Utilization of polymerase chain reaction technology in the detection of solid tumors

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

Bone marrow transplant

1997 • 3,583 citations

Prostate-Specific Antigen as a Serum Marker for Adenocarcinoma of the Prostate

1987 • 2,447 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Cancer statistics, 1997

1997 • 2,045 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Cancer: Principles and Practice of Oncology

1997 • 1,408 citations

The Polymerase Chain Reaction

1990 • 1,198 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

Viruses in Human Cancers

1991 • 793 citations

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

1974 • 775 citations

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

1988 • 741 citations

A Prospective Evaluation of Plasma Prostate-Specific Antigen for Detection of Prostatic Cancer

1995 • 735 citations

Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors

1992 • 703 citations

Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction

1991 • 658 citations

Microsatellite alterations in serum DNA of head and neck cancer patients

1996 • 653 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products

1991 • 556 citations

Significance of CD44 gene products for cancer diagnosis and disease evaluation

1992 • 470 citations

Microsatellite alterations as clonal markers for the detection of human cancer.

1994 • 448 citations

Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.

1994 • 443 citations

Detection of Minimal Residual Cells Carrying the t(14;18) by DNA Sequence Amplification

1987 • 426 citations

Molecular Detection of Primary Bladder Cancer by Microsatellite Analysis

1996 • 396 citations

Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction.

1994 • 382 citations

Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.

1993 • 380 citations

Detection of hematogenous micrometastasis in patients with prostate cancer.

1992 • 374 citations

Detection of bcr - abl Fusion in Chronic Myelogeneous Leukemia by in Situ Hybridization

1990 • 371 citations

Detection of cancer micrometastases in lymph nodes by reverse transcriptase-polymerase chain reaction.

1995 • 366 citations

Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa.

1994 • 349 citations

Detection of epithelial cancer cells in peripheral blood by reverse transcriptase-polymerase chain reaction

1995 • 343 citations

Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease.

1988 • 341 citations

Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay.

1995 • 338 citations

Molecular Basis of Human B Cell Neoplasia

1985 • 316 citations

Spread of prostatic cancer to bone

1983 • 289 citations

Detection of Submicroscopic Lymph Node Metastases with Polymerase Chain Reaction in Patients with Malignant Melanoma

1994 • 280 citations

Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.

1989 • 275 citations

Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction.

1994 • 271 citations

Sensitive nested reverse transcription polymerase chain reaction detection of circulating prostatic tumor cells: comparison of prostate-specific membrane antigen and prostate-specific antigen-based assays.

1994 • 241 citations

Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas

1989 • 240 citations

POLYMERASE CHAIN REACTION STRATEGY

1992 • 225 citations

Detection of circulating tumor cells in patients with localized and metastatic prostatic carcinoma: clinical implications.

1995 • 220 citations

Keratin gene expression in non-epithelial tissues. Detection with polymerase chain reaction.

1993 • 208 citations

Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues

1996 • 204 citations

Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine

1997 • 204 citations

Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease

1996 • 201 citations

Detection of circulating neoplastic cells by reverse-transcriptase polymerase chain reaction in malignant melanoma: association with clinical stage and prognosis.

1996 • 196 citations

Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology

1993 • 193 citations

Sensitive detection of rare circulating neuroblastoma cells by the reverse transcriptase-polymerase chain reaction.

1992 • 190 citations

Clinical significance of bone marrow metastases as detected using the polymerase chain reaction in patients with breast cancer undergoing high-dose chemotherapy and autologous bone marrow transplantation.

1996 • 188 citations

Detection of breast cancer micrometastases in axillary lymph nodes by means of reverse transcriptase-polymerase chain reaction. Comparison between MUC1 mRNA and keratin 19 mRNA amplification.

1996 • 187 citations

Prostate-specific antigen in milk of lactating women

1995 • 186 citations

Detection of circulating tumor cells in men with localized prostate cancer.

1994 • 180 citations

The detection of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction

1995 • 173 citations

Melanoma-associated antigens as messenger RNA detection markers for melanoma.

