The Use of Computers in Understanding How Animal Cells Crawl

Principles of mathematical analysis

1964 • 5,515 citations

THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES

1962 • 2,726 citations

Chemotaxis in Escherichia coli analysed by Three-dimensional Tracking

1972 • 2,129 citations

Applied numerical analysis

2005 • 1,947 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination

1987 • 984 citations

The locomotion of fibroblasts in culture

1971 • 955 citations

Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors.

1977 • 905 citations

Evidence for the formation of cell aggregates by chemotaxis in the development of the slime mold Dictyostelium discoideum

1947 • 827 citations

Molecules and Cell Movement

1977 • 767 citations

Antisense RNA Inactivation of Myosin Heavy Chain Gene Expression in Dictyostelium discoideum

1987 • 677 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Change in direction of flagellar rotation is the basis of the chemotactic response in Escherichia coli

1974 • 462 citations

Life at the Leading Edge: The Formation of Cell Protrusions

1993 • 442 citations

Adenosine 3′,5′-Monophosphate Waves in Dictyostelium discoideum : a Demonstration by Isotope Dilution—Fluorography

1981 • 393 citations

The locomotion of fibroblasts in culture I. Movements of the leading edge

1970 • 389 citations

Photobiology of microorganisms

1970 • 371 citations

Dictyostelium discoideum : a Model System for Cell-Cell Interactions in Development

1989 • 342 citations

Temporal Stimulation of Chemotaxis in Escherichia coli

1974 • 334 citations

Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain

1988 • 326 citations

Numerical Analysis : A Practical Approach

1982 • 320 citations

Gene replacement in Dictyostelium: generation of myosin null mutants.

1989 • 299 citations

Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements

1989 • 281 citations

Capping of surface receptors and concomitant cortical tension are generated by conventional myosin

1989 • 274 citations

In pursuit of myosin function.

1989 • 252 citations

Reversible cyclic AMP-dependent change in distribution of myosin thick filaments in Dictyostelium

1985 • 250 citations

Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and cell motility.

1993 • 249 citations

Developmentally Regulated, Carbohydrate-Binding Protein in Dictyostelium discoideum

1973 • 246 citations

Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development

1994 • 233 citations

Biochemistry of Sensing and Adaptation in a Simple Bacterial System

1981 • 226 citations

Quantitative analysis of cell motility and chemotaxis in Dictyostelium discoideum by using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients.

1989 • 205 citations

International Cell Biology 1980–1981.

1982 • 204 citations

The bases of the locomotory behaviour of fibroblasts

1961 • 196 citations

CHEMOTAXIS IN LEUKOCYTES

1946 • 195 citations

Cell communication by periodic cyclic-AMP pulses

1975 • 187 citations

Chemotactic reorientation of granulocytes stimulated with micropipettes containing fmet-leu-phe

1981 • 187 citations

Caenorhabditis elegans spermatozoan locomotion: amoeboid movement with almost no actin.

1982 • 159 citations

A DESCRIPTIVE STUDY OF THE DEVELOPMENT OF THE SLIME MOLD DICTYOSTELIUM DISCOIDEUM

1944 • 158 citations

Visualization of actin fibers associated with the cell membrane in amoebae of Dictyostelium discoideum.

1975 • 151 citations

The unconventional myosin encoded by the myoA gene plays a role in Dictyostelium motility.

1993 • 148 citations

Myosin IB null mutants of Dictyostelium exhibit abnormalities in motility

1991 • 143 citations

Computer Graphics and Geometric Modeling Using Beta-splines

2013 • 140 citations

Generation and characterization of Dictyostelium cells deficient in a myosin I heavy chain isoform.

1990 • 137 citations

The Dictyostelium gelation factor shares a putative actin binding site with alpha-actinins and dystrophin and also has a rod domain containing six 100-residue motifs that appear to have a cross-beta conformation.

1989 • 132 citations

Cell behavior in Dictyostelium discoideum: preaggregation response to localized cyclic AMP pulses.

