Vasoactive Intestinal Peptide and Pituitary Adenylyl Cyclase-Activating Polypeptide Inhibit Tumor Necrosis Factor-α Production in Injured Spinal Cord and in Activated Microglia via a cAMP-Dependent Pathway

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

Tumor necrosis factor-alpha expression in ischemic neurons.

1994 • 793 citations

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1993 • 789 citations

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

1988 • 771 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Production of tumor necrosis factor-alpha by microglia and astrocytes in culture

1989 • 626 citations

Macrophages and Inflammatory Mediators in Tissue Injury

1995 • 613 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

1999 • 552 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury

1999 • 413 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

Expression of Pro‐Inflammatory Cytokine and Chemokine mRNA Upon Experimental Spinal Cord Injury in Mouse: an In Situ Hybridization Study

1997 • 354 citations

Cytokine mRNA Profiles in Contused Spinal Cord and Axotomized Facial Nucleus Suggest a Beneficial Role for Inflammation and Gliosis

1998 • 347 citations

Closed Head Injury Triggers Early Production of TNFα and IL-6 by Brain Tissue

1994 • 344 citations

Elevated Cyclic AMP Inhibits NF-κB-mediated Transcription in Human Monocytic Cells and Endothelial Cells

1996 • 341 citations

Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription.

1997 • 320 citations

Oligodendrocyte Apoptosis and Primary Demyelination Induced by Local TNF/p55TNF Receptor Signaling in the Central Nervous System of Transgenic Mice

1998 • 317 citations

Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes

1996 • 317 citations

Tumor Necrosis Factor Alpha-Induced Apoptosis in Human Neuronal Cells: Protection by the Antioxidant N-Acetylcysteine and the Genes bcl-2 and crmA

1995 • 300 citations

Inhibition of Tumor Necrosis Factor Alpha (TNFα) Activity in Rat Brain is Associated with Cerebroprotection after Closed Head Injury

1996 • 284 citations

Exacerbation of Damage and Altered NF-κB Activation in Mice Lacking Tumor Necrosis Factor Receptors after Traumatic Brain Injury

1999 • 271 citations

Tumor Necrosis Factor-Alpha Potentiates Glutamate Neurotoxicity in Human Fetal Brain Cell Cultures

1994 • 243 citations

Ceramide Protects Hippocampal Neurons Against Excitotoxic and Oxidative Insults, and Amyloid β‐Peptide Toxicity

1996 • 229 citations

Distribution and characterization of tumor necrosis factor‐α‐like immunoreactivity in the murine central nervous system

1993 • 218 citations

Effects of pro-inflammatory cytokines in experimental spinal cord injury

1997 • 201 citations

Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons

1986 • 199 citations

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Enhance IL-10 Production by Murine Macrophages: In Vitro and In Vivo Studies

1999 • 199 citations

In vitro production of IL-6, IL-1 beta, and tumor necrosis factor-alpha by human embryonic microglial and neural cells.

1993 • 195 citations

HIV-1 Tat Induces Neuronal Death via Tumor Necrosis Factor-α and Activation of Non-N-methyl-d-aspartate Receptors by a NFκB-Independent Mechanism

1998 • 177 citations

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Tumor Necrosis Factor α Transcriptional Activation by Regulating Nuclear Factor-kB and cAMP Response Element-binding Protein/c-Jun

1998 • 177 citations

Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activation Polypeptide (PACAP) Protect Mice from Lethal Endotoxemia Through the Inhibition of TNF-α and IL-6

1999 • 173 citations

Induction of Tumor Necrosis Factor-α in the Mouse Hippocampus following Transient Forebrain Ischemia

1997 • 167 citations

VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNγ synthesis by T cells

1999 • 162 citations

Characterization of a novel brain‐derived microglial cell line isolated from neonatal rat brain

2001 • 161 citations

Increase of interleukin-1β mRNA and protein in the spinal cord following experimental traumatic injury in the rat

1997 • 160 citations

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide modulate endotoxin-induced IL-6 production by murine peritoneal macrophages

1998 • 155 citations

Production of tumor necrosis factor in spinal cord following traumatic injury in rats

1996 • 153 citations

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Prevent Inducible Nitric Oxide Synthase Transcription in Macrophages by Inhibiting NF-κB and IFN Regulatory Factor 1 Activation

1999 • 149 citations

VIP and PACAP: very important in pain?