1997 • 166 citations

Mutations in the p53 gene in primary human breast cancers.

1991 • 165 citations

Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction.

1993 • 164 citations

Molecular and immunological detection of circulating tumor cells and micrometastases from solid tumors

1996 • 163 citations

The detection of disseminated tumor cells in bone marrow from colorectal-cancer patients by a cytokeratin-20-specific nested reverse-transcriptase-polymerase-chain reaction is related to the stage of disease

1996 • 160 citations

Identification of bone marrow micrometastases in patients with prostate cancer

1994 • 159 citations

Peripheral Blood Tyrosinase Messenger RNA Detection and Survival in Malignant Melanoma

1996 • 157 citations

Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction

1994 • 153 citations

Germline BRCA1 185delAG mutations in Jewish women with breast cancer

1996 • 152 citations

Detection of micrometastatic prostate cancer cells in lymph nodes by reverse transcriptase-polymerase chain reaction.

1993 • 152 citations

Polymerase Chain Reaction Detection of Circulating Melanocytes as a Prognostic Marker in Patients With Melanoma

1995 • 150 citations

Comparison of immunohistochemistry and RT‐PCR for detection of CD44v‐expression, a new prognostic factor in human breast cancer

1995 • 150 citations

Reverse Transcriptase PCR Amplification of EWS/FLI-1 Fusion Transcripts as a Diagnostic Test for Peripheral Primitive Neuroectodermal Tumors of Childhood

1993 • 148 citations

The Analysis of Tyrosinase-Specific mRNA in Blood Samples of Melanoma Patients by RT-PCR Is Not a Useful Test for Metastic Tumor Progression

1997 • 142 citations

Prostate-specific antigen messenger RNA is expressed in non-prostate cells: implications for detection of micrometastases.

1995 • 142 citations

Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Special reference to its detection by the polymerase chain reaction and in situ hybridization in 99 tumors, including a morphologic analysis

1994 • 141 citations

Reverse Transcriptase PCR Amplification of EWS/FLI-1 Fusion Transcripts as a Diagnostic Test for Peripheral Primitive Neuroectodermal Tumors of Childhood

1993 • 140 citations

New CD44 splice variants associated with human breast cancers

1995 • 136 citations

Processing of long-stored archival cervical smears for human papillomavirus detection by the polymerase chain reaction

1995 • 135 citations

Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood

1995 • 133 citations

Detection of JC virus DNA sequence and expression of the viral oncoprotein, tumor antigen, in brain of immunocompetent patient with oligoastrocytoma.

1996 • 131 citations

A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.

1995 • 129 citations

Clinical impact of detection of loss of heterozygosity of BRCA1 and BRCA2 markers in sporadic breast cancer

1996 • 121 citations

Molecular Detection of Prostate Epithelial Cells from the Surgical Field and Peripheral Circulation during Radical Prostatectomy

1996 • 120 citations

Telomerase activity in human breast cancer and benign breast lesions: Diagnostic applications in clinical specimens, including fine needle aspirates

1996 • 120 citations

Enhanced reverse transcriptase-polymerase chain reaction for prostate specific antigen as an indicator of true pathologic stage in patients with prostate cancer

1995 • 120 citations

Detection of micrometastases in colorectal cancer patients by K19 and K20 reverse-transcription polymerase chain reaction.

1996 • 120 citations

Detection of Circulating Tumor Cells in Colorectal Cancer by Immunobead-PCR Is a Sensitive Prognostic Marker for Relapse of Disease

1995 • 117 citations

Detection of neuroblastoma cells in bone marrow and peripheral blood at diagnosis by the reverse transcriptase-polymerase chain reaction for tyrosine hydroxylase mRNA

1995 • 115 citations

Detection of Point Mutations in the Kirsten-ras Oncogene Provides Evidence for the Multicentricity of Pancreatic Carcinoma

1993 • 114 citations

Detection of Philadelphia chromosome-positive acute lymphoblastic leukemia by polymerase chain reaction: possible eradication of minimal residual disease by marrow transplantation

1992 • 113 citations

Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene.

