Investigating Stem Cells in the Lung

Cancer Cell Cycles

1996 • 5,379 citations

‘Green mice’ as a source of ubiquitous green cells

1997 • 2,586 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

1990 • 1,793 citations

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

1996 • 1,208 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain

1991 • 882 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

1996 • 779 citations

The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen.

1974 • 698 citations

Transformation of alveolar Type 2 cells to Type 1 cells following exposure to NO2

1975 • 577 citations

Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.

1990 • 545 citations

Stem cells: the generation and maintenance of cellular diversity

1989 • 504 citations

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

1987 • 472 citations

Renewal of alveolar epithelium in the rat following exposure to NO2.

1973 • 429 citations

Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

1987 • 396 citations

Hepatocyte Nuclear Factor 3/fork head Homolog 11 Is Expressed in Proliferating Epithelial and Mesenchymal Cells of Embryonic and Adult Tissues

1997 • 359 citations

Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice.

1993 • 338 citations

Molecular Analysis of the Short Arm of Chromosome 3 in Small-Cell and Non-Small-Cell Carcinoma of the Lung

1987 • 331 citations

Derivation of mouse intestinal crypts from single progenitor cells

1985 • 330 citations

Hepatic stem cells in liver regeneration

1996 • 308 citations

Role of the Clara cell in renewal of the bronchiolar epithelium.

1978 • 303 citations

Drosophila NK-homeobox genes.

1989 • 300 citations

Transcriptional Elements from the Human SP-C Gene Direct Expression in the Primordial Respiratory Epithelium of Transgenic Mice

1993 • 299 citations

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.

1996 • 294 citations

Renewal of the terminal bronchiolar epithelium in the rat following exposure to NO2 or O3.

1976 • 289 citations

Non-injection methods for the production of embryonic stem cell-embryo chimaeras

1993 • 286 citations

Differentiation requires continuous regulation.

1991 • 276 citations

Lung Development in the Mouse Embryo

1991 • 269 citations

A clonal marker induced by mutation in mouse intestinal epithelium

1988 • 255 citations

Gastrin-Releasing Peptide (Mammalian Bombesin) Gene Expression in Health and Disease

1989 • 251 citations

Derivation of type 1 epithelium from type 2 cells in the developing rat lung.

1975 • 241 citations

Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine

1988 • 235 citations

Ligand-inducible and liver-specific target gene expression in transgenic mice

1997 • 234 citations

Growth and Differentiation in the Hemopoietic System

1987 • 220 citations

Mutations in the p16(INK4)/MTS1/CDKN2, p15(INK4B)/MTS2, and p18 genes in primary and metastatic lung cancer

1995 • 208 citations

Plasticity of airway cell proliferation and gene expression after acute naphthalene injury

1995 • 200 citations

Reversible transdifferentiation of alveolar epithelial cells.

1995 • 191 citations

Induction of Alveolar Type II Cell Differentiation in Fetal Tracheal Epithelium by Grafted Distal Lung Mesenchyme

1994 • 191 citations

Cytochrome P-450: Localization in Rabbit Lung

1980 • 179 citations

Demonstration of somatic mutation and colonic crypt clonality by X-linked enzyme histochemistry

1988 • 170 citations

Branching morphogenesis of embryonic mouse lung epithelium in mesenchyme-free culture

1995 • 167 citations

TTF-1 Regulates Lung Epithelial Morphogenesis

1995 • 164 citations

Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice

1995 • 163 citations

DIFFERENTIATION REQUIRES CONTINUOUS ACTIVE CONTROL

1992 • 158 citations

Cell Renewal in the Lungs of Rats Exposed to Low Levels of NO₂

1972 • 158 citations

Field cancerization in the aerodigestive tract--its etiology, manifestation, and significance.

1984 • 157 citations

Bombesin Increases Fetal Lung Growth and Maturation In Utero and in Organ Culture

1990 • 153 citations

Potent inhibition of both human interferon-gamma production and biologic activity by the Clara cell protein CC16.

1995 • 147 citations

Comparison of Nonciliated Tracheal Epithelial Cells in Six Mammalian Species: Ultrastructure and Population Densities

1983 • 145 citations

Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy.

