Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

A novel ras-related gene family

1985 • 487 citations

The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

1995 • 479 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

From signal to pseudopod

1989 • 460 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

Rab GTPases in vesicular transport

1993 • 379 citations

The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts.

1992 • 374 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

Actin-binding proteins

1991 • 289 citations

Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line

1990 • 285 citations

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

1994 • 283 citations

Modular organization of actin crosslinking proteins

1991 • 282 citations

Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators.

1990 • 270 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

Molecular Cloning of YPT1/SEC4-Related cDNAs from an Epithelial Cell Line

1990 • 210 citations

Fimbrin is a homologue of the cytoplasmic phosphoprotein plastin and has domains homologous with calmodulin and actin gelation proteins.

1990 • 208 citations

Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP.

1995 • 208 citations

Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.

1990 • 204 citations

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

1990 • 202 citations

Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets

1991 • 193 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.

1992 • 186 citations

Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.

1990 • 172 citations

Is there a relationship between phosphatidylinositol trisphosphate and F-actin polymerization in human neutrophils?

1990 • 153 citations

Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

1994 • 134 citations

A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.

1991 • 129 citations

The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach

1992 • 120 citations

Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

1992 • 114 citations

Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells

1993 • 107 citations

Functional differences between L- and T-plastin isoforms.

1994 • 97 citations

Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation

1993 • 84 citations

Abundant synthesis of the transformation-induced protein of neoplastic human fibroblasts, plastin, in normal lymphocytes.

1985 • 79 citations

Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1

1988 • 73 citations

Identification of the human platelet GTPase activating protein for the CDC42Hs protein.

1991 • 71 citations

Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain

1989 • 59 citations

Myosin at the apical pole of ciliated epithelial cells as revealed by a monoclonal antibody.

1986 • 58 citations

A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex

1993 • 52 citations

Specific protein phosphorylation in human promyelocytic HL-60 leukemia cells susceptible or resistant to induction of cell differentiation by phorbol-12-myristate-13-acetate.

1985 • 44 citations

Thiol- and pH-modulated slow conformational changes and cooperativity of phenol-binding sites in phenol hydroxylase

1988 • 9 citations