1995 • 113 citations

Detection of telomerase activity in oral rinses from head and neck squamous cell carcinoma patients.

1996 • 110 citations

Distinguishing Pancreatic Carcinoma From Other Periampullary Carcinomas by Analysis of Mutations in the Kirsten-ras Oncogene

1991 • 109 citations

Detection of tyrosine hydroxylase mRNA and minimal neuroblastoma cells by the reverse transcription-polymerase chain reaction

1991 • 109 citations

Analysis of cytomorphologically abnormal cervical scrapes for the presence of 27 mucosotropic human papillomavirus genotypes, using polymerase chain reaction

1994 • 108 citations

DETECTION OF RESIDUAL bcr/abl TRANSLOCATION BY POLYMERASE CHAIN REACTION IN CHRONIC MYELOID LEUKAEMIA PATIENTS AFTER BONE-MARROW TRANSPLANTATION

1989 • 106 citations

Diagnosis of micrometastases by the amplification of tissue-specific genes

1995 • 105 citations

Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma.

1995 • 104 citations

Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR

1996 • 104 citations

Preoperative Reverse Transcriptase Polymerase Chain Reaction for Prostate Specific Antigen Predicts Treatment Failure Following Radical Prostatectomy

1996 • 103 citations

Detection of HHV-8/KSHV DNA sequences in AIDS-associated extranodal lymphoid malignancies.

1996 • 101 citations

Identification of carcinoembryonic antigen-producing cells circulating in the blood of patients with colorectal carcinoma by reverse transcriptase polymerase chain reaction.

1996 • 99 citations

Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer

1996 • 99 citations

Reverse Transcriptase Polymerase Chain Reaction for Prostate Specific Antigen in the Management of Prostate Cancer

1997 • 98 citations

Enhanced detection of hematogenous circulating prostatic cells in patients with prostate adenocarcinoma by using nested reverse transcription polymerase chain reaction assay based on prostate-specific membrane antigen

1995 • 96 citations

Expression of N-myc by neuroblastomas with one or multiple copies of the oncogene.

1988 • 95 citations

Sensitive detection of circulating breast cancer cells by reverse-transcriptase polymerase chain reaction of maspin gene

1996 • 92 citations

Reverse transcriptase/polymerase chain reaction detection of cytokeratin-19 mRNA in bone marrow and blood of breast cancer patients

1996 • 91 citations

Detection of circulating thyroid cells in peripheral blood

1996 • 91 citations

Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients.

1996 • 91 citations

Retinoblastoma gene mutations in primary human bladder cancer

1995 • 88 citations

Detection of liver cells in peripheral blood of patients with advanced-stage hepatocellular carcinoma*1

1995 • 87 citations

Expression of CD44 isoforms in renal cell tumors. Positive correlation to tumor differentiation.

1996 • 86 citations

Detection of metastatic breast cancer by β-hCG polymerase chain reaction

1996 • 85 citations

Reverse transcriptase-polymerase chain reaction for expression of tyrosinase to identify malignant melanoma cells in peripheral blood

1996 • 85 citations

High frequency of K‐ras mutations in normal appearing lung tissues and sputum of patients with lung cancer

1995 • 83 citations

Molecular staging of prostate cancer. II. A comparison of the application of an enhanced reverse transcriptase polymerase chain reaction assay for prostate specific antigen versus prostate specific membrane antigen.

1995 • 83 citations

Detection of telomerase activity in exfoliated cancer cells in colonic luminal washings and its related clinical implications

1997 • 82 citations

Sensitive Detection of Prostatic Hematogenous Tumor Cell Dissemination Using Prostate Specific Antigen and Prostate Specific Membrane-Derived Primers in the Polymerase Chain Reaction

1995 • 82 citations

Detection of Gastric Cancer Micrometastases in Lymph Nodes by Amplification of Keratin 19 mRNA with Reverse Transcriptase‐Polymerase Chain Reaction

1996 • 82 citations

Detection of the EWS/WT1 Gene Fusion by Reverse Transcriptase-Polymerase Chain Reaction in the Diagnosis of Intra-abdominal Desmoplastic Small Round Cell Tumor