1984 • 139 citations

Hepatocyte Nuclear Factor 3 Activates Transcription of Thyroid Transcription Factor 1 in Respiratory Epithelial Cells

1996 • 139 citations

Effects of vitamin A-deprivation on hamster tracheal epithelium

1984 • 139 citations

Members of the HNF-3/forkhead Family of Transcription Factors Exhibit Distinct Cellular Expression Patterns in Lung and Regulate the Surfactant Protein B Promoter

1994 • 133 citations

The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families.

1993 • 126 citations

Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.

1993 • 126 citations

Upstream Enhancer Activity in the Human Surfactant Protein B Gene Is Mediated by Thyroid Transcription Factor 1

1995 • 126 citations

Pulmonary small cell carcinoma showing tripartite differentiation in individual cells

1981 • 121 citations

Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice.

1992 • 120 citations

Morphology of a naphthalene-induced bronchiolar lesion.

1977 • 115 citations

Ozone-induced Acute Tracheobronchial Epithelial Injury: Relationship to Granulocyte Emigration in the Lung

1992 • 115 citations

Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung.

1992 • 107 citations

Clara cell 10 kDa protein (CC10): Comparison of structure and function to uterogloblin

1990 • 106 citations

The Lung-Specific Surfactant Protein B Gene Promoter Is a Target for Thyroid Transcription Factor 1 and Hepatocyte Nuclear Factor 3, Indicating Common Factors for Organ-Specific Gene Expression along the Foregut Axis

1994 • 105 citations

Transcriptional Regulation of a Mouse Clara Cell-Specific Protein (mCC10) Gene by the NKx Transcription Factor Family Members Thyroid Transcription Factor 1 and Cardiac Muscle-Specific Homeobox Protein (CSX)

1996 • 101 citations

The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo

1997 • 97 citations

Nonrandom structural and numerical chromosome changes in non‐small‐cell lung cancer

1991 • 95 citations

Morphogenesis of the Lung: Control of Embryonic and Fetal Branching

1996 • 95 citations

Three distinct regions involved in 3P deletion in human lung cancer.

1993 • 92 citations

Growth and differentiation factors in tracheobronchial epithelium

1991 • 90 citations

Cell proliferation contributes to PNEC hyperplasia after acute airway injury

1997 • 90 citations

10T1/2 cells: an in vitro model for molecular genetic analysis of mesodermal determination and differentiation.

1989 • 86 citations

Cis-active elements controlling lung cell-specific expression of human pulmonary surfactant protein B gene

1993 • 84 citations

The Role of Basal Cells in Attachment of Columnar Cells to the Basal Lamina of the Trachea

1989 • 81 citations

Role of hepatocyte nuclear factor-3α and hepatocyte nuclear factor-3β in Clara cell secretory protein gene expression in the bronchiolar epithelium

1995 • 80 citations

Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma

1995 • 80 citations

Spectrum of lung cancer and ectopic hormones.

1978 • 76 citations

Proliferation and differentiation of fetal rat pulmonary epithelium in the absence of mesenchyme.

1995 • 69 citations

Two members of the HNF-3 family have opposite effects on a lung transcriptional element; HNF-3 alpha stimulates and HNF-3 beta inhibits activity of region I from the Clara cell secretory protein (CCSP) promoter.

1994 • 64 citations

Effect of low level of ozone on rat lungs

1978 • 64 citations

Hepatocyte nuclear factor-3 alpha promoter regulation involves recognition by cell-specific factors, thyroid transcription factor-1, and autoactivation.

1997 • 62 citations

Inhibition of pancreatic phospholipase A2 activity by uteroglobin and antiflammin peptides: Possible mechanism of action

1991 • 55 citations

Action of Phorbol Esters, Bryostatins, and Retinoic Acid on Cholesterol Sulfate Synthesis: Relation to the Multistep Process of Differentiation in Human Epidermal Keratinocytes

1989 • 55 citations

Neuroepithelial bodies stimulate proliferation of airway epithelium in fetal hamster lung

1991 • 55 citations

Alterations of CDKN2 (p16) in non‐small cell lung cancer

1995 • 52 citations

Immunocytochemical localization of aromatic L-amino acid decarboxylase in human, rat, and mouse bronchopulmonary and gastrointestinal endocrine cells.

