 • 290 citations

Self-organization, complexity and chaos: The new biology for medicine

1998 • 286 citations

Detection of bladder cancer recurrence by microsatellite analysis of urine

1997 • 285 citations

Detection of Submicroscopic Lymph Node Metastases with Polymerase Chain Reaction in Patients with Malignant Melanoma

1994 • 280 citations

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

1992 • 280 citations

Dissemination of tumor cells in patients undergoing surgery for colorectal cancer.

1998 • 274 citations

Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction.

1994 • 271 citations

Cancer Cells Exhibit a Mutator Phenotype

1997 • 243 citations

Molecular detection of genetic alterations in the serum of colorectal cancer patients.

1998 • 240 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

ras and human tumors.

1992 • 224 citations

Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR.

1997 • 224 citations

Detection of circulating tumor cells in patients with localized and metastatic prostatic carcinoma: clinical implications.

1995 • 220 citations

Molecular Assays for Chromosomal Translocations in the Diagnosis of Pediatric Soft Tissue Sarcomas

1995 • 215 citations

Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease

1996 • 201 citations

Low specificity of cytokeratin 19 reverse transcriptase-polymerase chain reaction analyses for detection of hematogenous lung cancer dissemination.

1995 • 197 citations

Detection of circulating neoplastic cells by reverse-transcriptase polymerase chain reaction in malignant melanoma: association with clinical stage and prognosis.

1996 • 196 citations

Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.

1995 • 188 citations

Detection of breast cancer micrometastases in axillary lymph nodes by means of reverse transcriptase-polymerase chain reaction. Comparison between MUC1 mRNA and keratin 19 mRNA amplification.

1996 • 187 citations

Rapid and sensitive nonradioactive detection of mutant K-ras genes via 'enriched' PCR amplification.

1991 • 184 citations

Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcription-polymerase chain reaction in patients with gastrointestinal or breast carcinomas.

1998 • 183 citations

The Emerging Molecular Genetics of Sarcoma Translocations

1995 • 181 citations

Utilization of polymerase chain reaction technology in the detection of solid tumors

1998 • 181 citations

Detection of circulating tumor cells in men with localized prostate cancer.

1994 • 180 citations

Identification of a novel cytokeratin 19 pseudogene that may interfere with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells

1999 • 175 citations

The detection of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction

1995 • 173 citations

The detection of micrometastases in the peripheral blood and bone marrow of patients with breast cancer using immunohistochemistry and reverse transcriptase polymerase chain reaction for keratin 19

1997 • 170 citations

Detection of minimal residual disease in patients with AML1/ETO-associated acute myeloid leukemia using a novel quantitative reverse transcription polymerase chain reaction assay

1998 • 168 citations

Melanoma-associated antigens as messenger RNA detection markers for melanoma.

1997 • 166 citations

Hematogenous Spread of Malignant Melanoma Cells in Different Stages of Disease

1993 • 166 citations

Genetic divergence in the clonal evolution of breast cancer.

1996 • 164 citations

Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro

1998 • 160 citations

The detection of disseminated tumor cells in bone marrow from colorectal-cancer patients by a cytokeratin-20-specific nested reverse-transcriptase-polymerase-chain reaction is related to the stage of disease

1996 • 160 citations

Identification of bone marrow micrometastases in patients with prostate cancer

1994 • 159 citations

Peripheral Blood Tyrosinase Messenger RNA Detection and Survival in Malignant Melanoma

1996 • 157 citations

Tumor antigens recognized by T lymphocytes

1997 • 153 citations

Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions

1994 • 151 citations

Polymerase Chain Reaction Detection of Circulating Melanocytes as a Prognostic Marker in Patients With Melanoma

1995 • 150 citations

The Analysis of Tyrosinase-Specific mRNA in Blood Samples of Melanoma Patients by RT-PCR Is Not a Useful Test for Metastic Tumor Progression

1997 • 142 citations

Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. A specific diagnostic assay.

1995 • 142 citations

Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients.

1998 • 139 citations

Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood

1995 • 133 citations

Presence of circulating prostate cells in the bone marrow of patients undergoing radical prostatectomy is predictive of disease-free survival.

