Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers

Functional rafts in cell membranes

1997 • 9,471 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

2002 • 2,231 citations

Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension

2003 • 1,555 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Lipid Rafts

2003 • 1,485 citations

The dynamin superfamily: universal membrane tubulation and fission molecules?

2004 • 1,329 citations

Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER

2001 • 1,236 citations

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

2003 • 1,115 citations

Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains

1996 • 1,006 citations

Extraction of Cholesterol with Methyl-β-Cyclodextrin Perturbs Formation of Clathrin-coated Endocytic Vesicles

1999 • 970 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes

2004 • 865 citations

Clathrin-independent endocytosis of ubiquitinated cargos

2005 • 818 citations

THE FINE STRUCTURE OF THE GALL BLADDER EPITHELIUM OF THE MOUSE

1955 • 791 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Regulated internalization of caveolae.

1994 • 760 citations

Dynamin-mediated Internalization of Caveolae

1998 • 750 citations

A detergent-free method for purifying caveolae membrane from tissue culture cells.

1995 • 732 citations

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

2003 • 728 citations

Filipin-dependent Inhibition of Cholera Toxin: Evidence for Toxin Internalization and Activation through Caveolae-like Domains

1998 • 724 citations

Caveolae/raft-dependent endocytosis

2003 • 722 citations

Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae

2002 • 715 citations

Mutations in human dynamin block an intermediate stage in coated vesicle formation

1993 • 702 citations

Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits

2002 • 695 citations

A Pathway for Association of Receptors, Adaptors, and Actin during Endocytic Internalization

2003 • 682 citations

Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles.

1976 • 663 citations

Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium

1998 • 657 citations

GPI-Anchored Proteins Are Delivered to Recycling Endosomes via a Distinct cdc42-Regulated, Clathrin-Independent Pinocytic Pathway

2002 • 647 citations

De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

1995 • 597 citations

Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms

2003 • 589 citations

Actin Assembly and Endocytosis: From Yeast to Mammals

2003 • 582 citations

Acute cholesterol depletion inhibits clathrin-coated pit budding

1999 • 576 citations

Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

1999 • 562 citations

Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast

2000 • 550 citations

Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.

1990 • 533 citations

Integrins Regulate Rac Targeting by Internalization of Membrane Domains

2004 • 533 citations

Effect of the Structure of Natural Sterols and Sphingolipids on the Formation of Ordered Sphingolipid/Sterol Domains (Rafts)

2001 • 523 citations

Interleukin 2 Receptors and Detergent-Resistant Membrane Domains Define a Clathrin-Independent Endocytic Pathway

2001 • 513 citations

Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae.

1994 • 506 citations

Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process

2003 • 478 citations

Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin

2003 • 475 citations

VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro.

1995 • 465 citations

Caveolae and sorting in the trans-Golgi network of epithelial cells.

1993 • 461 citations

Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule Abnormalities

2001 • 450 citations

Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae.

1994 • 449 citations

The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase

2002 • 448 citations

Clathrin- and caveolin-1–independent endocytosis

2005 • 443 citations

Developmental Control of Endocytosis in Dendritic Cells by Cdc42

2000 • 440 citations

A Dynamic Actin Cytoskeleton Functions at Multiple Stages of Clathrin-mediated Endocytosis

2004 • 433 citations

Caveolae Are Highly Immobile Plasma Membrane Microdomains, Which Are not Involved in Constitutive Endocytic Trafficking

2002 • 431 citations

Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles

2005 • 431 citations

The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast

1998 • 416 citations

Sterol structure determines the separation of phases and the curvature of the liquid-ordered phase in model membranes

2005 • 404 citations

Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin.

1995 • 400 citations

Regulation of receptor-mediated endocytosis by Rho and Rac

1996 • 386 citations

Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae.

1996 • 384 citations

Internalization of cholera toxin by different endocytic mechanisms

2001 • 383 citations

end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

1993 • 380 citations

Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane.

1994 • 370 citations

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

2001 • 357 citations

Drs2p-related P-type ATPases Dnf1p and Dnf2p Are Required for Phospholipid Translocation across the Yeast Plasma Membrane and Serve a Role in Endocytosis

2003 • 353 citations

EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake

1999 • 347 citations

Domain-induced budding of vesicles

1993 • 344 citations

Clathrin-dependent and -independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathways

2001 • 319 citations

A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance

2001 • 313 citations

end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae.

1995 • 305 citations

When ubiquitin meets ubiquitin receptors: a signalling connection

2003 • 303 citations

Characterization of a Nonclathrin Endocytic Pathway: Membrane Cargo and Lipid Requirements

2004 • 294 citations

Regulation of Macropinocytosis by p21-activated Kinase-1

2000 • 293 citations

Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains

1998 • 291 citations

Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway

2000 • 289 citations

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ

2003 • 278 citations

Cytoplasmic Tail Phosphorylation of the α-Factor Receptor Is Required for Its Ubiquitination and Internalization

1998 • 276 citations

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

1999 • 275 citations

A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting

1990 • 274 citations

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

1993 • 272 citations

Convergence of Non-clathrin- and Clathrin-derived Endosomes Involves Arf6 Inactivation and Changes in Phosphoinositides

2003 • 272 citations

Membrane ruffling and macropinocytosis in A431 cells require cholesterol

2002 • 269 citations

Selective Stimulation of Caveolar Endocytosis by Glycosphingolipids and Cholesterol

2004 • 265 citations

The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.

