rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

[1] Measurement of molecular weights by electrophoresis on SDS-acrylamide gel

1972 • 1,733 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

The locomotion of fibroblasts in culture

1971 • 955 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

Small GTP-Binding Proteins

1992 • 526 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.

1990 • 277 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

1991 • 259 citations

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1993 • 223 citations

Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger

1993 • 206 citations

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

1993 • 200 citations

Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility.

1994 • 199 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product.

1988 • 178 citations

Locomotory activity of epithelial cells in culture

1975 • 168 citations

Botulinum ADP‐ribosyltransferase C3

1988 • 162 citations

Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins.

1992 • 159 citations

Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor

1988 • 156 citations

Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.

1992 • 147 citations

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-rafcarrying retrovirus

1987 • 145 citations

A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation.

1992 • 144 citations

Purification of the 22 kDa protein substrate of botulinum ADP‐ribosyltransferase C3 from porcine brain cytosol and its characterization as a GTP‐binding protein highly homologous to the rho gene product

1989 • 139 citations

Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors.

1986 • 136 citations

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor

1990 • 136 citations

ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1.

1988 • 126 citations

Purification, cDNA‐cloning and expression of human diacylglycerol kinase

1990 • 124 citations

Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells.

1993 • 123 citations

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

1992 • 116 citations

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.

1992 • 107 citations

Clostridium botulinum C3 ADP-ribosyltransferase gene. Cloning, sequencing, and expression of a functional protein in Escherichia coli.

1991 • 102 citations

Insulin-induced formation of ruffling membranes of KB cells and its correlation with enhancement of amino acid transport.

1984 • 90 citations

Consequences of weak interaction of rho GDI with the GTP-bound forms of rho p21 and rac p21.

1993 • 75 citations

Tyrosine Phosphorylation of Phospholipase Cγ in c-met/HGF Receptor-Stimulated Hepatocytes: Comparison with HepG2 Hepatocarcinoma Cells

1993 • 55 citations

Requirement for receptor-intrinsic tyrosine kinase activities during ligand-induced membrane ruffling of KB cells. Essential sites of src-related growth factor receptor kinases.

1988 • 48 citations

Growth factor- and phorbol ester-induced changes in cell morphology analyzed by digital image processing*1

1988 • 30 citations