The key role of macrophages in the immunopathogenesis of inflammatory bowel disease

Dendritic cells and the control of immunity

1998 • 14,345 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Secretory products of macrophages.

1987 • 2,670 citations

Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease

1999 • 2,656 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Experimental models of inflammatory bowel disease

1995 • 1,215 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

1994 • 1,175 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking

1998 • 832 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins

1993 • 660 citations

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

1996 • 635 citations

Mechanism of Lysozyme Action

1969 • 614 citations

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

1997 • 582 citations

Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease

1994 • 578 citations

Recognition of Gram-negative bacteria and endotoxin by the innate immune system

1999 • 577 citations

Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.

1993 • 532 citations

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10

1992 • 516 citations

Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin

1990 • 515 citations

A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats

1999 • 502 citations

Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

1991 • 491 citations

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1.

1995 • 472 citations

Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils.

1993 • 460 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.

1994 • 407 citations

Isolation and functional characterization of human intestinal mucosal lymphoid cells.

1977 • 403 citations

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

1990 • 402 citations

Randomised controlled trial of CDP571 antibody to tumour necrosis factor-α in Crohn's disease

1997 • 400 citations

Bioactive IL-18 Expression Is Up-Regulated in Crohn’s Disease

1999 • 399 citations

Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease

1996 • 388 citations

In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes.

1996 • 381 citations

Recognizing death: the phagocytosis of apoptotic cells

1998 • 381 citations

Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein

1996 • 380 citations

Number, size, and distribution of Peyer's patches in the human small intestine: Part I The development of Peyer's patches

1965 • 376 citations

Fc receptors: Rubor redux

1994 • 361 citations

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch.

1996 • 360 citations

Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.

1996 • 349 citations

Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease

1992 • 342 citations

Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance

1998 • 327 citations

Tumor necrosis factor-?, interleukin-1?, and interleukin-6 expression in inflammatory bowel disease

1992 • 325 citations

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification

1992 • 323 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

Evidence for continuous stimulation of interleukin-6 production in Crohn's disease

1992 • 302 citations

C-reactive protein and the acute phase response

1982 • 297 citations

Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa

1995 • 293 citations

Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation.

1994 • 282 citations

Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease.

1996 • 280 citations

The Macrophage Scavenger Receptor Type A Is Expressed by Activated Macrophages and Protects the Host Against Lethal Endotoxic Shock

1997 • 275 citations

Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes.

1994 • 270 citations

Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains.

1994 • 268 citations

The selective engulfment of apoptotic bodies by dendritic cells is mediated by the αvβ3 integrin and requires intracellular and extracellular calcium

1997 • 262 citations

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

1994 • 247 citations

Molecular Cloning of F4/80, a Murine Macrophage-restricted Cell Surface Glycoprotein with Homology to the G-protein-linked Transmembrane 7 Hormone Receptor Family

1996 • 230 citations

IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease

1994 • 229 citations

Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence.

1995 • 226 citations

Transcription factors that regulate monocyte/macrophage differentiation

1998 • 222 citations

Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family

1993 • 214 citations

Enhanced synthesis of neutrophil-activating peptide-I/interleukin-8 in active ulcerative colitis

1992 • 206 citations

Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment.

1996 • 202 citations

Myeloid dendritic cells

1999 • 201 citations

Discrimination of Human Macrophages and Dendritic Cells by Means of Monoclonal Antibodies

1986 • 199 citations

Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease

1991 • 197 citations

Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells

1993 • 196 citations

High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis.

1991 • 193 citations

Isolation and phenotypic characterization of colonic macrophages

1998 • 184 citations

Growth Factors in Inflammatory Bowel Disease

1999 • 179 citations

Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa

1995 • 179 citations

Expression of interleukin 1β and interleukin 1β converting enzyme by intestinal macrophages in health and inflammatory bowel disease

1998 • 178 citations

Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses.

1995 • 177 citations

Interleukin 8: cells of origin in inflammatory bowel disease.

1996 • 177 citations

Human Peyer's patches: an immunohistochemical study.

1986 • 158 citations

Human Macrophage Metalloelastase. GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION, GENE LINKAGE, AND TISSUE-SPECIFIC EXPRESSION

1995 • 156 citations

Relationship of functional and antigenic interleukin 6 to disease activity in inflammatory bowel disease

1993 • 152 citations

In Situ Expression of Interleukin-10 in Noninflamed Human Gut and in Inflammatory Bowel Disease

1998 • 152 citations

Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa—implications for pathogenesis

1995 • 145 citations

Macrophage subpopulations in lamina propria of normal and inflamed colon and terminal ileum.

1989 • 140 citations

Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation.

1992 • 138 citations

5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease.

1991 • 136 citations

Heterogeneity of HLA-DR-positive histiocytes in human intestinal lamina propria: a combined histochemical and immunohistological analysis.

1983 • 130 citations

Interleukin 1 in Crohn's disease.

1987 • 127 citations

Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease.

1989 • 125 citations

Distribution of macrophages and granulocytes expressing L1 protein (calprotectin) in human Peyer's patches compared with normal ileal lamina propria and mesenteric lymph nodes.

1993 • 123 citations

Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14+L1+ monocyte derived cells.

