Elevated Cyclic AMP Inhibits NF-κB-mediated Transcription in Human Monocytic Cells and Endothelial Cells

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Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

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Regulation of the tissue factor gene

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1991 • 273 citations

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1994 • 266 citations

Aspirin Inhibits Nuclear Factor–κB Mobilization and Monocyte Adhesion in Stimulated Human Endothelial Cells

1995 • 260 citations

Regulation of endothelial cell coagulant properties

1989 • 255 citations

Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB

1992 • 250 citations

Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1

1989 • 247 citations

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells

1993 • 239 citations

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells

1993 • 222 citations

Transcriptional Regulation of Tissue Factor Expression in Human Endothelial Cells

1995 • 219 citations

RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.

1995 • 198 citations

Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP.

1989 • 196 citations

Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1.

1993 • 192 citations

A Striking Similarity in the Organization of the E-Selectin and Bate Interferon gene Promoters

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The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester.

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Transactivation Domain 2 (TA2) of p65 NF-κB

1995 • 161 citations

The Interferon-Inducible p202 Protein as a Modulator of Transcription: Inhibition of NF-κB, c-Fos, and c-Jun Activities

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Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide.

1991 • 143 citations

Gating by Cyclic AMP: Expanded Role for an Old Signaling Pathway

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Regulation of tumor necrosis factor expression in a macrophage-like cell line by lipopolysaccharide and cyclic AMP

1989 • 121 citations

Lipopolysaccharide Induction of Tissue Factor Gene Expression in Monocytic Cells Is Mediated by Binding of c-Rel/p65 Heterodimers to a κB-Like Site

1994 • 118 citations

Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells

1995 • 89 citations

Inhibition of E-selectin gene transcription through a cAMP-dependent protein kinase pathway.

1994 • 84 citations

cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 (E-selectin) promoter.

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cAMP-dependent phosphorylation and inactivation of yeast transcription factor ADR1 does not affect DNA binding.

1990 • 71 citations

Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers

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v-Rel and c-Rel are differentially affected by mutations at a consensus protein kinase recognition sequence.

1993 • 54 citations

The stable prostacyclin analog, iloprost, and prostaglandin E1 inhibit monocyte procoagulant activity in vitro

1991 • 49 citations

Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism

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Endotoxin-induced tissue factor messenger RNA in human monocytes is negatively regulated by a cyclic AMP-dependent mechanism

1993 • 40 citations

Pentoxifylline Inhibition of Procoagulant Activity Generated by Activated Mononuclear Phagocytes

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Cyclic AMP-Independent Activation of Transcription Factor NF-κB in HL60 Cells by Tumor Necrosis Factors α and β

1991 • 26 citations

Prostacyclin analogues inhibit tissue factor expression in the human monocytic cell line THP-1 via a cyclic AMP-dependent mechanism.

1992 • 24 citations

Pentoxifylline inhibits the expression of tissue factor mRNA in endotoxin‐activated human monocytes

1993 • 21 citations

Effect of Cyclic AMP and Cyclic GMP on Thromboplastin (Factor III) Synthesis in Human Monocytes In Vitro

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Evaluation of the use of the luciferase-reporter-gene system for gene-regulation studies involving cyclic AMP-elevating agents

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Beneficial effect of amrinone on murine cardiac allograft survival

1995 • 2 citations