1988 • 51 citations

Expression of SV40 T antigen under control of rabbit uteroglobin promoter in transgenic mice

1991 • 49 citations

Cloning and Characterization of the Mouse Clara Cell-Specific 10-kDa Protein Gene: Comparison of the 5′-Flanking Region with the Human, Rat, and Rabbit Gene

1993 • 48 citations

Molecular Genetic Changes Found in Human Lung Cancer and Its Precursor Lesions

1994 • 47 citations

Differentiated bronchiolar epithelium in alveolar ducts of rats exposed to ozone for 20 months.

1993 • 47 citations

Scanning electron microscopy of bronchiolar neuroepithelial bodies in neonatal mouse lungs

1979 • 45 citations

Cyclin-dependent kinase inhibitor expression in pulmonary Clara cells transformed with SV40 large T antigen in transgenic mice.

1997 • 45 citations

cis-Acting Elements Involved in the Regulation of Mouse Clara Cell-specific 10-kDa Protein Gene

1995 • 44 citations

Tumor progression and cellular differentiation of pulmonary adenocarcinomas in SV40 large T antigen transgenic mice.

1997 • 44 citations

Maintenance of differentiated murine Clara cells in microdissected airway cultures.

1996 • 41 citations

Immunohistochemical localization of mouse Clara cell 10-KD protein using antibodies raised against the recombinant protein.

1996 • 37 citations

Uteroglobin Messenger Ribonucleic Acid: Localization in Rabbit Uterus and Lung byin SituHybridization

1986 • 35 citations

Qualitative and quantitative changes in cytochrome p‐450‐dependent xenobiotic metabolism in pulmonary microsomes and isolated clara cell populations derived from ozone‐exposed rats

1988 • 32 citations

Purification and Level of Expression in Bronchoalveolar Lavage of a Human Polychlorinated Biphenyl (PCB)-binding Protein: Evidence for a Structural and Functional Kinship to the Multihormonally Regulated Protein Uteroglobin

1991 • 32 citations

Uteroglobin gene expression in the rabbit uterus throughout gestation and in the fetal lung. Relationship between uteroglobin and eicosanoid levels in the developing fetal lung.

1995 • 31 citations

Structure and function of the mouse surfactant protein B gene

1995 • 31 citations

Effect of gamma radiation at high- and low-dose rate on a novel in vivo mutation assay in mouse intestine

1989 • 30 citations

Expression and Regulation of the Rabbit Uteroglobin Gene in Transgenic Mice

1991 • 29 citations

Anchoring fibrils in the normal canine respiratory system.

1979 • 29 citations

Pulmonary cytochrome P-450 monooxygenase system and Clara cell differentiation in rats

1995 • 29 citations

Somatic genetic changes in lung cancer and precancerous lesions

1995 • 29 citations

Quantitative characteristics of the Feyrter cells and neuroepithelial bodies of the fetal rabbit lung in normoxia and short term chronic hypoxia

1978 • 29 citations

Bioactivation of 3-methylindole by isolated rabbit lung cells

1990 • 28 citations

The Mechanisms and Control of Bronchial Mucous Cell Hyperplasia

1982 • 26 citations

A Comprehensive Ultrastructural Study of Pulmonary Injury and Repair in the Rat Resulting From Exposures to Less Than One PPM Ozone

1974 • 23 citations

Clara cell heterogeneity in differentiation: correlation with proliferation, ultrastructural composition, and cell position in the rat bronchiole.

1995 • 22 citations

The hormonal regulation of uteroglobin gene expression.

1985 • 14 citations

Calcium‐dependent binding of uteroglobin (PCB‐BP/CCSP) to negatively charged phospholipid liposomes

1995 • 12 citations

Lung pathology: the molecular genetics of non-small cell lung cancer

1995 • 8 citations

Bombesin May Play a Role in Fetal Lung Growth and Maturation in Utero and in Lung Organ Culture

1991 • 3 citations

A transgenic mouse model for lung adenocarcinoma

1997 • 1 citations