Microsatellite alterations as clonal markers for the detection of human cancer.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

A second-generation linkage map of the human genome

1992 • 1,721 citations

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1

1993 • 1,596 citations

Mutation of human short tandem repeats

1993 • 1,584 citations

Cancer statistics, 1994

1994 • 1,345 citations

Unstable expansion of CAG repeat in hereditary dentatorubral–pallidoluysian atrophy (DRPLA)

1994 • 1,122 citations

Mapping of DNA Instability at the Fragile X to a Trinucleotide Repeat Sequence P(CCG) n

1991 • 903 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors

1992 • 703 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Clonal origin of human tumors

1976 • 662 citations

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

1993 • 596 citations

Clonal Origin of Bladder Cancer

1992 • 538 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I

1993 • 473 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm

1994 • 415 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

Detection of oncogene mutations in sputum precedes diagnosis of lung cancer

1994 • 403 citations

Allelotype of head and neck squamous cell carcinoma.

1994 • 349 citations

Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.

1994 • 322 citations

Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction.

1992 • 253 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

Origin of the expansion mutation in myotonic dystrophy

1993 • 213 citations

Microsatellite instability in bladder cancer.

1993 • 187 citations

Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction.

1994 • 164 citations

Evidence for two bladder cancer suppressor loci on human chromosome 9.

1993 • 143 citations

Molecular Predictors of Cognitive Involvement in Female Carriers of Fragile X Syndrome

1994 • 143 citations

Moderate instability of the trinucleotide repeat in spino bulbar muscular atrophy

1992 • 125 citations

Analysis of somatic mutations at human minisatellite loci in tumors and cell lines

1989 • 98 citations

Molecular Biology and the Early Detection of Carcinoma of the Bladder -- The Case of Hubert H. Humphrey

1994 • 67 citations

p53 Gene Mutations as Markers of Tumor Spread in Synchronous Oral Cancers

1994 • 53 citations