Tumor necrosis factor alpha upregulates human microglial cell production of interleukin-10 in vitro

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.

1993 • 821 citations

Interleukin 10 protects mice from lethal endotoxemia.

1993 • 807 citations

Septic shock: pathogenesis

1991 • 743 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis.

1993 • 386 citations

Interleukin-10 production during septicaemia

1994 • 365 citations

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

1992 • 352 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells.

1994 • 328 citations

Interleukin‐10 controls interferon‐γ and tumor necrosis factor production during experimental endotoxemia

1994 • 306 citations

Microglia in human disease, with an emphasis on acquired immune deficiency syndrome.

1991 • 273 citations

Pathogenesis and pathophysiology of bacterial meningitis

1993 • 265 citations

Tumor Necrosis Factor-Alpha Potentiates Glutamate Neurotoxicity in Human Fetal Brain Cell Cultures

1994 • 243 citations

Tumor necrosis factor in the pathogenesis of infectious diseases

1993 • 239 citations

Molecular pathophysiology of bacterial meningitis: Current concepts and therapeutic implications

1990 • 223 citations

Neuroprotective role of IL-4 against activated microglia.

1993 • 214 citations

IL-10 mediates susceptibility to Trypanosoma cruzi infection.

1994 • 199 citations

Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees.

1994 • 189 citations

Cytokine Release from Microglia: Differential Inhibition by Pentoxifylline and Dexamethasone

1992 • 179 citations

Glia, cytokines, and neurotoxicity.

1995 • 178 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

Human microglial cell defense against Toxoplasma gondii. The role of cytokines.

1994 • 159 citations

High Levels Of Interleukin-10 During The Initial Phase Of Fulminant Meningococcal Septic Shock

1995 • 140 citations

IL-10 is induced during HIV-1 infection and is capable of decreasing viral replication in human macrophages.

1994 • 134 citations

Listeria meningitis: identification of a cerebrospinal fluid inhibitor of macrophage listericidal function as interleukin 10.

1993 • 110 citations

Mechanisms of Brain Injury in Bacterial Meningitis: Workshop Summary

1994 • 93 citations

Interleukin-10 and the Monocyte/Macrophage-Induced Inflammatory Response in Septic Shock

1995 • 91 citations

Transforming growth factor-β protects human neurons against β-amyloid-induced injury

1994 • 71 citations

IL-10 Inhibits HIV-1 Replication and Is Induced by Tat

1994 • 69 citations

Interleukin-10 suppresses human immunodeficiency virus-1 replication in vitro in cells of the monocyte/macrophage lineage

1994 • 69 citations

Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system

1994 • 49 citations

Immunocytochemical Detection Of Cytokines In The Lymph Nodes And Brains Of Mice Resistant Or Susceptible To Toxoplasmic Encephalitis

1994 • 42 citations

Temporal differences in the expression of mRNA for IL‐10 and IFN‐γ in the brains and spleens of C57BL/10 mice infected with Toxoplasma gondii

1994 • 41 citations

The Use of Cytokine and C-Reactive Protein Measurements in Cerebrospinal Fluid during Acute Infective Meningitis

1994 • 41 citations

Microglial cell upregulation of HIV-1 expression in the chronically infected promonocytic cell line U1: the role of tumor necrosis factor-α

1992 • 17 citations