Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Avoiding false positives with PCR

1989 • 3,564 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage

1977 • 888 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

1983 • 743 citations

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

1988 • 741 citations

Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor δ Chain

1989 • 640 citations

Marrow Transplantation for the Treatment of Chronic Myelogenous Leukemia

1986 • 566 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Bone Marrow Transplantation for Patients with Chronic Myeloid Leukemia

1986 • 422 citations

Evaluation of Response-Time Data Involving Transient States: An Illustration Using Heart-Transplant Data

1974 • 417 citations

Interferon-Alpha Produces Sustained Cytogenetic Responses in Chronic Myelogenous Leukemia

1991 • 398 citations

All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment

1991 • 347 citations

Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease.

1988 • 341 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

Detection of residual leukemia after bone marrow transplant for chronic myeloid leukemia: role of polymerase chain reaction in predicting relapse

1991 • 265 citations

Involvement of the B-lymphoid system in chronic myelogenous leukaemia

1980 • 240 citations

Detection of minimal residual disease in acute lymphoblastic leukemia by in vitro amplification of rearranged T-cell receptor delta chain sequences

1989 • 200 citations

Results of treatment of Ph'+ chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol)

1979 • 194 citations

Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia

1989 • 183 citations

The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.

1987 • 179 citations

POLYMERASE CHAIN REACTION FOR DETECTION OF RESIDUAL LEUKAEMIA

1989 • 152 citations

Indications for marrow transplantation in chronic myelogenous leukemia [see comments]

1989 • 151 citations

Prognostic significance of Philadelphia chromosome-positive cells detected by the polymerase chain reaction after allogeneic bone marrow transplant for chronic myelogenous leukemia

1992 • 145 citations

Molecular relapse in chronic myelogenous leukemia patients after bone marrow transplantation detected by polymerase chain reaction.

1990 • 137 citations

Specific Synthesis of DNA in Vitro via a Polymerase-Catalyzed Chain Reaction

1989 • 133 citations

Detection of occult follicular lymphoma by specific DNA amplification

1988 • 116 citations

Origin of Chronic Myelocytic Leukemia in a Precursor of Pre-B Lymphocytes

1979 • 113 citations

Intensive combination chemotherapy (ROAP 10) and splenectomy in the management of chronic myelogenous leukemia.

1985 • 111 citations

Cytogenetic Studies in Acute Myelocytic Leukemia with Special Emphasis on the Occurrence of Ph1 Chromosome

1970 • 110 citations

Detection of minimal residual bcr/abl transcripts by a modified polymerase chain reaction

1988 • 109 citations

A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia

1992 • 107 citations

Cytogenetic events after bone marrow transplantation for chronic myeloid leukemia in chronic phase

1988 • 107 citations

DETECTION OF RESIDUAL bcr/abl TRANSLOCATION BY POLYMERASE CHAIN REACTION IN CHRONIC MYELOID LEUKAEMIA PATIENTS AFTER BONE-MARROW TRANSPLANTATION

1989 • 106 citations

Detection of minimal residual disease in chronic myeloid leukemia patients after bone marrow transplantation by polymerase chain reaction.

1990 • 99 citations

Molecular quantification of residual disease in chronic myelogenous leukemia after bone marrow transplantation

1992 • 97 citations

Frequent detection of minimal residual disease by use of the polymerase chain reaction in long-term survivors after bone marrow transplantation for chronic myeloid leukemia.

1990 • 89 citations

Detection of the molecular abnormality in chronic myeloid leukemia by use of the polymerase chain reaction

1988 • 84 citations

Nonhomogeneous distribution of leukemia in the bone marrow during minimal residual disease

1987 • 78 citations

HLA-identical marrow transplantation during accelerated-phase chronic myelogenous leukemia: analysis of survival and remission duration

1988 • 78 citations

Detection by enzymatic amplification of bcr-abl mRNA in peripheral blood and bone marrow cells of patients with chronic myelogenous leukemia

1989 • 72 citations

Detection of residual BCR/ABL transcripts in chronic myeloid leukaemia patients in complete remission using the polymerase chain reaction and nested primers

1990 • 70 citations

Minimal residual disease in patients with chronic myelogenous leukemia undergoing long-term treatment with recombinant interferon alpha-2b alone or in combination with interferon gamma

1991 • 63 citations

Clonal analysis of bcr-abl rearrangement in T lymphocytes from patients with chronic myelogenous leukemia

1992 • 53 citations

Report from the International Bone Marrow Transplant Registry, 1984.

1985 • 51 citations

T lymphocytes lack rearrangement of the bcr gene in Philadelphia chromosome-positive chronic myelocytic leukemia

1987 • 48 citations

POLYMERASE CHAIN REACTION FOR DETECTION OF DISSEMINATION IN GASTRIC LYMPHOMA

1989 • 45 citations

Characterization of bcr gene products in hematopoietic cells.

1989 • 40 citations

The emerging genetics of acute lymphoblastic leukemia: clinical and biologic implications.

1985 • 31 citations

Relapse after allogeneic bone marrow transplantation for Philadelphia chromosome positive chronic myeloid leukemia: cytogenetic analysis of 24 patients.

1988 • 28 citations

Philadelphia‐positive metaphases in the marrow after bone marrow transplantation for chronic granulocytic leukemia

1986 • 28 citations

Chromosome studies in patients with Philadelphia chromosome-positive chronic myeloid leukemia submitted to bone marrow transplantation—Results of a European cooperative study

1987 • 27 citations

Biological importance of residual leukaemic cells after BMT for CML: does the polymerase chain reaction help?

1990 • 25 citations

bcr/abl mRNA DETECTION FOLLOWING BONE MARROW TRANSPLANTATION FOR CHRONIC MYELOGENOUS LEUKEMIA

1991 • 21 citations

The Evolving Role of Bone Marrow Transplantation in the Treatment of Chronic Myelogenous Leukemia

1990 • 11 citations

Differential effects of tumor promoters on P210bcr-abl expression.

1989 • 5 citations

Bone marrow transplantation for the treatment of chronic myelogenous leukemia.

1990 • 3 citations