Expression of interleukin 1β and interleukin 1β converting enzyme by intestinal macrophages in health and inflammatory bowel disease

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Cleavage of structural proteins during the assemble of the head of bacterio-phage T4

1970 • 5,738 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

1994 • 725 citations

INFECTIONS OF THE GASTRO-INTESTINAL TRACT

1980 • 631 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

1990 • 402 citations

Interleukin 1: the first interleukin

1990 • 342 citations

Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.

1990 • 333 citations

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification

1992 • 323 citations

Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa

1995 • 293 citations

Significance of systemic endotoxaemia in inflammatory bowel disease.

1995 • 228 citations

Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment.

1996 • 202 citations

Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells

1993 • 196 citations

Comparison of delayed release 5 aminosalicylic acid (mesalazine) and sulphasalazine in the treatment of mild to moderate ulcerative colitis relapse.

1988 • 193 citations

Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa

1995 • 179 citations

Release of IL-1 from mononuclear phagocytes.

1991 • 169 citations

Macrophage subpopulations in lamina propria of normal and inflamed colon and terminal ileum.

1989 • 140 citations

Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation.

1992 • 138 citations

5-Aminosalicylic acid is a potent inhibitor of interleukin 1 beta production in organ culture of colonic biopsy specimens from patients with inflammatory bowel disease.

1991 • 136 citations

Heterogeneity of HLA-DR-positive histiocytes in human intestinal lamina propria: a combined histochemical and immunohistological analysis.

1983 • 130 citations

Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease.

1989 • 125 citations

Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14+L1+ monocyte derived cells.

1995 • 120 citations

Endotoxaemia in active Crohn's disease. Treatment with whole gut irrigation and 5-aminosalicylic acid.

1986 • 119 citations

Peripheral blood monocyte cytokine production and acute phase response in inflammatory bowel disease.

1992 • 113 citations

Expression, Refolding, and Autocatalytic Proteolytic Processing of the Interleukin-1β-converting Enzyme Precursor

1995 • 107 citations

Migration of human intestinal lamina propria lymphocytes, macrophages and eosinophils following the loss of surface epithelial cells

1997 • 91 citations

Interleukin 2 receptor expression by macrophages in inflammatory bowel disease.

1988 • 70 citations

Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme.

1995 • 52 citations

Macrophage apoptosis in the absence of active interleukin-1β-converting enzyme

1995 • 30 citations

Circulating lipid A antibodies despite absence of systemic endotoxemia in patients with Crohn's disease

1984 • 28 citations