Higher spontaneous apoptotic index in small cell compared with non-small cell lung carcinoma cell lines; lack of correlation with Bcl-2/Bax

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1972 • 15,349 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

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1993 • 684 citations

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A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome

1992 • 523 citations

Internucleosomal DNA Cleavage Should not be the Sole Criterion for Identifying Apoptosis

1992 • 462 citations

Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

1990 • 447 citations

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.

1993 • 419 citations

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Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

1997 • 221 citations

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors

1993 • 207 citations

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Small cell carcinomas of the lung express the Bcl-2 protein.

1994 • 163 citations

Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response

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Radiation sensitivity of human lung cancer cell lines

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Astro research fellowship: Apoptosis as a predictor of tumor response to radiation in Stage IB cervical carcinoma

1995 • 114 citations

Apoptosis — Molecular mechanisms and biomedical implications

1996 • 113 citations

Importance of the Bcl-2 family in cell death regulation

1996 • 107 citations

Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene.

1986 • 105 citations

Incidence of apoptosis and cell proliferation in prostate cancer: Relationship with TGF-β1 and bcl-2 expression

1996 • 104 citations

ESTABLISHMENT AND CHARACTERIZATION OF CELL LINES FROM HUMAN SMALL CELL AND LARGE CELL CARCINOMAS OF THE LUNG

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Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation

1994 • 96 citations

Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance

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Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity

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Preparation of cell nuclei from fresh tissues for high‐quality DNA flow cytometry

1993 • 67 citations

Two in situ labeling techniques reveal different patterns of DNA fragmentation during spontaneous apoptosis in vivo and induced apoptosis in vitro.

1995 • 62 citations

Apoptosis and mitosis as prognostic factors in pathologically staged N1 nonsmall cell lung cancer

1996 • 60 citations

Proteases in apoptosis

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1982 • 51 citations

Apoptosis in operated small cell lung carcinoma is inversely related to tumour necrosis and p53 immunoreactivity

1997 • 50 citations

Spontaneous and radiation-induced apoptosis in lung carcinoma cells with different intrinsic radiosensitivities.

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Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death

1995 • 33 citations

Single-Dose and Fractionated Irradiation of FouR Human Lung Cancer Cell Lines in Vitro

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Reduced expression of the ICE-related protease CPP32 is associated with radiation-induced cisplatin resistance in HeLa cells

1997 • 16 citations

Increased radioresistance of an in vitro transformed human small cell lung cancer cell line

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Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms

1997 • 13 citations

Characterisation of the G1/S cell cycle checkpoint defect in lung carcinoma cells with different intrinsic radiosensitivities.

1997 • 6 citations

667 Relation of Bax and Bcl2 with apoptosis and grade in neuroendocrine (NE) lung tumors other than small cell lung carcinoma

1997 • 1 citations