1999 • 142 citations

Brain injury and tumor necrosis factors induce calbindin D‐28K in astrocytes: Evidence for a cytoprotective response

1995 • 142 citations

ICE/CED‐3 Family Executes Oligodendrocyte Apoptosis by Tumor Necrosis Factor

1997 • 141 citations

Pituitary adenylate cyclase activating peptide expression in the rat dorsal root ganglia: Up-regulation after peripheral nerve injury

1996 • 134 citations

Glia Increase Degeneration of Hippocampal Neurons through Release of Tumor Necrosis Factor-α

1998 • 131 citations

Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-β1 (TGF-β1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia

1999 • 126 citations

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit Endotoxin-Induced TNF-α Production by Macrophages: In Vitro and In Vivo Studies

1999 • 123 citations

Phenotypic plasticity in adult sympathetic ganglia in vivo: effects of deafferentation and axotomy on the expression of vasoactive intestinal peptide

1993 • 122 citations

Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury

1994 • 120 citations

Tumor necrosis factor facilitates regeneration of injured central nervous system axons

1991 • 117 citations

PACAP Type I Receptor Activation Promotes Cerebellar Neuron Survival Through the cAMP/PKA Signaling Pathway

1997 • 110 citations

Inhibition of mouse T‐cell proliferation by CGRP and VIP: Effects of these neuropeptides on IL‐2 production and cAMP synthesis

1991 • 110 citations

Neurotrophic action of VIP on spinal cord cultures

1985 • 107 citations

Tumor necrosis factor alpha upregulates human microglial cell production of interleukin-10 in vitro

1995 • 103 citations

Tumor Necrosis Factor-Alpha Production by Human Fetal Microglial Cells: Regulation by Other Cytokines

1995 • 102 citations

Superactive lipophilic peptides discriminate multiple vasoactive intestinal peptide receptors.

1995 • 101 citations

Cellular Localization and Temporal Elevation of Tumor Necrosis Factor‐α, Interleukin‐1α, and Transforming Growth Factor‐β1 mRNA in Hippocampal Injury Response Induced by Trimethyltin

1998 • 90 citations

Tumor Necrosis Factor‐Induced Proliferation of Astrocytes from Mature Brain Is Associated with Down‐Regulation of Glial Fibrillary Acidic Protein mRNA

1991 • 89 citations

Human astrocyte production of tumour necrosis factor-α, interleukin-1β, and interleukin-6 following exposure to lipopolysaccharide endotoxin

1993 • 78 citations

Regulation of substance P is similar to that of vasoactive intestinal peptide after axotomy or explantation of the rat superior cervical ganglion

1993 • 76 citations

Expression of Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL-6) mRNA in Adult Human Astrocytes

1996 • 75 citations

Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin

1993 • 73 citations

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide-38 inhibit IL-10 production in murine T lymphocytes.

1996 • 71 citations

Axotomy-induced changes in pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP receptor gene expression in the adult rat facial motor nucleus

1999 • 65 citations

The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF‐α

1998 • 55 citations

Conditioned Medium from Activated Microglia Promotes Cholinergic Differentiation in the Basal Forebrainin Vitro

1996 • 52 citations

Reduction of lipopolysaccharide-induced neurotoxicity in mixed cortical neuron/glia cultures by femtomolar concentrations of pituitary adenylate cyclase-activating polypeptide

1999 • 50 citations

Pituitary adenylate cyclase-activating peptide (PACAP) and PACAP type 1 receptor expression in regenerating adult mouse and rat superior cervical ganglia in vitro

1997 • 45 citations

Modulation of human natural killer activity by vasoactive intestinal peptide (VIP) family. VIP, glucagon and GHRF specifically inhibit NK activity

1992 • 42 citations

The expression of tumor necrosis factor-α in the rat brain after fluid percussive injury

1997 • 40 citations

Nerve growth factor inhibits apoptosis induced by tumor necrosis factor in PC12 cells

1999 • 40 citations

Vasoactive intestinal peptide inhibits IL-4 production in murine T cells by a post-transcriptional mechanism.

1996 • 39 citations

Neuropeptide Regulation of Cytokine Expression: Effects of VIP and Ro 25–1553

1995 • 38 citations

Vasoactive intestinal peptide but not galanin promotes survival of neonatal rat sympathetic neurons and neurite outgrowth of PC12 cells

1995 • 35 citations

Target-dependent plasticity of galanin and vasoactive intestinal peptide in the rat superior cervical ganglion after nerve lesion and re-innervation

1996 • 30 citations

Inhibitory effect of vasoactive intestinal peptide (VIP) on phagocytosis in mouse peritoneal macrophages

1994 • 16 citations

Expression of Membrane-Bound and Soluble Cell Adhesion Molecules by Human Brain Microvessel Endothelial Cells

1999 • 14 citations