1997 • 130 citations

A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.

1995 • 129 citations

Chaos and the evolution of cooperation.

1993 • 128 citations

Detection of colorectal cancer cells in peripheral blood by reverse-transcriptase polymerase chain reaction for cytokeratin 20

1998 • 128 citations

Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5.

1998 • 127 citations

Polymerase chain reaction detection of melanoma cells in the circulation: relation to clinical stage, surgical treatment, and recurrence from melanoma.

1998 • 126 citations

Prognostic significance of peripheral blood and bone marrow tyrosinase messenger RNA in malignant melanoma.

1998 • 125 citations

Reliability of reverse transcription-polymerase chain reaction (RT-PCR)-based assays for the detection of circulating tumour cells: a quality-assurance initiative of the EORTC melanoma cooperative group

1998 • 123 citations

Detection of micrometastases in colorectal cancer patients by K19 and K20 reverse-transcription polymerase chain reaction.

1996 • 120 citations

Detection of K-ras Oncogene Mutations in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis

1995 • 118 citations

Molecular Diagnosis of Residual and Recurrent Thyroid Cancer by Amplification of Thyroglobulin Messenger Ribonucleic Acid in Peripheral Blood¹

1998 • 118 citations

Detection of intraoperative tumor cell dissemination in patients with breast cancer by use of reverse transcription and polymerase chain reaction

1995 • 116 citations

Detection of neuroblastoma cells in bone marrow and peripheral blood at diagnosis by the reverse transcriptase-polymerase chain reaction for tyrosine hydroxylase mRNA

1995 • 115 citations

Common patterns of genetic evolution in human solid tumors

1997 • 115 citations

Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice

1997 • 115 citations

RETRACTED: The TSG101 Tumor Susceptibility Gene Is Located in Chromosome 11 Band p15 and Is Mutated in Human Breast Cancer

1997 • 114 citations

Aberrant splicing but not mutations of TSG101 in human breast cancer.

1997 • 113 citations

Neuroblastoma cell detection by reverse transcriptase‐polymerase chain reaction (RT‐PCR) for tyrosine hydroxylase mRNA

1994 • 111 citations

Molecular and biochemical analysis of RET/PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer.

1996 • 110 citations

Detection of tyrosine hydroxylase mRNA and minimal neuroblastoma cells by the reverse transcription-polymerase chain reaction

1991 • 109 citations

Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia

1991 • 106 citations

Diagnosis of micrometastases by the amplification of tissue-specific genes

1995 • 105 citations

Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR

1996 • 104 citations

Spread of colorectal cancer micrometastases in regional lymph nodes by reverse transcriptase-polymerase chain reactions for carcinoembryonic antigen and cytokeratin 20

1998 • 103 citations

RT-PCR for Tyrosinase-mRNA-Positive Cells in Peripheral Blood: Evaluation Strategy and Correlation with Known Prognostic Markers in 123 Melanoma Patients

1998 • 102 citations

Detection of K-ras Mutation in Colonic Effluent Samples From Patients Without Evidence of Colorectal Carcinoma

1994 • 102 citations

Evaluation of tyrosinase mRNA as a tumor marker in the blood of melanoma patients.

1997 • 100 citations

Identification of carcinoembryonic antigen-producing cells circulating in the blood of patients with colorectal carcinoma by reverse transcriptase polymerase chain reaction.

1996 • 99 citations

Reverse Transcriptase Polymerase Chain Reaction for Prostate Specific Antigen in the Management of Prostate Cancer

1997 • 98 citations

Detection of colonic cells in peripheral blood of colorectal cancer patients by means of reverse transcriptase and polymerase chain reaction

1998 • 98 citations

Gene fusions encoding chimaeric transcription factors in solid tumours

1996 • 97 citations

Enhanced detection of hematogenous circulating prostatic cells in patients with prostate adenocarcinoma by using nested reverse transcription polymerase chain reaction assay based on prostate-specific membrane antigen

1995 • 96 citations

Sensitive detection of circulating breast cancer cells by reverse-transcriptase polymerase chain reaction of maspin gene

1996 • 92 citations

Reverse transcriptase/polymerase chain reaction detection of cytokeratin-19 mRNA in bone marrow and blood of breast cancer patients

1996 • 91 citations

Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients.