1994 • 260 citations

An Essential Subfamily of Drs2p-related P-Type ATPases Is Required for Protein Trafficking between Golgi Complex and Endosomal/Vacuolar System

2002 • 259 citations

A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complex

2002 • 259 citations

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling

1999 • 259 citations

Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.

1994 • 258 citations

Selective Caveolin-1–dependent Endocytosis of Glycosphingolipids

2003 • 251 citations

Clathrin-mediated endocytosis is essential in Trypanosoma brucei

2003 • 248 citations

Secretory Pathway of Trypanosomatid Parasites

2002 • 247 citations

Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae

2000 • 241 citations

Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase.

1996 • 237 citations

Caveolin-1 Is a Negative Regulator of Caveolae-mediated Endocytosis to the Endoplasmic Reticulum

2002 • 235 citations

Neural Wiskott Aldrich Syndrome Protein (N-WASP) and the Arp2/3 complex are recruited to sites of clathrin-mediated endocytosis in cultured fibroblasts

2004 • 230 citations

Pan1p, Yeast eps15, Functions as a Multivalent Adaptor That Coordinates Protein–Protein Interactions Essential for Endocytosis

1998 • 220 citations

An Actin-Binding Protein of the Sla2/Huntingtin Interacting Protein 1 Family Is a Novel Component of Clathrin-Coated Pits and Vesicles

1999 • 217 citations

Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein inTrypanosoma brucei

2004 • 214 citations

Role of Src-induced Dynamin-2 Phosphorylation in Caveolae-mediated Endocytosis in Endothelial Cells

2004 • 211 citations

Ligand-dependent and -independent Transforming Growth Factor-β Receptor Recycling Regulated by Clathrin-mediated Endocytosis and Rab11

2004 • 206 citations

Ganglioside Structure Dictates Signal Transduction by Cholera Toxin and Association with Caveolae-like Membrane Domains in Polarized Epithelia

1998 • 206 citations

Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum

2003 • 202 citations

The VPS1 protein, a homolog of dynamin required for vacuolar protein sorting in Saccharomyces cerevisiae, is a GTPase with two functionally separable domains.

1992 • 202 citations

Cortactin Is a Component of Clathrin-Coated Pits and Participates in Receptor-Mediated Endocytosis

2003 • 201 citations

Protein Uptake and Digestion in Bloodstream and Culture Forms of Trypanosoma brucei*

1975 • 193 citations

Lipid rafts and plasma membrane microorganization: insights from Ras

2004 • 187 citations

Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane.

1995 • 183 citations

Live cell imaging of the assembly, disassembly, and actin cable–dependent movement of endosomes and actin patches in the budding yeast, Saccharomyces cerevisiae

2004 • 180 citations

Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast

2001 • 180 citations

Down regulation of the α-factor pheromone receptor in S. cerevisiae

1986 • 177 citations

The Yeast Dynamin-like Protein, Mgm1p, Functions on the Mitochondrial Outer Membrane to Mediate Mitochondrial Inheritance

1999 • 176 citations

Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo

2001 • 175 citations

Multiple Functions of Sterols in Yeast Endocytosis

2002 • 175 citations

The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane

1991 • 173 citations

CtBP3/BARS drives membrane fission in dynamin-independent transport pathways

2005 • 170 citations

Adaptor Complex-independent Clathrin Function in Yeast

1999 • 167 citations

Specific Sterols Required for the Internalization Step of Endocytosis in Yeast

1999 • 166 citations

The WASp homologue Las17p functions with the WIP homologue End5p/verprolin and is essential for endocytosis in yeast

1998 • 161 citations

Control of Vesicular Trafficking by Rho GTPases

2003 • 160 citations

A differential role for actin during the life cycle of Trypanosoma brucei

2004 • 157 citations

Signal Propagation and Regulation in the Mating Pheromone Response Pathway of the Yeast Saccharomyces cerevisiae

1994 • 157 citations

Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast.

