Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

1997 • 5,683 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

The Telomerase Catalytic Subunit Is a Widely Expressed Tumor-Associated Antigen Recognized by Cytotoxic T Lymphocytes

1999 • 574 citations

CD4⁺T cells eliminate MHC class II-negative cancer cellsin vivoby indirect effects of IFN-γ

1999 • 378 citations

Telomerase mRNA-Transfected Dendritic Cells Stimulate Antigen-Specific CD8+ and CD4+ T Cell Responses in Patients with Metastatic Prostate Cancer

2005 • 352 citations

Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma

2001 • 271 citations

An investigational new drug treatment program for patients with gemcitabine

1999 • 265 citations

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

2000 • 259 citations

Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes

2004 • 254 citations

Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer

2006 • 233 citations

CD4+/CD25+ Regulatory Cells Inhibit Activation of Tumor-Primed CD4+ T Cells with IFN-γ-Dependent Antiangiogenic Activity, as well as Long-Lasting Tumor Immunity Elicited by Peptide Vaccination

2003 • 192 citations

Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12VAL) peptide vaccination of a patient, recognize 12VAL-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation

1997 • 163 citations

Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections

1999 • 153 citations

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

2004 • 126 citations

HER-2/neu and hTERT Cryptic Epitopes as Novel Targets for Broad Spectrum Tumor Immunotherapy

2002 • 121 citations

Identification of human telomerase reverse transcriptase–derived peptides that induce HLA-A24–restricted antileukemia cytotoxic T lymphocytes

2001 • 117 citations

Immunization of Patients with the hTERT:540-548 Peptide Induces Peptide-Reactive T Lymphocytes That Do Not Recognize Tumors Endogenously Expressing Telomerase

2004 • 111 citations

High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy

2004 • 107 citations

Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase.

2001 • 103 citations

Identification of HLA DR7-restricted epitopes from human telomerase reverse transcriptase recognized by CD4+ T-helper cells.

2002 • 95 citations

Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells

2002 • 92 citations

Diagnosis of Pancreatic Cancer by Detecting Telomerase Activity in Pancreatic Juice: Comparison With K- Ras Mutations

1999 • 88 citations

Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes.

2003 • 76 citations

Is selection for TCR affinity a factor in cytokine polarization?

2002 • 69 citations

Epitope spreading upon P815 tumor rejection triggered by vaccination with the single class I MHC-restricted peptide P1A

2001 • 53 citations

IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation

2003 • 49 citations

Telomerase activity in human solid tumors. Diagnostic utility and clinical applications.

1999 • 44 citations

Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient with pancreatic cancer

1998 • 44 citations

Telomerase as a possible target for anticancer therapy

1999 • 33 citations

Rejection of Intraocular Tumors by CD4+ T Cells Without Induction of Phthisis

2001 • 32 citations

Differential gene expression of human telomerase-associated protein hTERT and TEP1 in human hematopoietic cells

1999 • 26 citations