1996 • 91 citations

Combined nested RT-PCR assay for prostate-specific antigen and prostate-specific membrane antigen in prostate cancer patients: correlation with pathological stage.

1998 • 91 citations

Detection of circulating thyroid cells in peripheral blood

1996 • 91 citations

Analysis of anomalous CD44 gene expression in human breast, bladder, and colon cancer and correlation of observed mRNA and protein isoforms.

1996 • 88 citations

Multicolor FISHing: what's the catch?

1997 • 86 citations

Detection of metastatic breast cancer by β-hCG polymerase chain reaction

1996 • 85 citations

Reverse transcriptase-polymerase chain reaction for expression of tyrosinase to identify malignant melanoma cells in peripheral blood

1996 • 85 citations

Limitations of the reverse transcription-polymerase chain reaction method for the detection of carcinoembryonic antigen-positive tumor cells in peripheral blood.

1998 • 84 citations

Detection of the EWS/WT1 Gene Fusion by Reverse Transcriptase-Polymerase Chain Reaction in the Diagnosis of Intra-abdominal Desmoplastic Small Round Cell Tumor

1996 • 80 citations

Diagnosis of Synovial Sarcoma with the Reverse Transcriptase-Polymerase Chain Reaction

1998 • 80 citations

Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer

1997 • 79 citations

Assessment of microsatellite instability in urine in the detection of transitional-cell carcinoma of the bladder

1998 • 79 citations

Hematogenous spreading of hepatocellular carcinoma cells: Possible participation in recurrence in the liver

1997 • 77 citations

Expression of prostate-specific antigen and prostate-specific membrane antigen transcripts in blood cells: implications for the detection of hematogenous prostate cells and standardization

1998 • 76 citations

Restriction Endonuclease-Mediated Selective Polymerase Chain Reaction

1998 • 76 citations

Detection of cytokeratin-19 transcripts by reverse transcriptase-polymerase chain reaction in lung cancer cell lines and blood of lung cancer patients.

1997 • 76 citations

Sequential detection of tumor cells in the peripheral blood and bone marrow of patients with stage IV neuroblastoma by the reverse transcription-polymerase chain reaction for tyrosine hydroxylase mRNA

1996 • 73 citations

Detection of circulating prostate cells by reverse transcriptase-polymerase chain reaction of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) Messages

1997 • 72 citations

Increased analytical sensitivity of RT-PCR of PSA mRNA decreases diagnostic specificity of detection of prostatic cells in blood

1997 • 70 citations

Detection of human telomerase reverse transcriptase messenger RNA in voided urine samples as a useful diagnostic tool for bladder cancer.

1998 • 69 citations

Tyrosinase Gene Expression in Human Tissues

1993 • 68 citations

Prognostic value of CD44 splice variants in human stage III cervical cancer

1995 • 68 citations

A new form of RET rearrangement in thyroid carcinomas of children after the Chernobyl reactor accident.

1996 • 68 citations

Detection of melanocytes from uveal melanoma in peripheral blood using the polymerase chain reaction.

1993 • 67 citations

Cytokeratin 20: a new marker for early detection of bladder cell carcinoma?

1998 • 66 citations

Detection of human papillomavirus mRNA and cervical cancer cells in peripheral blood of cervical cancer patients with metastasis.

1997 • 65 citations

Detection of Residual Tumor Cells in Patients with Malignant Melanoma Responding to Immunotherapy

1994 • 65 citations

Semiquantification of circulating hepatocellular carcinoma cells by reverse transcriptase polymerase chain reaction

1997 • 64 citations

Evaluation of breast tumour cell contamination in the bone marrow and leukapheresis collections by RT‐PCR for cytokeratin‐19 mRNA

1998 • 64 citations

Molecular assessment of tumour stage and disease recurrence using PCR-based assays

1998 • 64 citations

Identification of carcinoembryonic antigen mRNA in circulating peripheral blood of pancreatic carcinoma and gastric carcinoma patients

