Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38− Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

Erythropoietin

1991 • 852 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

1996 • 589 citations

Hematopoietic regulators: redundancy or subtlety?

1993 • 473 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.

1996 • 393 citations

Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators

1991 • 369 citations

The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells

1996 • 364 citations

Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin.

1996 • 360 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Control of programmed cell death in normal and leukemic cells: new implications for therapy

1993 • 297 citations

Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1988 • 296 citations

Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population

1996 • 281 citations

Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice

1996 • 278 citations

Treatment of genetic defects in hematopoietic cell function by gene transfer

1991 • 225 citations

Ex vivo expansion of hematopoietic precursors, progenitors, and stem cells: the next generation of cellular therapeutics

1996 • 224 citations

Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors.

1992 • 224 citations

Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo

1996 • 221 citations

Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3

1996 • 220 citations

Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro.

1988 • 213 citations

Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia.

1996 • 192 citations

Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice

1995 • 177 citations

CD34+ human marrow cells that express low levels of Kit protein are enriched for long-term marrow-engrafting cells

1996 • 160 citations

Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity.

1995 • 154 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 145 citations

Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division

1995 • 140 citations

Human primitive hematopoietic progenitor cells are more enriched in KITlow cells than in KIThigh cells

1993 • 138 citations

Human CD34+ HLA-DR- bone marrow cells contain progenitor cells capable of self-renewal, multilineage differentiation, and long-term in vitro hematopoiesis.

1991 • 132 citations

Biology of flt3 ligand and receptor.

1995 • 120 citations

Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture

1991 • 117 citations

FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver

1995 • 112 citations

Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro

1996 • 110 citations

Functional differences between CD38- and DR- subfractions of CD34+ bone marrow cells

1994 • 104 citations

Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells

1994 • 94 citations

Methodology of long-term culture of human hemopoietic cells

1991 • 91 citations

Isolation and characterization of human hematopoietic progenitor cells: an effective method for positive selection of CD34+ cells.

1992 • 89 citations

c-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine-supplemented culture.

1994 • 87 citations

The in vitro response of phenotypically defined mouse stem cells and myeloerythroid progenitors to single or multiple growth factors.

1991 • 86 citations

Growth factor requirement for survival in cell-cycle dormancy of primitive murine lymphohematopoietic progenitors

1993 • 81 citations

Interferon gamma selectively inhibits very primitive CD342+CD38- and not more mature CD34+CD38+ human hematopoietic progenitor cells.

1994 • 67 citations

Apoptosis in the immune system

1994 • 66 citations

Thrombopoietin Suppresses Apoptosis and Behaves as a Survival Factor for the Human Growth Factor‐Dependent Cell Line, M07e

1996 • 58 citations

Interleukin-1 alpha enhances the in vitro survival of purified murine granulocyte-macrophage progenitor cells in the absence of colony- stimulating factors

1988 • 49 citations

Activity of the ligand for c‐mpl, thrombopoietin, in early haemopoiesis

1996 • 33 citations

Low levels of erythroid and myeloid progenitors in thrombopoietin-and c- mpl-deficient mice

1996 • 18 citations

Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells

1994 • 16 citations

Interleukin-3 and granulocyte colony-stimulating factor as survival factors in murine hemopoietic stem cells in vitro.

1992 • 15 citations

Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells

1996 • 14 citations

Promotion of survival and proliferation by interleukin 3, fcil‐ligand and erythropoietin on early and late appearing spleen colony forming units in culture

1993 • 10 citations

Transforming growth factor-beta potently inhibits the viability- promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells

1995 • 8 citations