1996 • 80 citations

Detection of prostatic cells in peripheral blood: correlation with serum concentrations of prostate-specific antigen

1995 • 77 citations

Hematogenous spreading of hepatocellular carcinoma cells: Possible participation in recurrence in the liver

1997 • 77 citations

Mechanisms and therapeutic implications of angiogenesis

1996 • 77 citations

The Role of Chromosomal Translocations in B- and T-Cell Neoplasia

1987 • 76 citations

Sequential detection of tumor cells in the peripheral blood and bone marrow of patients with stage IV neuroblastoma by the reverse transcription-polymerase chain reaction for tyrosine hydroxylase mRNA

1996 • 73 citations

Direct detection of mutations in the breast and ovarian cancer susceptibility gene BRCA1 by PCR-mediated site-directed mutagenesis

1997 • 73 citations

Circulating Prostate Specific Antigen‐positive Cells Correlate with Metastatic Prostate Cancer

1992 • 69 citations

Detection of human papillomavirus DNA and p53 gene mutations in human prostate cancer

1996 • 68 citations

Conventional Urodynamics and Ambulatory Monitoring in the Definition and Management of Bladder Outflow Obstruction

1996 • 66 citations

Sensitivity of immunohistochemistry and polymerase chain reaction in detecting prostate cancer cells in bone marrow.

1994 • 66 citations

Detection of Residual Tumor Cells in Patients with Malignant Melanoma Responding to Immunotherapy

1994 • 65 citations

gelatinase A/TIMP‐2 imbalance in lymph‐node‐positive breast carcinomas, as measured by RT‐PCR

1995 • 65 citations

Detection of human papillomavirus mRNA and cervical cancer cells in peripheral blood of cervical cancer patients with metastasis.

1997 • 65 citations

Clinical evaluation of a DNA probe assay for the Philadelphia (Ph1) translocation in chronic myelogenous leukemia.

1988 • 64 citations

Detection of K-ras Point Mutations at Codon 12 in Pure Pancreatic Juice for the Diagnosis of Pancreatic Cancer by PCR-RFLP Analysis

1996 • 63 citations

Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.

1996 • 63 citations

Identification of carcinoembryonic antigen mRNA in circulating peripheral blood of pancreatic carcinoma and gastric carcinoma patients

1996 • 63 citations

Molecular Stating of Prostate Cancer. II. A Comparison of the Application of an Enhanced Reverse Transcriptase Polymerase Chain Reaction Assay for Prostate Specific Antigen Versus Prostate Specific Membrane Antigen

1995 • 63 citations

Frequency and characterization of p53 mutations in clinically localized prostate cancer

1995 • 62 citations

Detection of t(11;22)(q24;ql2) Translocation Breakpoint in Paraffin-embedded Tissue of the Ewingʼs Sarcoma Family by Nested Reverse Transcription-Polymerase Chain Reaction

1996 • 61 citations

Transrectal ultrasound-guided biopsy causes hematogenous dissemination of prostate cells as determined by RT-PCR

1997 • 60 citations

EWS‐FLI‐1 and EWS‐ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor

1995 • 57 citations

Detection of Hepatic Micrometastasis in Pancreatic Adenocarcinoma Patients by Two‐stage Polymerase Chain Reaction/Restriction Fragment Length Polymorphism Analysis

1995 • 56 citations

Molecular cytogenetic characterization of cancer cell alterations

1997 • 55 citations

Mutational activation of the c-K-ras gene in human pancreatic carcinoma

1990 • 54 citations

Detection of tyrosinase mRNA from the blood of melanoma patients.

1996 • 54 citations

Can a test for E6/E7 transcripts of human papillomavirus type 16 serve as a diagnostic tool for the detection of micrometastasis in cervical cancer?

