Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L

Apoptosis by Death Factor

1997 • 5,038 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Molecular basis of sun-induced premature skin ageing and retinoid antagonism

1996 • 1,379 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Apoptosis

1993 • 972 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

An evaluation of confocal versus conventional imaging of biological structures by fluorescence light microscopy.

1987 • 850 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.

1990 • 707 citations

Apoptosis and disease

1993 • 684 citations

Fas ligand in human serum

1996 • 682 citations

Frequent clones of p53-mutated keratinocytes in normal human skin

1996 • 678 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Kinetics of Response in Lymphoid Tissues to Antiretroviral Therapy of HIV-1 Infection

1997 • 631 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

The Role of Sunlight and DNA Repair in Melanoma and Nonmelanoma Skin Cancer

1994 • 524 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

p53 Mutations in human immortalized epithelial cell lines

1993 • 441 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

Confocal scanning light microscopy with high aperture immersion lenses

1979 • 410 citations

Sunlight and skin cancer: Another link revealed

1997 • 405 citations

Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.

1996 • 394 citations

FLICE Induced Apoptosis in a Cell-free System

1997 • 343 citations

Ultraviolet-B-Induced Apoptosis of Keratinocytes: Evidence for Partial Involvement of Tumor Necrosis Factor-α in the Formation of Sunburn Cells

1995 • 272 citations

Apoptosis and Its Role in Human Disease

1994 • 232 citations

Signals and signs in the nervous system: The dynamic anatomy of electrical activity is probably information-rich

1997 • 223 citations

Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation.

1993 • 195 citations

Fas/Fas Ligand Interaction Contributes to UV-Induced Apoptosis in Human Keratinocytes

1997 • 183 citations

Expression of Fas Antigen on Keratinocytes In Vivo and Induction of Apoptosis in Cultured Keratinocytes

1994 • 175 citations

The sunburn cell.

1987 • 170 citations

UVB Light Induces Nuclear Factor κB (NFκB) Activity Independently from Chromosomal DNA Damage in Cell-Free Cytosolic Extracts

1994 • 165 citations

Ultraviolet B Irradiation of Human Leukaemia HL-60 Cellsin VitroInduces Apoptosis

1991 • 158 citations

The Fas receptor in HIV infection

1996 • 126 citations

Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer

1994 • 111 citations

SUNBURN CELL: FACTORS INVOLVED IN ITS FORMATION.

1987 • 98 citations

Two Pathways for Induction of Apoptosis by Ultraviolet Radiation in Cultured Human Keratinocytes

1997 • 92 citations

Phenotypic and Genotypic Characteristics of a Cell Line From a Squamous Cell Carcinoma of Human Skin<xref ref-type="fn" rid="fn2">2</xref>

1982 • 90 citations

1,25-Dihydroxyvitamin D3, Transforming Growth Factor β1, Calcium, and Ultraviolet B Radiation Induce Apoptosis in Cultured Human Keratinocytes

1997 • 86 citations

PHOTOBIOLOGY SCHOOL

1990 • 72 citations

Keratinocytes constitutively express the Fas antigen that mediates apoptosis in IFN?-treated cultured keratinocytes

1995 • 71 citations

Identification of A 168-kDa Mucosal Antigen In A Subset of Patients With Cicatricial Pemphigoid

1996 • 69 citations

Interferon-γ-Dependent Stimulation of Fas Antigen in SV40-Transformed Human Keratinocytes: Modulation of the Apoptotic Process by Protein Kinase C

1995 • 50 citations

Actinic Injury

1990 • 38 citations

Neurodegeneration in Alzheimer disease

1996 • 37 citations

Role of ICE-related and other proteases in Fas-mediated apoptosis.

1996 • 17 citations