Cancer Immunology

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Dendritic cells and the control of immunity

1998 • 14,345 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

2005 • 4,901 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Immunosuppressive Strategies that are Mediated by Tumor Cells

2006 • 1,662 citations

Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

2005 • 1,613 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells

2004 • 1,395 citations

Adaptive immunity maintains occult cancer in an equilibrium state

2007 • 1,307 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

Adoptive T cell therapy using antigen-specific CD8⁺T cell clones for the treatment of patients with metastatic melanoma:In vivopersistence, migration, and antitumor effect of transferred T cells

2002 • 1,187 citations

Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population

2000 • 1,075 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

2003 • 981 citations

Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity

2006 • 829 citations

Cross-Talk between Myeloid-Derived Suppressor Cells and Macrophages Subverts Tumor Immunity toward a Type 2 Response

2007 • 795 citations

Cellular Responses to Viral Infection in Humans: Lessons from Epstein-Barr Virus

2007 • 731 citations

A listing of human tumor antigens recognized by T cells

2001 • 708 citations

Immunostimulatory monoclonal antibodies for cancer therapy

2007 • 596 citations

A critical function for type I interferons in cancer immunoediting

2005 • 574 citations

Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses

2007 • 571 citations

Increased Regulatory T-Cell Fraction Amidst a Diminished CD4 Compartment Explains Cellular Immune Defects in Patients with Malignant Glioma

2006 • 570 citations

Checkpoint Blockade in Cancer Immunotherapy

2006 • 558 citations

Adoptive T cell therapy for cancer in the clinic

2007 • 536 citations

CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma

2007 • 494 citations

Tumor Evasion of the Immune System by Converting CD4+CD25− T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β

2007 • 438 citations

Cross‐presentation: underlying mechanisms and role in immune surveillance

2005 • 435 citations

Combination of p53 Cancer Vaccine with Chemotherapy in Patients with Extensive Stage Small Cell Lung Cancer

2006 • 428 citations

Prophylactic human papillomavirus vaccines

2006 • 422 citations

Randomized Phase IIB Trial of BLP25 Liposome Vaccine in Stage IIIB and IV Non–Small-Cell Lung Cancer

2005 • 416 citations

High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer

2007 • 403 citations

A Pilot Trial of CTLA-4 Blockade with Human Anti-CTLA-4 in Patients with Hormone-Refractory Prostate Cancer

2007 • 397 citations

Vaccines for tumour prevention

2006 • 339 citations

Serological identification of human tumor antigens

1997 • 318 citations

Tumor-Associated CD8+ T Cell Tolerance Induced by Bone Marrow-Derived Immature Myeloid Cells

2005 • 302 citations

Phase I Study of Adoptive T-Cell Therapy Using Antigen-Specific CD8⁺ T Cells for the Treatment of Patients With Metastatic Melanoma

2006 • 293 citations

Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study

2006 • 285 citations

Targeting HER-2/neuin Early Breast Cancer Development Using Dendritic Cells with Staged Interleukin-12 Burst Secretion

2007 • 260 citations

K-ras activation generates an inflammatory response in lung tumors

2005 • 254 citations

Depletion of CD4⁺CD25⁺ human regulatory T cells in vivo: Kinetics of Treg depletion and alterations in immune functions in vivo and in vitro

2007 • 244 citations

Dendritic Cells Loaded With Killed Allogeneic Melanoma Cells can Induce Objective Clinical Responses and MART-1 Specific CD8+ T-cell Immunity

2006 • 233 citations

MUC1 Immunobiology: From Discovery to Clinical Applications

2004 • 221 citations

Long-term culture of human antigen-specific cytotoxic T-cell lines.

1978 • 220 citations

Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer

2005 • 210 citations

Epidermal Growth Factor Receptor Inhibitors in the Treatment of Non–Small-Cell Lung Cancer

2005 • 206 citations

Regulation of Carcinogenesis by IL-5 and CCL11: A Potential Role for Eosinophils in Tumor Immune Surveillance

2007 • 199 citations

Leveraging the Activity of Tumor Vaccines with Cytotoxic Chemotherapy

2005 • 180 citations

Prostate Stem Cell Antigen Vaccination Induces a Long-term Protective Immune Response against Prostate Cancer in the Absence of Autoimmunity

2008 • 170 citations

Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo

2007 • 163 citations

Effect of Dose on Immune Response in Patients Vaccinated With an HER-2/neu Intracellular Domain Protein—Based Vaccine

2004 • 162 citations

Transforming Growth Factor-β and the Immune Response to Malignant Disease

2007 • 158 citations

Tremelimumab (CP-675,206), a Cytotoxic T Lymphocyte–Associated Antigen 4 Blocking Monoclonal Antibody in Clinical Development for Patients with Cancer

2007 • 158 citations

Natural endogenous adjuvants

2004 • 154 citations

Clinical Benefit Associated With Idiotypic Vaccination in Patients With Follicular Lymphoma