1995 • 53 citations

Expression of CD44 abnormal transcripts in human gastric carcinomas

1994 • 53 citations

p53 mutations have no additional prognostic value over stage in bladder cancer

1994 • 53 citations

Polymerase Chain Reaction-Based K-rasMutation Detection of Pancreatic Adenocarcinoma in Routine Cytology Smears

1996 • 52 citations

Detection of heterozygous truncating mutations in the BRCA1 and APC genes by using a rapid screening assay in yeast

1997 • 52 citations

Detection of microsatellite instability in human colorectal carcinomas using a non-radioactive PCR-based screening technique

1995 • 51 citations

Quantitation of alpha-fetoprotein and albumin messenger RNA in human hepatocellular carcinoma

1996 • 50 citations

Detection of circulating prostate-specific antigen-positive cells in patients with prostate cancer by flow cytometry and reverse transcription polymerase chain reaction

1996 • 49 citations

Sensitive Assay for Detection of Hepatocellular Carcinoma Associated Gene Transcription (α-Fetoprotein mRNA) in Blood

1995 • 48 citations

Detection of colorectal carcinoma cells in circulating peripheral blood by reverse transcription-polymerase chain reaction targeting cytokeratin-20 mRNA

1997 • 48 citations

Detection of circulating tumor cells in multiple myeloma by a PCR-based method.

1993 • 47 citations

High prevalence of human papillomavirus in squamous cell carcinoma and matched normal esophageal mucosa. Assessment by polymerase chain reaction

1995 • 47 citations

PCR-based approaches for detection of mutated ras genes.

1992 • 46 citations

Hepatitis C and B virus infections in hepatocellular carcinoma: Analysis of direct detection of viral genome in paraffin embedded tissues

1996 • 45 citations

Differential expression of mRNAs for endothelin-related proteins in human endometrium, myometrium and leiomyoma

1994 • 45 citations

CD44 expression patterns in breast and colon tumors: A pcr‐based study of splice variants

1995 • 44 citations

Prognostic value oferb-B2 andmyc amplification in breast cancer imprints

1995 • 43 citations

Analyses of p53 gene mutations in primary human bladder cancer.

1993 • 43 citations

Detection of ras Gene Mutations in Perioperative Peripheral Blood with Pancreatic Adenocarcinoma

1996 • 43 citations

High-sensitivity Detection of Minimal Residual Breast Carcinoma Using the Polymerase Chain Reaction and Primers for Cytokeratin 19

1996 • 40 citations

Rapid Detection of MYCN Gene Amplification in Neuroblastomas Using the Polymerase Chain Reaction

1992 • 40 citations

Immunosuppressive cytokines (IL-10, TGF-β) genes expression in human gastric carcinoma tissues

1996 • 40 citations

Detection of micrometastatic prostate cancer cells in the bone marrow of patients with prostate cancer

1997 • 40 citations

Ki-ras and p53 Mutations in Pancreatic Ductal Adenocarcinoma

1996 • 40 citations

Microsatellite instability in human cancer.

1995 • 39 citations

Hepatitis C virus infection in hepatocellular carcinoma. Detection of plus-strand and minus-strand viral RNA

1992 • 39 citations

Detection of β-human chorionic gonadotropin mRNA as a marker for cutaneous malignant melanoma

1996 • 39 citations

Gene amplification detected in carcinoma cells from human urinary bladder washings by the polymerase chain reaction method

1993 • 37 citations

Analysis of deletion of the integrated human papillomavirus 16 sequence in cervical cancer: A rapid multiplex polymerase chain reaction approach

1994 • 37 citations

The deleted in colon cancer (DCC) gene is consistently expressed in colorectal cancers and metastases.

1996 • 37 citations

p53 Gene Mutation in Recurrent Superficial Bladder Cancer

1995 • 37 citations

Amplification of N-myc sequences in primary human neuroblastomas: correlation with advanced disease stage.

1985 • 37 citations

Preoperative diagnosis of thyroid papillary carcinoma by reverse transcriptase polymerase chain reaction of theMUC1 gene

1996 • 36 citations

Prognostic significance of detection of monoclonality in remission marrow in acute lymphoblastic leukemia in childhood. Australian and New Zealand Children's Cancer Study Group.