1988 • 153 citations

Endocytosis, membrane recycling and sorting of GPI‐anchored proteins: Trypanosoma brucei as a model system

2004 • 148 citations

The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin

2005 • 146 citations

Caveolins and Cellular Cholesterol Balance

2000 • 145 citations

Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast

1999 • 143 citations

Regulated Internalization and Phosphorylation of the Native Norepinephrine Transporter in Response to Phorbol Esters

2004 • 142 citations

Molecular requirements for the internalisation step of endocytosis: insights from yeast

2001 • 137 citations

Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway

2004 • 137 citations

A Role for Caveolae/Lipid Rafts in the Uptake and Recycling of the Endogenous Cannabinoid Anandamide

2004 • 133 citations

Cortactin and dynamin are required for the clathrin-independent endocytosis of γc cytokine receptor

2004 • 132 citations

Expression of Mutant Dynamin Inhibits Toxicity and Transport of Endocytosed Ricin to the Golgi Apparatus

1998 • 123 citations

Tyrosine-phosphorylated Caveolin-1: Immunolocalization and Molecular Characterization

1999 • 123 citations

Endocytosis of Oxidized Low Density Lipoprotein through Scavenger Receptor CD36 Utilizes a Lipid Raft Pathway That Does Not Require Caveolin-1

2003 • 122 citations

Agonist-induced redistribution of bradykinin B 2 receptor in caveolae

1998 • 116 citations

Akr1p and the Type I Casein Kinases Act prior to the Ubiquitination Step of Yeast Endocytosis: Akr1p Is Required for Kinase Localization to the Plasma Membrane

2000 • 113 citations

Induction of Caveolae in the Apical Plasma Membrane of Madin-Darby Canine Kidney Cells

1999 • 113 citations

Dynamin and clathrin are required for the biogenesis of a distinct class of secretory vesicles in yeast

2002 • 109 citations

Developmental and morphological regulation of clathrin-mediated endocytosis inTrypanosoma brucei

2001 • 105 citations

v-Src induces constitutive macropinocytosis in rat fibroblasts

1996 • 100 citations

Gβγ Activation of Src Induces Caveolae-mediated Endocytosis in Endothelial Cells

2004 • 100 citations

Intersectin Regulates Fission and Internalization of Caveolae in Endothelial Cells

2003 • 98 citations

Actin-, myosin- and ubiquitin-dependent endocytosis

1996 • 94 citations

From rafts to crafts: membrane asymmetry in moving cells

2003 • 91 citations

shibiremutations reveal distinct dynamin-independent and-dependent endocytic pathways in primary cultures ofDrosophilahemocytes

2003 • 88 citations

Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits

2005 • 88 citations

Involvement of Caveolin in Ligand-Induced Recruitment and Internalization of A₁Adenosine Receptor and Adenosine Deaminase in an Epithelial Cell Line

2001 • 87 citations

The Cdc42 Target ACK2 Directly Interacts with Clathrin and Influences Clathrin Assembly

2001 • 80 citations

The Single Dynamin-like Protein of Trypanosoma brucei Regulates Mitochondrial Division and Is Not Required for Endocytosis

2004 • 80 citations

A Novel GTPase-activating Protein for ARF6 Directly Interacts with Clathrin and Regulates Clathrin-dependent Endocytosis

2005 • 80 citations

The Light Chain Subunit Is Required for Clathrin Function in Saccharomyces cerevisiae

1996 • 77 citations

Visualization of Receptor-mediated Endocytosis in Yeast

1999 • 77 citations

Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoparan and cAMP

1994 • 75 citations

Endocytosis by African trypanosomes. I. Three-dimensional structure of the endocytic organelles in Trypanosoma brucei and T. congolense.

1989 • 71 citations

The yeast dynamin-related GTPase Vps1p functions in the organization of the actin cytoskeleton via interaction with Sla1p

2004 • 67 citations

Intracellular Membrane Transport Systems in Trypanosoma brucei

2004 • 65 citations

Rvs161p and Rvs167p, the Two Yeast Amphiphysin Homologs, Function Together in Vivo

2001 • 60 citations

Agonist-promoted trafficking of human bradykinin receptors: arrestin- and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells

2001 • 58 citations

Biogenesis of Cell-surface Polarity in Epithelial Cells and Neurons

1992 • 58 citations

Antibodies to Clathrin Inhibit Endocytosis But Not Recycling to the Trans Golgi Network in Vitro

1990 • 58 citations

Human B1 and B2 Bradykinin Receptors and Their Agonists Target Caveolae-Related Lipid Rafts to Different Degrees in HEK293 Cells

2002 • 57 citations

Phorbol Myristate Acetate Selectively Stimulates Apical Endocytosis via Protein Kinase C in Polarized MDCK Cells

1995 • 54 citations

Raft Partitioning of the Yeast Uracil Permease During Trafficking Along the Endocytic Pathway

2003 • 54 citations

Plasma membrane localization of the Yck2p yeast casein kinase 1 isoform requires the C-terminal extension and secretory pathway function

2002 • 52 citations

Lipid Raft-dependent Glucagon-like Peptide-2 Receptor Trafficking Occurs Independently of Agonist-induced Desensitization

2004 • 48 citations

Functional Interactions between the p35 Subunit of the Arp2/3 Complex and Calmodulin in Yeast

2000 • 44 citations

Kinases in clathrin-mediated endocytosis

2003 • 32 citations

Apical endocytosis of ricin in MDCK cells is regulated by the cyclooxygenase pathway

2000 • 28 citations

Clathrin Interactions with C‐Terminal Regions of the Yeast AP‐1 β and γ Subunits are Important for AP‐1 Association with Clathrin Coats

2001 • 26 citations