Bioactivation of 3-methylindole by isolated rabbit lung cells

Methods in Enzymology , Vol

1966 • 26,261 citations

In vitro methods in cell-mediated and tumor immunity

1976 • 1,266 citations

Tissue Culture. Methods and Applications

1974 • 1,068 citations

An improved method for isolating type II cells in high yield and purity.

1986 • 606 citations

The type II epithelial cell of the lung. I. Method of isolation.

1974 • 313 citations

Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct

1981 • 206 citations

Toxicants of Plant Origin

2023 • 172 citations

Induction of Pulmonary Edema and Emphysema in Cattle and Goats with 3-Methylindole

1972 • 150 citations

Fecal skatole and indole and breath methane and hydrogen in patients with large bowel polyps or cancer

1985 • 119 citations

Reactive intermediates. Part I. Synthesis and oxidation of 1- and 2-aminobenzotriazole

1969 • 102 citations

Xenobiotic metabolism by isolated pulmonary cells

1989 • 102 citations

Mechanisms of 3-methylindole pneumotoxicity

1989 • 85 citations

Role of mixed-function oxidase in 3-methylindole-induced acute pulmonary edema in goats.

1979 • 74 citations

The cytochrome P-450 monooxygenase system of rabbit lung enzyme components, activities, and induction in the nonciliated bronchiolar epithelial (Clara) cell, alveolar type II cell, and alveolar macrophage.

1986 • 72 citations

In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT)

1988 • 71 citations

In vitro metabolic activation of the pulmonary toxin, 4-ipomeanol, in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung.

1982 • 69 citations

[17] Isolation of pulmonary cells and use in studies of xenobiotic metabolism

1981 • 55 citations

Structure of the glutathione adduct of activated 3-methylindole indicates that an imine methide is the electrophilic intermediate.

1985 • 55 citations

Quantitative determination of 1-alkylindoles in cigarette smoke

1970 • 48 citations

Inhibition of 3-methylindole bioactivation by the cytochrome P-450 suicide substrates 1-aminobenzotriazole and alpha-methylbenzylaminobenzotriazole.

1989 • 46 citations

Mechanisms of lung injury by systemically administered chemicals

1989 • 45 citations

Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole.

1985 • 43 citations

3-Methylindole and naturally occurring acute bovine pulmonary edema and emphysema.

1979 • 42 citations

N-alkylaminobenzotriazoles as isozyme-selective suicide inhibitors of rabbit pulmonary microsomal cytochrome P-450.

1986 • 41 citations

Pathologic changes in 3-methylindole-induced equine bronchiolitis.

1983 • 36 citations

Effect of glutathione status on covalent binding and pneumotoxicity of 3-methylindole in goats

1983 • 34 citations

Pyrrolooxygenases: Isolation, properties, and products formed

1972 • 31 citations

Adducts of 3-methylindole and glutathione: Species differences in organ-selective bioactivation

1985 • 29 citations

Decreased pneumotoxicity of deuterated 3-methylindole: Bioactivation requires methyl CH bond breakage

1987 • 28 citations

Dose response in 3-methylindole-induced bronchiolar epithelial necrosis in mice.

1984 • 25 citations

Organ-selective switching of 3-methylindole toxicity by glutathione depletion

1990 • 20 citations

6-Sulphatoxyskatole in human urine

1961 • 20 citations

Isolation and identification of 3-hydroxy-3-methyloxindole, the major murine metabolite of 3-methylindole

1989 • 19 citations

Pathology and glutathione status in 3-methylindole-treated rodents.

1988 • 19 citations

Autoradiographic evidence of 3-methylindole covalent binding to pulmonary epithelial cells in the goat

1984 • 16 citations

Concentration of 3-Methylindole (3MI) and distribution of radioactivity from 14C3MI in goat tissues associated with acute pulmonary edema

1982 • 16 citations

Detection of 3-hydroxy-3-methyloxindole in human urine

1989 • 11 citations

[13] Use of artificial electron acceptors in the study of dehydrogenases

1957 • 9 citations