1993 • 35 citations

Clinical application of minimal residual neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction

1997 • 35 citations

Reverse transcriptase-polymerase chain reaction for prostate-specific antigen may be a prognostic indicator in breast cancer

1996 • 35 citations

Decreased expression of messenger RNAs encoding endothelin receptors and neutral endopeptidase 24.11 in endometrial cancer

1995 • 34 citations

Appearance and detection of multiple copies of the mdr‐1 gene in clinical samples of mammary carcinoma

1992 • 34 citations

Differential CD44 expression patterns in primary brain tumours and brain metastases

1995 • 33 citations

Polymerase chain reaction-based methods for the detection of mutations in oncogenes and tumor suppressor genes

1994 • 33 citations

Rapid Detection of MYCN Gene Amplification in Neuroblastomas Using the Polymerase Chain Reaction

1992 • 32 citations

Noninvasive detection of putative biomarkers for colon cancer using fecal messenger RNA.

1995 • 31 citations

Deranged activity of the CD44 gene and other loci as biomarkers for progression to metastatic malignancy

1993 • 28 citations

A rapid and simple method for the detection of prostate-specific antigen mrna in archival tissue specimens using a reverse transcription-polymerase chain reaction assay

1995 • 28 citations

HPV and p53 in cervical cancer.

1994 • 27 citations

Detection of HER-2/neu oncogene amplification in flow cytometry-sorted breast ductal cells by competitive polymerase chain reaction

1994 • 26 citations

Detection of exfoliated carcinoma cells in colonic luminal washings by identification of deranged patterns of expression of the CD44 gene.

1996 • 26 citations

A Polymerase Chain Reaction-based Assay for the Rapid Detection of Gene Amplification in Human Tumors

1996 • 26 citations

Detection of Minimal Residual Disease in Acute Myelogenous Leukemia

1995 • 25 citations

Detection ofHelicobacter pyloriin Paraffin-Embedded Gastric Biopsy Specimens byIn SituHybridization

1996 • 25 citations

Detection of human papillomavirus DNA in fine‐needle aspirations of metastatic squamous‐cell carcinoma of the uterine cervix using the polymerase chain reaction

1989 • 25 citations

High‐level Expression of the CD44 Variant Sharing Exon v10 in Renal Cancer

1995 • 25 citations

Human Papillomavirus Detection in Cervical Carcinoma Tissues and Paraaortic Lymph Nodes by the Polymerase Chain Reaction

1994 • 25 citations

Amplification of stromelysin-3 transcripts from carcinomas of the colon

1996 • 21 citations

Detection of human herpesvirus-6 in paraffin-embedded tissue of cervical cancer by polymerase chain reaction

1994 • 21 citations

Detection of minimal residual disease by polymerase chain reaction in b cell malignancies

1995 • 21 citations

Transurethral resection of the prostate and metastatic prostate cancer

1991 • 20 citations

Identification of lymph node metastases by use of polymerase chain reaction (PCR) in melanoma patients

1996 • 20 citations

Detection of Human Papillomavirus Types 16 and 18 in Primary and in Metastatic Lesions of Cervical Carcinomas

1994 • 20 citations

Combined Detection of CD44 Isoforms by Exon-Specific RT-PCR and Immunohistochemistry in Primary Human Brain Tumors and Brain Metastases

1996 • 20 citations

The role of molecular techniques in the clinical management of leukemia: Lessons from the philadelphia chromosome

1992 • 20 citations

Rare association of human herpesvirus 6 DNA with human papillomavirus DNA in cervical smears of women with normal and abnormal cytologies

1996 • 19 citations

Use of the polymerase chain reaction to study the relationship between human papillomavirus infections and cervical cancer

1991 • 19 citations

Squamous cell carcinoma-associated antigens used in novel strategies for the detection and treatment of minimal residual head and neck cancer.