1996 • 63 citations

Abnormal expression of CD44 variants in the exfoliated cells in the feces of patients with colorectal cancer

1998 • 63 citations

Detection of Neuroblastoma cells in CD34+ selected peripheral stem cells using a combination of tyrosine hydroxylase nested RT–PCR and anti-Ganglioside GD2 immunocytochemistry

1997 • 62 citations

Keratin 19 mRNA measurement to detect micrometastases in lymph nodes in breast cancer patients

1996 • 60 citations

Transrectal ultrasound-guided biopsy causes hematogenous dissemination of prostate cells as determined by RT-PCR

1997 • 60 citations

Reverse transcriptase-polymerase chain reaction analysis of cytokeratin 19 expression in the peripheral blood mononuclear cells of normal female blood donors.

1997 • 59 citations

Prognostic significance of the RT-PCR assay of PML-RARA transcripts in acute promyelocytic leukemia. The Leukemia Study Group of the Ministry of Health and Welfare (Kouseisho).

1995 • 59 citations

Feedback theory and Darwinian evolution

1991 • 58 citations

Early development of human Merkel cells

1992 • 58 citations

Immunobead RT-PCR: A Sensitive Method for Detection of Circulating Tumor Cells

1997 • 57 citations

Putative markers for the detection of breast carcinoma cells in blood

1998 • 57 citations

Detection of Occult Breast Cancer Micrometastases in Axillary Lymph Nodes Using a Multimarker Reverse Transcriptase-Polymerase Chain Reaction Panel

1998 • 57 citations

Genetic detection of colorectal cancer cells in circulation and lymph nodes

1997 • 56 citations

Genetic detection of lymph node micrometastases in patients with colorectal cancer

1998 • 55 citations

Positive prostate-specific antigen circulating cells detected by reverse transcriptasepolymerase chain reaction does not imply the presence of prostatic micrometastase s

1997 • 55 citations

Molecular cytogenetic characterization of cancer cell alterations

1997 • 55 citations

Reverse transcriptase-polymerase chain reaction (RT-PCR)-controlled immunomagnetic purging of breast cancer cells using the magnetic cell separation (MACS) system: a sensitive method for monitoring purging efficiency.

1997 • 54 citations

The Expression of Prostate-Specific Membrane Antigen in Peripheral Blood Leukocytes

1997 • 54 citations

Early clinical evaluation of neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction (RT-PCR) for tyrosine hydroxylase mRNA

1995 • 54 citations

Detection of tyrosinase mRNA from the blood of melanoma patients.

1996 • 54 citations

Can a test for E6/E7 transcripts of human papillomavirus type 16 serve as a diagnostic tool for the detection of micrometastasis in cervical cancer?

1995 • 53 citations

Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis

1995 • 53 citations

Surfactant protein gene expression in metastatic and micrometastatic pulmonary adenocarcinomas and other non-small cell lung carcinomas: Detection by reverse transcriptase-polymerase chain reaction

1996 • 53 citations

Diagnosis of pancreatic adenocarcinoma by polymerase chain reaction from pancreatic secretions

1994 • 53 citations

Recent Discoveries in Cancer Genetics of Exocrine Pancreatic Neoplasia

1998 • 53 citations

Prostate-specific membrane antigen: current and future utility.

1998 • 52 citations

Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia

1998 • 52 citations

Detection of regional lymph node metastases in colon cancer by using RT-PCR for matrix metalloproteinase 7, matrilysin.

1997 • 51 citations

Lung cancer metastatic cells detected in blood by reverse transcriptase-polymerase chain reaction and dot-blot analysis.

1997 • 50 citations

Frequent abnormalities of TSG101 transcripts in human prostate cancer

1997 • 50 citations

Genetic Instability and Chromosomal Aberrations in Colorectal Cancer: A Review of the Current Models

1998 • 49 citations

Detection of Minimal Disease in Patients with Solid Tumors

1996 • 49 citations

CD44 is an independent prognostic factor in early-stage cervical cancer

1997 • 49 citations

Sensitive Assay for Detection of Hepatocellular Carcinoma Associated Gene Transcription (α-Fetoprotein mRNA) in Blood

1995 • 48 citations

Analysis of FUS-CHOP fusion transcripts in different types of soft tissue liposarcoma and their diagnostic implications.