1982 • 129 citations

International cell biology 1980–1981

1982 • 128 citations

Targeted disruption of the ABP-120 gene leads to cells with altered motility.

1992 • 125 citations

Motility of cultured fish epidermal cells in the presence and absence of direct current electric fields.

1986 • 121 citations

Lymphocyte Locomotion and Migration

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A Dictyostelium mutant lacking an F-actin cross-linking protein, the 120-kD gelation factor.

1990 • 108 citations

Properties of the 120,000- and 95,000-dalton actin-binding proteins from Dictyostelium discoideum and their possible functions in assembling the cytoplasmic matrix.

1984 • 107 citations

Cell aggregation in Dictyostelium discoideum

1961 • 103 citations

In vivo, real‐time confocal imaging

1991 • 98 citations

Three‐dimensional dynamics of pseudopod formation and the regulation of turning during the motility cycle of Dictyostelium

1994 • 98 citations

Effects of cAMP on single cell motility in Dictyostelium.

1984 • 97 citations

Identification of a short sequence essential for actin binding by Dictyostelium ABP-120.

1990 • 93 citations

F-actin binds to the cytoplasmic surface of ponticulin, a 17-kD integral glycoprotein from Dictyostelium discoideum plasma membranes.

1987 • 93 citations

Preferential attachment of membrane glycoproteins to the cytoskeleton at the leading edge of lamella.

1991 • 90 citations

A Descriptive Study of the Development of the Slime Mold Dictyostelium discoideum

1944 • 85 citations

Frequency and orientation of pseudopod formation of Dictyostelium discoideum amebae chemotaxing in a spatial gradient: Further evidence for a temporal mechanism

1987 • 84 citations

Mechanisms of amoeboid chemotaxis: An evaluation of the cortical expansion model

1990 • 82 citations

Dictyostelium amebae alter motility differently in response to increasing versus decreasing temporal gradients of cAMP.

1985 • 81 citations

Genetic Approaches to Molecular Motors

1992 • 80 citations

“Dynamic morphology system”: A method for quantitating changes in shape, pseudopod formation, and motion in normal and mutant amoebae of Dictyostelium discoideum

1988 • 79 citations

Behavior of Dictyostelium amoebae is regulated primarily by the temporal dynamic of the natural cAMP wave

1992 • 79 citations

Experimental and Theoretical Advances in Biological Pattern Formation

1993 • 78 citations

Mutants lacking myosin II cannot resist forces generated during multicellular morphogenesis

1995 • 74 citations

Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods.

1995 • 69 citations

Myosin II heavy chain null mutant of Dictyostelium exhibits defective intracellular particle movement.

1990 • 68 citations

Myosin I

1990 • 67 citations

“DMS,” a computer‐assisted system for quantitating motility, the dynamics of cytoplasmic flow, and pseudopod formation: Its application to Dictyostelium chemotaxis

1988 • 66 citations

Amebae of Dictyostelium discoideum respond to an increasing temporal gradient of the chemoattractant cAMP with a reduced frequency of turning: Evidence for a temporal mechanism in ameboid chemotaxis

1987 • 64 citations

Three‐dimensional motility cycle in leukocytes

1992 • 63 citations

Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium.

1994 • 56 citations

Chemoattractant‐elicited translocation of myosin in motile Dictyostelium

1989 • 52 citations

Signal transduction, chemotaxis, and cell aggregation in Dictyostelium discoideum cells without myosin heavy chain

1988 • 51 citations

Ponticulin is an atypical membrane protein.

1994 • 51 citations

HIV-induced syncytia of a T cell line form single giant pseudopods and are motile

1993 • 51 citations

3D Analysis of Cell Movement during Normal and Myosin-II-Null Cell Morphogenesis in Dictyostelium

1995 • 51 citations

Oscillations in cell shape and size during locomotion and in contractile activities of Physarum polycephalum, Dictyostelium discoideum, Amoeba proteus and macrophages

1985 • 49 citations

Discoidin proteins of Dictyostelium are necessary for normal cytoskeletal organization and cellular morphology during aggregation

1992 • 47 citations

Isolation of a new actin‐binding protein from dictyostelium discoideum

1982 • 43 citations

Motility.