1995 • 120 citations

Colony stimulating factors, cytokines and monocyte-macrophages-some controversies

1993 • 119 citations

Leukocytes of the intestinal muscularis: their phenotype and isolation

1998 • 118 citations

Cytokine production in patients with inflammatory bowel disease.

1992 • 116 citations

Human macrophage activation. Modulation of mannosyl, fucosyl receptor activity in vitro by lymphokines, gamma and alpha interferons, and dexamethasone.

1985 • 116 citations

Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria.

1993 • 115 citations

Peripheral blood monocyte cytokine production and acute phase response in inflammatory bowel disease.

1992 • 113 citations

The Structure of the Colonic Mucosa

1965 • 111 citations

Interleukin 8 secretion by colonic crypt cells in vitro: response to injury suppressed by butyrate and enhanced in inflammatory bowel disease.

1995 • 108 citations

Isolation of a novel macrophage-specific gene by differential cDNA analysis

1995 • 108 citations

Macrophage heterogeneity in normal colonic mucosa and in inflammatory bowel disease.

1988 • 107 citations

Macrophage turnover in Crohn's disease and ulcerative colitis

1978 • 104 citations

Multiple Pathways for the Initiation of T Helper 2 (Th2) Responses

1997 • 103 citations

Lymph-borne (veiled) dendritic cells can acquire and present intestinally administered antigens.

1991 • 102 citations

Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells

1997 • 91 citations

Dendritic cells and scavenger macrophages in chronic inflammatory bowel disease.

1989 • 87 citations

Macrophage-restricted molecules: role in differentiation and activation

1999 • 82 citations

Myeloid-specific gene expression

1998 • 78 citations

1 Regulation of the mucosal epithelial barrier

1996 • 75 citations

Isolation and preliminary characterization of human intestinal macrophages

1983 • 72 citations

Immunohistochemical Characterisation of Macrophages in Human Liver and Gastrointestinal Tract: Expression of CD4, HLA-DR, OKM1, and the Mature Macrophage Marker 25F9 in Normal and Diseased Tissue

1987 • 70 citations

Interleukin 2 receptor expression by macrophages in inflammatory bowel disease.

1988 • 70 citations

CD14+CD34+ Peripheral Blood Mononuclear Cells Migrate Across Endothelium and Give Rise to Immunostimulatory Dendritic Cells

1998 • 67 citations

ACID HYDROLASES IN MONOCYTES FROM PATIENTS WITH INFLAMMATORY BOWEL DISEASE, CHRONIC LIVER DISEASE, AND RHEUMATOID ARTHRITIS

1978 • 66 citations

Tumor Necrosis Factor-α Is Not Elevated in Children with Inflammatory Bowel Disease

1991 • 64 citations

Veiled cells in chronic idiopathic inflammatory bowel disease.

1984 • 62 citations

Lymphocyte and macrophage subpopulations in pelvic ileal pouches.

1991 • 59 citations

Distribution of human colonic dendritic cells and macrophages

1996 • 58 citations

Changes in phenotypically distinct mucosal macrophage populations may be a prerequisite for the development of inflammatory bowel disease

1991 • 57 citations

Antimicrobial peptides in the gastrointestinal tract.

1997 • 48 citations

cDNA cloning and characterization of human monocyte/macrophage serine esterase-1

1991 • 48 citations

Crohn's disease monocytes are primed for accentuated release of toxic oxygen metabolites

1993 • 45 citations

Increased Expression of Interleukin-8 mRNA in Ulcerative Colitis and Crohnʼs Disease Mucosa and Epithelial Cells

1995 • 41 citations

Differential lamina propria cell migration via basement membrane pores of inflammatory bowel disease mucosa

1998 • 40 citations

The accessory cell populations in ulcerative colitis: A comparison between the colon and appendix in colitis and acute appendicitis

1997 • 38 citations

Chronic inflammatory bowel disease--increased plasminogen activator secretion by mononuclear phagocytes.

1982 • 37 citations

Potential role of the mannose receptor in antigen transport

1999 • 36 citations

Positive and negative regulation of the myeloid dendritic cell lineage

1999 • 34 citations

Electron Microscopy of Mucosa of Small Intestine

1963 • 32 citations

Monocytes in Inflammatory Bowel Disease: Monocyte and Serum Lysosomal Enzyme Activity

1980 • 32 citations

Mononuclear phagocyte system of human Peyer's patches: an immunohistochemical study using monoclonal antibodies.

1989 • 26 citations

Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines.

1995 • 26 citations

Investigation of the expression of IL-1β converting enzyme and apoptosis in normal and inflammatory bowel disease (IBD) mucosal macrophages

1999 • 24 citations

Accessory cells in Crohn's disease of the terminal ileum

1996 • 23 citations

Phenotypic and functional characterisation of myofibroblasts, macrophages, and lymphocytes migrating out of the human gastric lamina propria following the loss of epithelial cells

1999 • 21 citations

Cytokines and the gut

1997 • 18 citations

A novel human macrophage-derived intestinal mucin secretagogue: Implications for the pathogenesis of inflammatory bowel disease

1993 • 18 citations

Accessory cells in physiological lymphoid tissue from the intestine: an immunohistochemical study

1996 • 16 citations

Lessons for human inflammatory bowel disease from experimental models

1999 • 14 citations

Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease.

1988 • 11 citations