Hepatocyte nuclear factor-3 alpha promoter regulation involves recognition by cell-specific factors, thyroid transcription factor-1, and autoactivation.

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

1996 • 1,208 citations

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

1990 • 1,044 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Sp1-mediated transcriptional activation is repressed by Sp3.

1994 • 692 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite

1989 • 661 citations

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

1994 • 651 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

1993 • 619 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

Transcriptional control in the production of liver-specific mRNAs

1981 • 593 citations

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

1995 • 569 citations

Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.

1990 • 545 citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

1989 • 545 citations

The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis.

1994 • 518 citations

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

1991 • 517 citations

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

1993 • 505 citations

Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.

1996 • 493 citations

The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain

1989 • 490 citations

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.

1990 • 466 citations

DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally

1990 • 410 citations

Regulation of the Apolipoprotein AI Gene by ARP-1, a Novel Member of the Steroid Receptor Superfamily

1991 • 382 citations

Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst.

1994 • 372 citations

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.

1994 • 357 citations

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

1993 • 336 citations

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.

1996 • 294 citations

Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia

1992 • 290 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium.

1994 • 270 citations

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.

1990 • 264 citations

TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins.

1991 • 246 citations

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.

1992 • 234 citations

Enzymic Differentiation in Mammalian Liver

1969 • 213 citations

The HNF-3 Gene Family of Transcription Factors in Mice: Gene Structure, cDNA Sequence, and mRNA Distribution

1994 • 204 citations

Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein.

1992 • 188 citations

Expression of vasopressin V1a and V2 receptor messenger ribonucleic acid in the liver and kidney of embryonic, developing, and adult rats.

1993 • 146 citations

The Transcriptional Activator Hepatocyte Nuclear Factor 6 Regulates Liver Gene Expression

1996 • 144 citations

Hepatocyte Nuclear Factor 3 Activates Transcription of Thyroid Transcription Factor 1 in Respiratory Epithelial Cells

1996 • 139 citations

Members of the HNF-3/forkhead Family of Transcription Factors Exhibit Distinct Cellular Expression Patterns in Lung and Regulate the Surfactant Protein B Promoter

1994 • 133 citations

Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis

1993 • 127 citations

The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families.

1993 • 126 citations

Upstream Enhancer Activity in the Human Surfactant Protein B Gene Is Mediated by Thyroid Transcription Factor 1

1995 • 126 citations

Use of transgenic mice to map cis-acting elements in the liver fatty acid-binding protein gene (Fabpl) that regulate its cell lineage-specific, differentiation-dependent, and spatial patterns of expression in the gut epithelium and in the liver acinus.

1993 • 124 citations

Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium.

1995 • 120 citations

Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization.

1995 • 99 citations

The Restricted Promoter Activity of the Liver Transcription Factor Hepatocyte Nuclear Factor 3β Involves a Cell-Specific Factor and Positive Autoactivation

1992 • 98 citations

Comparative distribution of carbonic anhydrase isozymes III and II in rodent tissues

1990 • 95 citations

Decreased Expression of Hepatocyte Nuclear Factor 3α during the Acute-Phase Response Influences Transthyretin Gene Transcription

1995 • 95 citations

Tissue-Specific Regulation of Mouse Hepatocyte Nuclear Factor 4 Expression

1994 • 95 citations

Sucrase-isomaltase gene expression along crypt-villus axis of human small intestine is regulated at level of mRNA abundance

1992 • 89 citations

Chicken vitellogenin gene-binding protein, a leucine zipper transcription factor that binds to an important control element in the chicken vitellogenin II promoter, is related to rat DBP.

1991 • 89 citations

The hepatocyte nuclear factor-3/forkhead transcription regulatory family in development, inflammation, and neoplasia

1995 • 86 citations

E-cadherin expression in intestinal epithelium.

1995 • 85 citations

The DNA Binding Activity and the Dimerization Ability of the Thyroid Transcription Factor I Are Redox Regulated

1995 • 80 citations

Restriction of lactase gene expression along the proximal-to-distal axis of rat small intestine occurs during postnatal development

1994 • 58 citations

Retinoic acid-mediated activation of HNF-3α during EC stem cell differentiation

1994 • 49 citations

Overproduction of a Truncated Hepatocyte Nuclear Factor 3 Protein Inhibits Expression of Liver-Specific Genes in Hepatoma Cells

1995 • 48 citations

Loss of human E-cadherin (ECD) correlated with invasiveness of transitional cell cancer in the renal pelvis, ureter and urinary bladder

1996 • 48 citations

Temporal and spatial patterns of transgene expression in aging adult mice provide insights about the origins, organization, and differentiation of the intestinal epithelium.

1991 • 47 citations

Platelet-derived growth factor A-chain expression in developing and mature human kidneys and in Wilms' tumor

1995 • 46 citations

Expression and different polarity of aminopeptidase N in normal human colonic mucosa and colonic tumors

1992 • 27 citations

Nucleotide sequence of the bovine interleukin-6Genepromoter

1992 • 18 citations

Delayed Activation of HNF-3β upon Retinoic Acid-Induced Teratocarcinoma Cell Differentiation

1994 • 17 citations

Molecular cloning and characterization of the promoter region of the calcineurin Aα gene

1992 • 11 citations