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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

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A family of human receptors structurally related to Drosophila Toll

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Structure and Function of Lipopolysaccharide Binding Protein

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Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.

1993 • 845 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

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Soluble CD14 participates in the response of cells to lipopolysaccharide.

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The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

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ANIMAL MODELS OF SEPSIS AND SHOCK

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Bacterial Endotoxin: Chemical Constitution, Biological Recognition, Host Response, and Immunological Detoxification

1996 • 467 citations

Crystal Structure of Human BPI and Two Bound Phospholipids at 2.4 Angstrom Resolution

1997 • 358 citations

Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection

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Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages.

1989 • 353 citations

The Lives of a Cell: Notes of a Biology Watcher

1975 • 304 citations

A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis.

1988 • 224 citations

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The Lives of a Cell: Notes of a Biology Watcher

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Cloning of the cDNA of a Human Neutrophil Bactericidal Protein

1989 • 203 citations

Targeted Deletion of the Lipopolysaccharide (LPS)-binding Protein Gene Leads to Profound Suppression of LPS Responses Ex Vivo, whereas In Vivo Responses Remain Intact

1997 • 179 citations

Complete cDNA encoding human phospholipid transfer protein from human endothelial cells.

1994 • 178 citations

Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms

1993 • 159 citations

Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins

1989 • 150 citations

Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid.

1997 • 145 citations

Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism.

1996 • 144 citations

Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin

1998 • 143 citations

Lipopolysaccharide (LPS)-binding Proteins BPI and LBP Form Different Types of Complexes with LPS

1997 • 126 citations

Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation.

1996 • 123 citations

Chemistry and Algebra

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Phagocytosis of Gram-negative bacteria by a unique CD14-dependent mechanism

1997 • 119 citations

Molecules and mechanisms operating in septic shock: lessons from knockout mice

1997 • 103 citations

The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105

1998 • 97 citations

Phosphatidylinositides Bind to Plasma Membrane CD14 and Can Prevent Monocyte Activation by Bacterial Lipopolysaccharide

1998 • 94 citations

CD14-deficient mice are exquisitely insensitive to the effects of LPS.

1995 • 70 citations

Point Mutagenesis of Positively Charged Amino Acids of Cholesteryl Ester Transfer Protein: Conserved Residues within the Lipid Transfer/Lipopolysaccharide Binding Protein Gene Family Essential for Function

1995 • 30 citations

Sepsis and septic shock.

1997 • 22 citations