1998 • 47 citations

K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases

1998 • 47 citations

Detection of Gene Fusions in Rhabdomyosarcoma by Reverse Transcriptase-Polymerase Chain Reaction Assay of Archival Samples

1997 • 47 citations

Epithelial tumour cell detection and the unsolved problems of nested RT-PCR: a new sensitive one step method without false positive results

1998 • 43 citations

Molecular monitoring of tumor cell contamination in leukapheresis products from stage IV neuroblastoma patients before and after positive CD34 selection

1998 • 43 citations

The molecular genetics of pancreatic cancer

1997 • 42 citations

Restricted expression of oncofetal fibronectin mRNA in thyroid papillary and anaplastic carcinoma: an in situ hybridization study

1998 • 41 citations

REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION ASSAYS FOR PROSTATE CANCER

1997 • 41 citations

Expression of -Fetoprotein and Prostate-specific Antigen Genes in Several Tissues and Detection of mRNAs in Normal Circulating Blood by Reverse Transcriptase-Polymerase Chain Reaction

1998 • 41 citations

A new CD44v3-containing isoform is involved in tumor cell growth and migration during human breast carcinoma progression

1999 • 41 citations

Detection of micrometastatic prostate cancer cells in the bone marrow of patients with prostate cancer

1997 • 40 citations

Detection of circulating tumour cells and nodal metastasis by reverse transcriptase-polymerase chain reaction technique.

1997 • 39 citations

Detection of β-human chorionic gonadotropin mRNA as a marker for cutaneous malignant melanoma

1996 • 39 citations

Detection of cancer cells in peripheral blood of breast cancer patients using reverse transcription-polymerase chain reaction for epidermal growth factor receptor.

1998 • 39 citations

Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: Common types of shorter transcripts are true alternative splice variants

1998 • 38 citations

Disseminierte Tumorzellen: Diagnostik, prognostische Relevanz, Phänotypisierung und therapeutische Strategien

1997 • 38 citations

Detection of prostate-specific antigen mRNA and protein in breast tumors

1996 • 38 citations

Frequent detection of ras and p53 mutations in brush cytology samples from lung cancer patients by a restriction fragment length polymorphism-based "enriched PCR" technique.

1998 • 38 citations

Polymerase chain reaction is highly predictive of relapse in patients following T cell-depleted allogeneic bone marrow transplantation for chronic myeloid leukemia.

1996 • 37 citations

TSG101 is not mutated in lung cancer but a shortened transcript is frequently expressed in small cell lung cancer

1998 • 37 citations

Minimal residual disease in chronic myeloid leukaemia.

1998 • 37 citations

Very low level of major BCR-ABL expression in blood of some healthy individuals.

1996 • 37 citations

Detection and quantitation of melanoma cells in the circulation of patients

1996 • 37 citations

Molecular Monitoring of Residual Disease in Chronic Myelogenous Leukemia Patients After Therapy

1998 • 36 citations

Preoperative diagnosis of thyroid papillary carcinoma by reverse transcriptase polymerase chain reaction of theMUC1 gene

1996 • 36 citations

Minimal illegitimate levels of cytokeratin K19 expression in mononucleated blood cells detected by a reverse transcription PCR method (RT-PCR)

1997 • 36 citations

Clinical application of minimal residual neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction

1997 • 35 citations

Reverse transcriptase-polymerase chain reaction for prostate-specific antigen may be a prognostic indicator in breast cancer

1996 • 35 citations

The Role of CD44 Splice Variants in Human Metastatic Cancer

2007 • 34 citations

Oncogenic Role of “Master” Transcription Factors in Human Leukemias And Sarcomas: A Developmental Model

1995 • 34 citations

Quality management and influential factors for the detection of single metastatic cancer cells by reverse transcriptase polymerase chain reaction.

1997 • 34 citations

Self-organisation of living systems towards criticality at the edge of chaos

1994 • 32 citations

Expression of CD44 splice variants in normal respiratory epithelium and bronchial carcinomas: no evidence for altered CD44 splicing in metastasis.

