Tumor Radiosensitivity and Apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Apoptotic Pathways

1998 • 1,193 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

Bcl-2 family proteins

1998 • 1,055 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

1998 • 752 citations

Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer.

1998 • 720 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy

1981 • 530 citations

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

1998 • 496 citations

Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L

1998 • 472 citations

Autoproteolytic Activation of Pro-Caspases by Oligomerization

1998 • 424 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Ultraviolet Radiation-induced Apoptosis Is Mediated by Activation of CD-95 (Fas/APO-1)

1997 • 298 citations

Expression and Regulation of Bcl-2, Bcl-xl, and Bax Correlate With p53 Status and Sensitivity to Apoptosis in Childhood Acute Lymphoblastic Leukemia

1997 • 212 citations

Heterogeneity in the Development of Apoptosis in Irradiated Murine Tumours of Different Histologies

1993 • 203 citations

Cytochrome c-dependent and -independent Induction of Apoptosis in Multiple Myeloma Cells

1997 • 200 citations

Ceramide in apoptosis—does it really matter?

1998 • 189 citations

Effect of Antisense c- raf -1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma

1989 • 189 citations

Radiation Biochemistry

1971 • 189 citations

Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions

1997 • 189 citations

Involvement of Cellular Proteolytic Machinery in Apoptosis

1997 • 184 citations

Oncogene-dependent apoptosis is mediated by caspase-9

1998 • 174 citations

Loss of ceramide production confers resistance to radiation-induced apoptosis.

1997 • 162 citations

The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation

1994 • 152 citations

Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma

1995 • 152 citations

Up-regulation of Fas (CD95) in human p53wild-type cancer cells treated with ionizing radiation

1997 • 128 citations

Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling.

1997 • 126 citations

Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1

1998 • 123 citations

Potential molecular targets for manipulating the radiation response

1997 • 119 citations

Astro research fellowship: Apoptosis as a predictor of tumor response to radiation in Stage IB cervical carcinoma

1995 • 114 citations

Apoptosis — Molecular mechanisms and biomedical implications

1996 • 113 citations

Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines.

1998 • 101 citations

Radiation-Induced Apoptosis in Human Lymphocytes and Lymphoma Cells Critically Relies on the Up-Regulation of CD95/Fas/APO-1 Ligand

1998 • 92 citations

Fas/Fas Ligand Interactions Are Involved in Ultraviolet-B-Induced Human Lymphocyte Apoptosis

1998 • 91 citations

Apoptosis: an indicator of radiosensitivity in vitro ?

1997 • 91 citations

p53 is involved in but not required for ionizing radiation-induced caspase-3 activation and apoptosis in human lymphoblast cell lines.

1998 • 85 citations

Bax and Bcl-2 expressions predict response to radiotherapy in human cervical cancer

1998 • 84 citations

Role of Ultraviolet A-Induced Oxidative DNA Damage in Apoptosis via Loss of Mitochondrial Membrane Potential and Caspase-3 Activation

1998 • 75 citations

Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24)

1996 • 70 citations

Blood Cells With Reduced Mitochondrial Membrane Potential and Cytosolic Cytochrome C Can Survive and Maintain Clonogenicity Given Appropriate Signals to Suppress Apoptosis

1998 • 61 citations

Bax protein expression correlates with radiation-induced apoptosis in radiation therapy for cervical carcinoma

1998 • 46 citations

Higher spontaneous apoptotic index in small cell compared with non-small cell lung carcinoma cell lines; lack of correlation with Bcl-2/Bax

1998 • 45 citations

p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation

1998 • 44 citations

Expression of P53, P21/WAF/CIP, BCL-2, BAX, BCL-X, and BAK In Radiation-Induced Apoptosis in Testicular Germ Cell Tumor Lines

1998 • 41 citations

Spontaneous and radiation-induced apoptosis in lung carcinoma cells with different intrinsic radiosensitivities.

1998 • 34 citations

Overexpression ofbax enhances the radiation sensitivity in human breast cancer cells

1997 • 33 citations

Interleukin-1β-Converting Enzyme and CPP32 Are Involved in Ultraviolet B-Induced Apoptosis of SV40-Transformed Human Keratinocytes

1997 • 32 citations

C-raf-1 proto-oncogene expression relates to radiosensitivity rather than radioresistance

1994 • 30 citations

p53-independent response of a human breast carcinoma xenograft to radioimmunotherapy

1997 • 26 citations

Involvement of ICE (Caspase) Family in γ‐Radiation‐Induced Apoptosis of Normal B Lymphocytes

1997 • 24 citations

Radiation-induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells

1997 • 24 citations

Role of P53 Mutations in the Radiosensitivity Status of Tumor Cells

1998 • 20 citations

Radiosensitivity of small‐cell lung cancer xenografts compared with activity of c‐myc, N‐myc, L‐myc, c‐raf‐1 and K‐ras proto‐oncogenes

1991 • 16 citations

Dominant oncogenes, tumor suppressors, and radiosensitivity.

1995 • 14 citations

The morphological and spectral phenotype of apoptosis in HeLa cells varies following exposure to UV‐C and the addition of inhibitors of ICE and CPP32

1998 • 9 citations

Response to radiotherapy of human uterine cervix carcinoma is not correlated with rearrangements of the HA-ras-1 and/or c-myc genes

1997 • 6 citations