Lessons from randomized phase III studies with active cancer immunotherapies – Outcomes from the 2006 Meeting of the Cancer Vaccine Consortium (CVC)

Placebo-Controlled Phase III Trial of Immunologic Therapy with Sipuleucel-T (APC8015) in Patients with Metastatic, Asymptomatic Hormone Refractory Prostate Cancer

2006 • 1,069 citations

Immunotherapy of Hormone-Refractory Prostate Cancer With Antigen-Loaded Dendritic Cells

2000 • 627 citations

Prolongation of Survival in Metastatic Melanoma After Active Specific Immunotherapy With a New Polyvalent Melanoma Vaccine

1992 • 410 citations

Suppression of Antitumor Immunity by IL-10 and TGF-β-Producing T Cells Infiltrating the Growing Tumor: Influence of Tumor Environment on the Induction of CD4+ and CD8+ Regulatory T Cells

2006 • 407 citations

Phase I Study of Sequential Vaccinations With Fowlpox-CEA(6D)-TRICOM Alone and Sequentially With Vaccinia-CEA(6D)-TRICOM, With and Without Granulocyte-Macrophage Colony-Stimulating Factor, in Patients With Carcinoembryonic Antigen–Expressing Carcinomas

2004 • 298 citations

A Clinical Development Paradigm for Cancer Vaccines and Related Biologics

2006 • 272 citations

Can science be a business? Lessons from biotech.

2006 • 268 citations

Active specific immunotherapy for melanoma: phase I trial of allogeneic lysates and a novel adjuvant.

1988 • 239 citations

Adjuvant Immunotherapy of Resected, Intermediate-Thickness, Node-Negative Melanoma With an Allogeneic Tumor Vaccine: Overall Results of a Randomized Trial of the Southwest Oncology Group

2002 • 222 citations

Phase III Study of Adjuvant Vaccination With Bec2/Bacille Calmette-Guerin in Responding Patients With Limited-Disease Small-Cell Lung Cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study)

2005 • 218 citations

Adjuvant Immunotherapy of Resected, Intermediate-Thickness, Node-Negative Melanoma With an Allogeneic Tumor Vaccine: Impact of HLA Class I Antigen Expression on Outcome

2002 • 207 citations

Immunotherapy (APC8015, Provenge®) targeting prostatic acid phosphatase can induce durable remission of metastatic androgen‐independent prostate cancer: A phase 2 trial

2004 • 187 citations

Active-specific immunotherapy for melanoma.

1990 • 186 citations

Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guérin.

1999 • 166 citations

Correlation of specific immune responses with survival in melanoma patients with distant metastases receiving polyvalent melanoma cell vaccine.

1998 • 162 citations

Enhancing the Effect of THERATOPE STn-KLH Cancer Vaccine in Patients with Metastatic Breast Cancer by Pretreatment with Low-Dose Intravenous Cyclophosphamide

1996 • 155 citations

Prolonged Survival of Patients Receiving Active Immunotherapy With Canvaxin Therapeutic Polyvalent Vaccine After Complete Resection of Melanoma Metastatic to Regional Lymph Nodes

2002 • 148 citations

Vaccine therapy for melanoma: Current status and future directions

2007 • 98 citations

Clinical outcome of breast and ovarian cancer patients treated with high-dose chemotherapy, autologous stem cell rescue and THERATOPE® STn-KLH cancer vaccine

2000 • 89 citations

Association of HLA phenotype with response to active specific immunotherapy of melanoma.

1992 • 81 citations

Effect of Renal Cell Carcinomas on the Development of Type 1 T-Cell Responses

2004 • 75 citations

Rationale for the Clinical Development of STn-KLH (Theratope®) and Anti—MUC-1 Vaccines in Breast Cancer

2003 • 75 citations

Polyvalent melanoma cell vaccine induces delayed-type hypersensitivity and in vitro cellular immune response.

1994 • 71 citations

Enhancing efficacy of therapeutic vaccinations by combination with other modalities

2007 • 67 citations

Active immunotherapy of metastatic melanoma with allogeneic melanoma lysates and interferon alpha.

2002 • 59 citations

Ganglioside expression in lung cancer cell lines

1997 • 59 citations

Development of the PANVAC™-VF vaccine for pancreatic cancer

2006 • 59 citations

Enhancing cancer vaccines with immunomodulators

2007 • 55 citations

Natural Killer andNK-LikeT-Cell Activation in Colorectal Carcinoma Patients Treated with Autologous Tumor-Derived Heat Shock Protein 96

2005 • 45 citations

The Role of Cancer Vaccines Following Autologous Stem Cell Rescue in Breast and Ovarian Cancer Patients: Experience with the STn-KLH Vaccine (Theratope®)

2003 • 35 citations

Is the survival of melanoma patients receiving polyvalent melanoma cell vaccine linked to the human leukocyte antigen phenotype of patients?

1998 • 33 citations

A phase II trial comparing five dose levels of BEC2 anti-idiotypic monoclonal antibody vaccine that mimics GD3 ganglioside

2004 • 32 citations

Recombinant, tumour-derived idiotype vaccination for indolent B cell non-Hodgkin’s lymphomas: a focus on FavId™

2005 • 31 citations

Humoral Immune Response to a Therapeutic Polyvalent Cancer Vaccine After Complete Resection of Thick Primary Melanoma and Sentinel Lymphadenectomy

2003 • 29 citations

Long-term follow-up of patients concomitantly treated with hormone therapy in a prospective controlled randomized multicenter clinical study comparing STn-KLH vaccine with KLH control in stage IV breast cancer following first-line chemotherapy

2004 • 25 citations

Humoral immune-response to naturally occurring STn in metastatic breast cancer patients (MBC pts) treated with STn-KLH vaccine

2004 • 16 citations

Extended survival in second-line pancreatic cancer after therapeutic vaccination

2005 • 16 citations

Significant impact of HLA class I allele expression on outcome in melanoma patients treated with an allogeneic melanoma cell lysate vaccine. Final analysis of SWOG-9035

2004 • 14 citations

Autologous renal cell cancer vaccines using heat shock protein-peptide complexes

2006 • 13 citations

Long-term follow-up of patients concomitantly treated with hormone therapy in a prospective controlled randomized multicenter clinical study comparing STn-KLH vaccine with KLH control in stage IV breast cancer following first-line chemotherapy

2004 • 13 citations

Significant impact of HLA class I allele expression on outcome in melanoma patients treated with an allogeneic melanoma cell lysate vaccine. Final analysis of SWOG-9035

2004 • 10 citations

Humoral immune-response to naturally occurring STn in metastatic breast cancer patients (MBC pts) treated with STn-KLH vaccine

2004 • 6 citations

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