2006 • 154 citations

Indoleamine 2,3-Dioxygenase in Immune Suppression and Cancer

2007 • 147 citations

CD8+ T-Cell Content in Diagnostic Lymph Nodes Measured by Flow Cytometry Is a Predictor of Survival in Follicular Lymphoma

2007 • 147 citations

The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma

2006 • 138 citations

Conditions Associated with Antibodies Against the Tumor-Associated Antigen MUC1 and Their Relationship to Risk for Ovarian Cancer

2005 • 138 citations

Three Different Vaccines Based on the 140-Amino Acid MUC1 Peptide with Seven Tandemly Repeated Tumor-Specific Epitopes Elicit Distinct Immune Effector Mechanisms in Wild-Type Versus MUC1-Transgenic Mice with Different Potential for Tumor Rejection

2001 • 135 citations

Identification of Cyclin B1 as a Shared Human Epithelial Tumor-Associated Antigen Recognized by T Cells

2001 • 135 citations

Clinical cancer vaccine trials

2002 • 134 citations

Myeloid-Derived Suppressor Cells

2007 • 133 citations

Specific adoptive therapy of established leukemia with syngeneic lymphocytes sequentially immunized in vivo and in vitro and nonspecifically expanded by culture with Interleukin 2.

1981 • 130 citations

Lessons from randomized phase III studies with active cancer immunotherapies – Outcomes from the 2006 Meeting of the Cancer Vaccine Consortium (CVC)

2007 • 125 citations

Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34+ progenitor-derived dendritic cells

2005 • 123 citations

Individually distinct transplantation antigens of chemically induced mouse tumors

1988 • 113 citations

Incidence of Malignancies in Heart and/or Lung Transplant Recipients: A Single-Institution Experience

2007 • 110 citations

T Cell–Dependent Antibody Responses against Aberrantly Expressed Cyclin B1 Protein in Patients with Cancer and Premalignant Disease

2005 • 102 citations

Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells.

1986 • 102 citations

Human Tumor Antigen MUC1 Is Chemotactic for Immature Dendritic Cells and Elicits Maturation but Does Not Promote Th1 Type Immunity

2005 • 100 citations

Reinstalling Antitumor Immunity by Inhibiting Tumor-Derived Immunosuppressive Molecule IDO through RNA Interference

2006 • 98 citations

Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment

2007 • 92 citations

Phase II Trial of Idiotype Vaccination in Previously Treated Patients With Indolent Non-Hodgkin’s Lymphoma Resulting in Durable Clinical Responses

2006 • 90 citations

Tolerization of Tumor-Specific T Cells Despite Efficient Initial Priming in a Primary Murine Model of Prostate Cancer

2007 • 90 citations

Recognition of tumor glycans by antigen-presenting cells

2005 • 89 citations

Vaccination for Treatment and Prevention of Cancer in Animal Models

2006 • 87 citations

Therapeutic Anti-VEGF Antibodies

2007 • 85 citations

Induction of Tumor Immunity Following Allogeneic Stem Cell Transplantation

2006 • 84 citations

Relationships between regulatory T cells and CD8+ effector populations in patients with squamous cell carcinoma of the head and neck

2006 • 80 citations

Immunogenic HER-2/neu peptides as tumor vaccines

2005 • 76 citations

Sipuleucel-T: A Vaccine for Metastatic, Asymptomatic, Androgen-Independent Prostate Cancer

2007 • 76 citations

Impact of vaccinations and infectious diseases on the risk of melanoma—evaluation of an EORTC case–control study

2003 • 73 citations

Proinflammatory Mediators and Genetic Background in Oncogene Mediated Tumor Progression

2004 • 62 citations

Dendritic Cell Surface Calreticulin Is a Receptor for NY-ESO-1: Direct Interactions between Tumor-Associated Antigen and the Innate Immune System

2006 • 60 citations

Direct analysis of tumor-associated peptide antigens

1994 • 60 citations

Graft-versus-Leukemia Target Antigens in Chronic Myelogenous Leukemia Are Expressed on Myeloid Progenitor Cells

2005 • 56 citations

Tumor Antigens and Tumor Antigen Discovery

2007 • 53 citations

Fas ligand mediates immune privilege and not inflammation in human colon cancer, irrespective of TGF-β expression

2003 • 51 citations

Human tumor-associated antigens identified by monoclonal antibodies

1982 • 47 citations

Molecular Characterization of Virus-induced Autoantibody Responses

2004 • 43 citations

Febrile infectious childhood diseases in the history of cancer patients and matched control

1998 • 30 citations

Monoclonal antibody therapy of B cell lymphoma

2004 • 25 citations

Cetuximab in cancers of the lung and head & neck

2004 • 25 citations

Adenovirus vaccination against neu oncogene exerts long‐term protection from tumorigenesis in BALB/neuT transgenic mice

2006 • 23 citations

Design and Testing of Peptide-Based Cytotoxic T-Cell-Mediated Immunotherapeutics to Treat Infectious Diseases and Cancer

1995 • 20 citations

Immunosurveillance of Virus-induced Tumors

1989 • 13 citations

Sipuleucel-T shows partial advantage in prostate cancer

2006 • 10 citations