Mutant Rac1B expression in Dictyostelium: Effects on morphology, growth, endocytosis, development, and the actin cytoskeleton

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation

1998 • 665 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration

1980 • 589 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity

1999 • 546 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

Regulation of receptor-mediated endocytosis by Rho and Rac

1996 • 386 citations

Rho effectors and reorganization of actin cytoskeleton

1997 • 379 citations

Localization of actin and myosin for the study of ameboid movement in Dictyostelium using improved immunofluorescence.

1984 • 306 citations

Mechanisms of phagocytosis

1996 • 265 citations

Functional diversity in the dynamin family

1999 • 256 citations

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

2000 • 238 citations

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis.

1996 • 216 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

Rac mediates growth factor-induced arachidonic acid release

1995 • 207 citations

Cloning vectors for the production of proteins in Dictyostelium discoideum

1995 • 206 citations

Regulation of endocytic traffic by Rho family GTPases

2000 • 198 citations

A Transformation Vector for Dictyostelium discoideum with a New Selectable Marker bsr

1993 • 198 citations

The effector interactions of p21ras

1993 • 193 citations

Cdc42Hs, but Not Rac1, Inhibits Serum-stimulated Cell Cycle Progression at G1/S through a Mechanism Requiring p38/RK

1997 • 191 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

1994 • 171 citations

The Use of Computers in Understanding How Animal Cells Crawl

1995 • 155 citations

Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs

1996 • 141 citations

A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis.

1996 • 140 citations

The small GTPases Rac and Rho as regulators of secretion in mast cells

1995 • 137 citations

Use of a fusion protein between GFP and an actin-binding domain to visualize transient filamentous-actin structures

1998 • 136 citations

An efficient site-directed mutagenesis method based on PCR.

1994 • 129 citations

Cell adhesion and Rho small GTPases

1999 • 105 citations

Inducible expression of calmodulin antisense RNA in Dictyostelium cells inhibits the completion of cytokinesis.

1992 • 104 citations

Activation of Myosin-I by Members of the Ste20p Protein Kinase Family

1996 • 100 citations

Cytokinesis: an emerging unified theory for eukaryotes?

1999 • 100 citations

Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.

1994 • 93 citations

A novel role for clathrin in cytokinesis

1997 • 90 citations

Interacting signaling pathways controlling multicellular development in Dictyostelium

1996 • 87 citations

Mas Oncogene Signaling and Transformation Require the Small GTP-Binding Protein Rac

1998 • 85 citations

Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A

1992 • 82 citations

Role of Dictyostelium racE in cytokinesis: mutational analysis and localization studies by use of green fluorescent protein.

1997 • 75 citations

Cloning and characterization of seven novel Dictyostelium discoideum rac-related genes belonging to the rho family of GTPases

1993 • 68 citations

Differential Effect of Rac and Cdc42 on p38 Kinase Activity and Cell Cycle Progression of Nonadherent Primary Mouse Fibroblasts

2000 • 63 citations

Rho Family Proteins and Regulation of the Actin Cytoskeleton

1999 • 59 citations

Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex.

1996 • 58 citations

Rho GTPases in Development

1999 • 56 citations

Clathrin plays a novel role in the regulation of cell polarity, pseudopod formation, uropod stability and motility in Dictyostelium

2000 • 55 citations

Localization of actin in Dictyostelium amebas by immunofluorescence

1978 • 43 citations

Mutational and Kinetic Analyses of the GTPase-Activating Protein (GAP)-p21 Interaction: The C-Terminal Domain of GAP Is Not Sufficient for Full Activity

1992 • 42 citations

Regulation of the Discoidin I gamma gene in Dictyostelium discoideum: identification of individual promoter elements mediating induction of transcription and repression by cyclic AMP.

1990 • 42 citations

Regulation of Cell-Fate Determination in Dictyostelium

1999 • 38 citations

Genetic approaches to cytoskeleton function and the control of cell motility

1989 • 36 citations

[40] Measurement of actin polymerization and cross-linking in agonist-stimulated cells

1991 • 35 citations

Rac GTPases localize at sites of actin reorganization during dynamic remodeling of the cytoskeleton of normal embryonic fibroblasts

1999 • 29 citations

Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid

1998 • 28 citations

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.

1997 • 27 citations

Genetic networks that regulate development in Dictyostelium cells.

1996 • 25 citations

Cell Behavior and Actomyosin Organization in Dictyostelium During Substrate Exploration.

1991 • 23 citations

Intracellular Regulation: Rac and Bcr regulate phagocytic phoxes

1995 • 22 citations

[34] Microinjection of Rho and Rac into quiescent Swiss 3T3 cells

1995 • 21 citations

Blocking the ends of transforming DNA enhances gene targeting in Dictyostelium

1997 • 15 citations

Molecular genetic characterization of epitope-specific monoclonal antibodies against the myc family proteins.

1990 • 13 citations

The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility

1998 • 13 citations

Molecular genetics of cell migration: Dictyostelium as a model system

1991 • 11 citations

Cytokinesis: A regulatory role for Ras-related proteins?

1997 • 8 citations

IMMUNOAFFINITY PURIFICATION

1994 • 8 citations