1996 • 19 citations

Detection of p53 tumor-suppressor-gene protein in bladder tumors and prostate cancer: possible clinical implications

1994 • 19 citations

The clinical significance of malfunction of the CD44 locus in malignancy

1995 • 18 citations

Molecular basis of human B cell neoplasia

1985 • 18 citations

Detection of early micrometastases in subcutaneous fat of primary malignant melanoma patients by identification of tyrosinase-mRNA

1996 • 18 citations

Detection of H-ras Gene Point Mutations in Transitional Cell Carcinoma of Human Urinary Bladder Using Polymerase Chain Reaction.

1992 • 18 citations

Pathology of malignant melanoma, including new markers and techniques in diagnosis and prognosis

1996 • 18 citations

Detection of Occult Tumour Cells in Bone Marrow and Blood in Breast Cancer Patients

1996 • 17 citations

Detection of K-ras Point Mutations in Mesenteric Venous Blood from Colorectal Cancer Patients by Enriched Polymerase Chain Reaction and Single-strand Conformation Polymorphism Analysis

1996 • 16 citations

Detection of cancer cells in peripheral blood stem cells of women with breast cancer by RT-PCR and cell culture.

1996 • 16 citations

Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures

1995 • 16 citations

Analysis of p53 tumor suppressor gene mutations and human papillomavirus infection in human bladder cancers

1995 • 16 citations

Detection of Human Papillomavirus Type 16 E6/E7 Transcripts in Histologically Cancer-Free Pelvic Lymph Nodes of Patients with Cervical Carcinoma

1994 • 15 citations

Human papillomavirus in genital carcinogenesis.

1994 • 14 citations

Immunomagnetic purification of human breast carcinoma cells allows tumor-specific detection of multidrug resistance gene 1-mRNA by reverse transcriptase polymerase chain reaction in fine-needle aspirates.

1995 • 14 citations

Greater frequency of K-ras Val-12 mutation in colorectal cancer as detected with sensitive methods

1996 • 13 citations

HPV types in women with normal cervical cytology.

1992 • 12 citations

Clinical significance of genetic rearrangements in human neuroblastomas.

1989 • 12 citations

Human papillomavirus DNA in invasive cervical carcinomas and its association with patient survival: a nested case-control study.

1996 • 12 citations

Loss of the putative tumor suppressor-gene locus 1p36 as investigated by a PCR-assay and N-myc amplification in 48 neuroblastomas: results of the German Neuroblastoma Study Group.

1994 • 11 citations

The polymerase chain reaction and cancer diagnostics

1992 • 11 citations

Analysis of tumor spillage during radical prostatectomy using RT-PCR of prostate specific antigen.

1996 • 11 citations

Isolation of DNA from Stool and Bodily Fluids for PCR Amplification

1996 • 10 citations

Expression of CD44 splice variants in bladder cancer.

1995 • 9 citations

The molecular staging of prostate cancer.

1995 • 9 citations

Comparison between immunocytochemical and polymerase chain reaction techniques for detection of oestrogen receptor and transforming growth factor β in breast cancer

1996 • 9 citations

The Role of Motility Proteins and Metastasis‐Suppressor Genes in Prostate Cancer Progression

1996 • 8 citations

EXPRESSION OF CD44 SPLICE VARIANTS IN BLADDER CANCER

1995 • 8 citations

Detection of human papillomavirus type 16 E6/E7 transcripts in fixed paraffin-embedded cervical cancers by the polymerase chain reaction

1991 • 8 citations

Detection of Minimal Residual Disease

1995 • 7 citations

The use of the polymerase chain reaction in clinical oncology.

1992 • 7 citations

Ha-ras oncogene (codon 12) mutation in thyroid carcinogenesis: analysis of 60 benign and malignant thyroid tumors.

1995 • 5 citations

Detection of DNA sequence polymorphisms in carcinogen metabolism genes by polymerase chain reaction

1991 • 4 citations

Double Determinant Immuno‐Polymerase Chain Reaction for Detecting Soluble Intercellular Adhesion Molecule‐1

1996 • 4 citations

Application of the polymerase chain reaction for detection of minimal residual disease of hematologic malignancies.

1991 • 3 citations

Deleted Work

1955 • 0 citations