1996 • 32 citations

Human Tumor Rejection Antigens MAGE

1996 • 32 citations

Progressing Imbalance Between Proliferation and Apoptosis with Increasing Severity of Cervical Intraepithelial Neoplasia

1997 • 31 citations

Comparison of Molecular Cytokeratin 19 Reverse Transcriptase Polymerase Chain Reaction (CK19 RT-PCR) and Immunocytochemical Detection of Micrometastatic Breast Cancer Cells in Hematopoietic Harvests

1997 • 31 citations

Value of molecular monitoring during the treatment of chronic myeloid leukemia: a Cancer and Leukemia Group B study.

1997 • 30 citations

Diagnosis and treatment of soft tissue sarcomas in adults

1995 • 30 citations

Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma

1997 • 30 citations

K-ras gene mutations in the diagnosis of fine-needle aspirates of pancreatic masses: prospective study using two techniques with different detection limits

1998 • 29 citations

Expression of CD44 splice variants in normal, dysplastic, and neoplastic cervical epithelium.

1995 • 29 citations

Fluorescence in situ hybridization: powerful molecular tool for cancer prognosis

1995 • 28 citations

Genomic Stability and Instability: A Working Paradigm

1997 • 28 citations

Detection of the PGP9.5 and Tyrosine Hydroxylase mRNAs for Minimal Residual Neuroblastoma Cells in Bone Marrow and Peripheral Blood.

1998 • 26 citations

An improved and combined reverse transcription-polymerase chain reaction assay for reliable detection of metastatic melanoma cells in peripheral blood

1997 • 26 citations

Cytogenetics and experimental models of sarcomas

1995 • 25 citations

Detection of rare human breast cancer cells. Comparison of an immunomagnetic separation method with immunocytochemistry and RT-PCR.

1997 • 25 citations

Immunohistochemical detection of adhesion molecule CD44 splice variants in lymph node metastases of cervical cancer

1996 • 24 citations

Genetic and phenotypic heterogeneity of human malignancies: Finding order in chaos

1995 • 24 citations

Detection of germ cell tumor cells in apheresis products using polymerase chain reaction.

1998 • 24 citations

FISH: recent advances and diagnostic aspects.

1998 • 24 citations

Cancer screening based on genetic alterations in human tumors.

1994 • 23 citations

K-ras mutation in sputum of patients with or without lung cancer

1996 • 23 citations

Expression of CD44 splice variants in colorectal cancer

1997 • 23 citations

Sensitive and specific cytokeratin 18 reverse transcription-polymerase chain reaction that excludes amplification of processed pseudogenes from contaminating genomic DNA

1997 • 23 citations

Cytogenetics and the biological basis of sarcomas

1998 • 23 citations

Value of the Preoperative Detection of Prostate-Specific-Antigen-Positive Circulating Cells by Nested RT-PCR in Patients Submitted to Radical Prostatectomy

1997 • 23 citations

Aberrant TSG101 transcripts in acute myeloid leukaemia

1998 • 22 citations

No evidence for cancer-related CD44 splice variants in primary and metastatic colorectal cancer

1998 • 21 citations

Molecular approaches for colorectal cancer screening

1998 • 21 citations

Molecular markers in cancer diagnosis.

1995 • 21 citations

Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique

1996 • 20 citations

CD44 splice variants: expression during lymphocyte activation and tumor progression.

1993 • 20 citations

Identification of cellular TSG101 protein in multiple human breast cancer cell lines.

