Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-β1 (TGF-β1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

The nucleotide sequence of the rat cytoplasmic β–actin gene

1983 • 1,059 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

1992 • 752 citations

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis

1997 • 737 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function

1996 • 653 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes

1994 • 396 citations

Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.

1986 • 396 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

Mature microglia resemble immature antigen-presenting cells

1998 • 339 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro.

1993 • 303 citations

Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production.

1996 • 290 citations

Inflammatory Signals Induce Neurotrophin Expression in Human Microglial Cells

1998 • 285 citations

Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor

1998 • 283 citations

Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.

1998 • 276 citations

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

1998 • 275 citations

Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor.

1987 • 259 citations

Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions

1994 • 258 citations

Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function.

1988 • 227 citations

Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses

1995 • 225 citations

Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia

1996 • 217 citations

Neuroprotective role of IL-4 against activated microglia.

1993 • 214 citations

Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells

1994 • 203 citations

The CD40 ligand expressed by human B cells costimulates B cell responses.

1995 • 200 citations

The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.

1992 • 198 citations

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.

1995 • 194 citations

Lipopolysaccharide enhances synthesis of brain-derived neurotrophic factor in cultured rat microglia

1997 • 170 citations

Kinetics of Expression of Costimulatory Molecules and Their Ligands in Murine Relapsing Experimental Autoimmune Encephalomyelitis In Vivo

1998 • 169 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

Regulation of microglial activation by TGF-β, IL-10, and CSF-1

1996 • 150 citations

Induction of B cell costimulatory function by recombinant murine CD40 ligand

1994 • 148 citations

T-cell costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture

1995 • 143 citations

IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.

1994 • 127 citations

Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease ¹

1995 • 121 citations

Production of colony‐stimulating factor‐1 (CSF‐1) by mouse astroglia in vitro

1990 • 114 citations

CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts.

1997 • 113 citations

Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents

1997 • 110 citations

Interleukin-11 inhibits macrophage interleukin-12 production.

1997 • 102 citations

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

1996 • 101 citations

Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids.

1993 • 95 citations

Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression

1994 • 93 citations

Neurotrophins and theirtrk receptors in cultured cells of the glial lineage and in white matter of the central nervous system

1995 • 83 citations

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with naïve CD4⁺and CD8⁺T‐cells

1998 • 78 citations

Microglial cells in human brain have phenotypic characteristics related to possible function as dendritic antigen presenting cells

1989 • 76 citations

Myelin basic protein infused into cerebrospinal fluid suppresses experimental autoimmune encephalomyelitis

1991 • 75 citations

Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system

1994 • 74 citations

Differentiation driven by granulocyte-macrophage colony-stimulating factor endows microglia with interferon-γ-independent antigen presentation function

1993 • 68 citations

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with na�ve CD4+ and CD8+ T-cells

1998 • 60 citations

Genomic structure and chromosomal mapping of the murine CD40 gene.

1992 • 58 citations

Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity

1997 • 56 citations

Evidence for transforming growth factor-beta expression in human leptomeningeal cells and transforming growth factor-beta-like activity in human cerebrospinal fluid.

1992 • 56 citations

Interferon-γ promotes cholinergic differentiation of embryonic septal nuclei and adjacent basal forebrain

1994 • 54 citations

FcR cross-linking on monocytes results in impaired T cell stimulatory capacity

1995 • 53 citations

Conditioned Medium from Activated Microglia Promotes Cholinergic Differentiation in the Basal Forebrainin Vitro

1996 • 52 citations

Colony-stimulating factors regulate programmed cell death of rat microglia/brain macrophages in vitro

1995 • 31 citations

Granulocyte-macrophage colony stimulating factor inhibits class II major histocompatibility complex expression and antigen presentation by microglia

1993 • 26 citations

Cloning the rat homolog of the CD28/CTLA-4-ligand B7-1: structural and functional analysis

1995 • 9 citations