1981 • 43 citations

Cell‐cell adhesion in Dictyostelium discoideum

1988 • 39 citations

In vitro induction of crawling in the amoeboid sperm of the nematode parasite, Ascaris suum

1990 • 37 citations

Theory for epithelial‐mesenchymal transformation based on the “fixed cortex” cell motility model

1989 • 37 citations

Patterns in Dictyostelium discoideum: the role of myosin II in the transition from the unicellular to the multicellular phase

1993 • 35 citations

Human neutrophil motility: Time‐dependent three‐dimensional shape and granule diffusion

1994 • 30 citations

Actin‐Associated proteins in Dictyostelium discoideum

1990 • 30 citations

Understanding the cortex of crawling cells: insights from Dictyostelium

1993 • 29 citations

Electron microscopic localization of myosin II and ABP‐120 in the cortical actin matrix of Dictyostelium amoebae using IgG‐gold conjugates

1988 • 29 citations

Microfilament-Membrane Interactions in Cell Shape and Surface Architecture

1981 • 28 citations

Genetic Alteration of Proteins in Actin-Based Motility Systems

1991 • 26 citations

Stopped-flow measurement of cytoskeletal contraction: Dictyostelium myosin II is specifically required for contraction of amoeba cytoskeletons.

1991 • 25 citations

Cell Behavior and Actomyosin Organization in Dictyostelium During Substrate Exploration.

1991 • 23 citations

Failure to detect immunocytochemically reactive endogenous lectin on the cell surface of Dictyostelium discoideum.

1983 • 23 citations

T cells and HIV-induced T cell syncytia exhibit the same motility cycle

1995 • 23 citations

Ponticulin, a developmentally‐regulated plasma membrane glycoprotein, mediates actin binding and nucleation

1990 • 22 citations

Ultrastructure and motion analysis of permeabilized paramecium capable of motility and regulation of motility

1988 • 20 citations

The Motile Behavior of Amoebae in the Aggregation Wave in Dictyostelium Discoideum

1993 • 18 citations

In ascaris sperm pseudopods, msp fibers move proximally at a constant rate regardless of the forward rate of cellular translocation

1995 • 17 citations

Behavioral responses of streamer F mutants of Dictyostelium discoideum: Effects of cyclic GMP on cell motility

1992 • 17 citations

Quantification of human sperm morphology and motility by means of semi-automatic image analysis systems.

1979 • 16 citations

Use of a Microcomputer in Combination with the Multiple Exposure Photography Technique for Human Sperm Motility Determination

1980 • 15 citations

The molecular basis of amoeboid movement.

1975 • 15 citations

Intracellular vesicle movement, cAMP and myosin II in Dictyostelium

1990 • 14 citations

Invasion by WC5 rat cerebellar cells is independent of RSV‐induced changes in growth and adhesion

1991 • 12 citations

Video analysis of chemotactic locomotion of stored human polymorphonuclear leukocytes

1986 • 12 citations

A Mutation That Depresses cGMP Phosphodiesterase Activity in Dictyostelium Affects Cell Motility through an Altered Chemotactic Signal

1995 • 11 citations

Invasion of rous sarcoma virus‐transformed retinal cells: Role of cell motility

1991 • 11 citations

Bacterial Motility: Handedness and Symmetry

2007 • 8 citations

Development And Application Of The "Dynamic Morphology System" For The Analysis Of Moving Amebae

1988 • 8 citations

Studies of mechanical aspects of amoeboid locomotion.

1993 • 7 citations

Bidirectional transcription from actin promoters in Dictyostelium

1993 • 6 citations

Reactivation of Tritonated Models of Human Polymorphonuclear Leukocytes (PMNs): A Computer-Assisted Analysis

1985 • 3 citations

Deleted Work

1955 • 0 citations