Evidence for continuous stimulation of interleukin-6 production in Crohn's disease

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.

1976 • 3,140 citations

Development of a Crohn's Disease Activity Index

1976 • 3,024 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial.

1989 • 1,035 citations

THE PLASMA PROTEINS

1960 • 934 citations

Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

1989 • 856 citations

Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

1986 • 731 citations

Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.

1986 • 585 citations

Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

1986 • 577 citations

Corticotropin-Releasing Activity of Monokines

1985 • 500 citations

Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.

1989 • 470 citations

Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

1988 • 458 citations

Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1.

1985 • 423 citations

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

1990 • 402 citations

Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro.

1986 • 398 citations

Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis

1991 • 350 citations

An index of inflammatory activity in patients with Crohn's disease.

1980 • 340 citations

The acute phase response to injury and infection

1985 • 332 citations

Serum levels of C‐reactive protein in Crohn's disease and ulcerative colitis

1982 • 311 citations

Intestinal permeability in patients with Crohn's disease and their healthy relatives

1989 • 305 citations

Recombinant human B cell stimulatory factor 2 (BSF‐2/IFN‐β2) regulates β‐fibrinogen and albumin mRNA levels in Fao‐9 cells

1987 • 299 citations

Plasma clearance, organ distribution and target cells of interleukin‐6/hepatocyte‐stimulating factor in the rat

1988 • 298 citations

Interleukin 6 (IL-6) in serum and urine of renal transplant recipients.

1988 • 265 citations

The serum interleukin 6 response to elective surgery.

1989 • 256 citations

Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection.

1989 • 244 citations

Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages

1988 • 234 citations

Genes coding for RNA polymerase β subunit in bacteria

1988 • 225 citations

The Clinical Significance of Serum C Reactive Protein Levels in Crohnʼs Disease

1988 • 177 citations

Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation

1989 • 172 citations

Assessment of appropriate laboratory measurements to supplement the Crohn's disease activity index.

1981 • 151 citations

Interleukin 1 in Crohn's disease.

1987 • 127 citations

Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta.

1982 • 125 citations

Serum concentration of 19 serum proteins in Crohn's disease and ulcerative colitis

1971 • 122 citations

Serum amyloid A protein compared with C‐reactive protein, alpha 1‐antichymotrypsin and alpha 1‐acid glycoprotein as a monitor of inflammatory bowel disease

1987 • 97 citations

Measurement of serum proteins during attacks of ulcerative colitis as a guide to patient management.

1979 • 71 citations

The Clinical Significance of Seromucoids in Regional Ileitis and Ulcerative Colitis

1958 • 70 citations

Human hepatocyte-stimulating factor-III and interleukin-6 are structurally and immunologically distinct but regulate the production of the same acute phase plasma proteins

1989 • 65 citations

Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating factors interleukin 6 and interferon gamma.

1990 • 63 citations

Clinical and Laboratory Indicators of Extent of Ulcerative Colitis

1988 • 60 citations

Inflammatory bowel diseases—Basic research and clinical implications

1989 • 60 citations

O‐ and N‐glycosylation lead to different molecular mass forms of human monocyte interleukin‐6

1989 • 60 citations

Importance of Laboratory Parameters in the Evaluation of Crohnʼs Disease Activity

1986 • 57 citations

Induction of alpha 1-acid glycoprotein by recombinant human interleukin-1 in rat hepatoma cells.

1988 • 52 citations

Production of B cell stimulatory factor-2/interleukin-6 activity by human endothelial cells

1988 • 48 citations

The inflammation mediators interleukin 1 and hepatocyte-stimulating factor are differently regulated in human monocytes

1987 • 43 citations

Endotoxin-Induced Microclots in Ulcerative Colitis and Crohn's Disease

1980 • 33 citations

Disease Activity and Serum Proteins in Ulcerative Colitis Immunochemical Quantitation

1975 • 26 citations

Serum Levels of β₂-Microglobulin — A New Marker of Activity in Crohn's Disease

1979 • 26 citations

[Detection of endotoxemia in patients with cryptogenic inflammatory enterocolitis].

1979 • 24 citations

Endotoxaemia in Patients with Crohn’s Disease: A Longitudinal Study of Elastase/α1-Proteinase Inhibitor and Limulus-Amoebocyte-Lysate Reactivity

1988 • 7 citations