1997 • 19 citations

13 Assessing residual leukaemia

1997 • 19 citations

Low frequency of TSG101/CC2 gene alterations in invasive human breast cancers

1998 • 19 citations

Highly-sensitive identification of α-fetoprotein mRNA in circulating peripheral blood of hepatocellular carcinoma patients

1995 • 19 citations

Detection of early micrometastases in subcutaneous fat of primary malignant melanoma patients by identification of tyrosinase-mRNA

1996 • 18 citations

Detection of carcinoembryonic antigen mRNA in the mesenteric vein of patients with resectable colorectal cancer

1998 • 18 citations

Early detection of minimal residual disease by reverse transcriptase polymerase chain reaction predicts relapse in acute promyelocytic leukemia

1995 • 18 citations

The role of cell death in the growth of preneoplastic lesions: a Monte Carlo simulation model

1992 • 18 citations

Detection of Occult Tumour Cells in Bone Marrow and Blood in Breast Cancer Patients

1996 • 17 citations

Polymerase chain reaction detection of circulating tumour cells. EORTC Melanoma Cooperative Group, Immunotherapy Subgroup.

1997 • 17 citations

The Use of Polymerase Chain Reaction to Detect Metastatic Cancer Cells Within Lymph Nodes in Stage I Cervical Carcinoma

1995 • 16 citations

Detection of cancer cells in peripheral blood stem cells of women with breast cancer by RT-PCR and cell culture.

1996 • 16 citations

Detection of Human Papillomavirus Type 16 E6/E7 Transcripts in Histologically Cancer-Free Pelvic Lymph Nodes of Patients with Cervical Carcinoma

1994 • 15 citations

The molecular biology of soft tissue sarcomas

1993 • 15 citations

Genetic alterations as clonal markers for bladder cancer detection in urine

1996 • 14 citations

Quantitative enriched PCR (QEPCR), a highly sensitive method for detection of K-ras oncogene mutation

1997 • 14 citations

Tumour diagnosis by PCR-based detection of tumour cells

1995 • 13 citations

Reverse Transcriptase-Polymerase Chain Reaction forbcr/ablFusion in Chronic Myelogenous Leukemia

1996 • 13 citations

Detection of Circulating Tumor Cells in Patients with Prostate Cancer Using Prostate Specific Membrane‐Derived Primers in the Polymerase Chain Reaction

1997 • 13 citations

Efficacy of current molecular cytogenetic protocols for the diagnosis of chromosome aberrations in tumor specimens.

1996 • 13 citations

Soft tissue tumours: the impact of cytogenetics and molecular genetics.

1997 • 12 citations

Diagnosis of Minimal Residual Disease in Bone Marrow and Blood in Cancer Patients: Methods and Clinical Implications

1998 • 12 citations

Absence of TSG101 transcript abnormalities in human cancers

1998 • 11 citations

Apolipoprotein A-I reverse transcriptase-polymerase chain reaction analysis for detection of hematogenous colon cancer dissemination.

1998 • 10 citations

Identical variantTSG101 transcripts in soft tissue sarcomas and various non-neoplastic tissues

1998 • 9 citations

Detection of melanoma cells in peripheral blood stem cell harvests of patients with progressive metastatic malignant melanoma

1997 • 8 citations

Detection of neuroblastoma cells in blood by reverse transcriptase-polymerase chain reaction.

1997 • 8 citations

Cytogenetic and Molecular Analysis of Pediatric Neoplasms: Diagnostic and Clinical Implications

1994 • 8 citations

Optimization of the tyrosinase mRNA probe to detect circulating melanocytes with reverse transcription and polymerase chain reaction.

1998 • 7 citations

Development of Cancer Vaccine by Tumor Rejection Antigens

1997 • 7 citations

The value of the presence of HPV16 in pelvic lymph nodes of cervical cancer patients.

1995 • 6 citations

Restriction Digest PCR (RD-PCR) for the Analysis of Gene Mutations. Application to Ki-ras

1998 • 5 citations

Comparison of AFP and β-hCG levels in infiltrating duct mammary carcinoma at different stages of malignancy

1988 • 4 citations

Detection of bcr-abl fusion mRNA in chronic myelogenous leukemia by reverse transcription polymerase chain reaction using nested primers.

1993 • 3 citations

[Molecular diagnostic detection of circulating tumor cells and their prognostic implications].

1997 • 1 citations

Rudolf-Virchow-Preis 1996. Priesträgerrede. Detection of surfactant protein gene expression by reverse transcriptase-polymerase chain reaction (RT-PCR) identifies metastases and occult tumor spread of pulmonary adenocarcinomas.

1996 • 1 citations