A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Methods in yeast genetics

1979 • 7,824 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Methods in Yeast Genetics

1988 • 4,905 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.

1987 • 2,266 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Rapid similarity searches of nucleic acid and protein data banks.

1983 • 1,577 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase

1982 • 1,539 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

Transformation of yeast by a replicating hybrid plasmid

1978 • 1,362 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

A ras-like protein is required for a post-Golgi event in yeast secretion

1987 • 894 citations

Order of events in the yeast secretory pathway

1981 • 804 citations

An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences

1982 • 801 citations

Multiple Mechanisms of Protein Insertion into and Across Membranes

1985 • 720 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

Reconstitution of the transport of protein between successive compartments of the golgi measured by the coupled incorporation of N-acetylglucosamine

1984 • 689 citations

GTP-binding domain: three consensus sequence elements with distinct spacing.

1987 • 602 citations

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1988 • 592 citations

Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole

1982 • 579 citations

A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast

1989 • 570 citations

Do GTPases direct membrane traffic in secretion?

1988 • 540 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

Phenotypic analysis of temperature-sensitive yeast actin mutants

1985 • 512 citations

Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane

1986 • 509 citations

Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene.

1980 • 502 citations

Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus

1986 • 479 citations

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

1989 • 474 citations

[3] Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance

1989 • 455 citations

A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus.

1989 • 443 citations

Protein sorting in yeast: Mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway

1986 • 429 citations

Organelle assembly in yeast: characterization of yeast mutants defective in vacuolar biogenesis and protein sorting.

1988 • 409 citations

Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein

1990 • 401 citations

Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

1985 • 396 citations

A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product

1983 • 396 citations

Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack

1988 • 389 citations

Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP–binding domains

1989 • 357 citations

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

1986 • 341 citations

Reconstitution of SEC gene product-dependent intercompartmental protein transport

1988 • 332 citations

Semi-intact cells permeable to macromolecules: Use in reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex

1987 • 321 citations

cDNA structures and regulation of two interferon-induced human Mx proteins.

1989 • 300 citations

The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide

1989 • 293 citations

Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae.

1989 • 258 citations

Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus.

1983 • 247 citations

The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae.

1988 • 174 citations

Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product

1985 • 159 citations

Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene.

1986 • 151 citations

Topology of signal recognition particle receptor in endoplasmic reticulum membrane

1985 • 140 citations

Yeast Sec23p acts in the cytoplasm to promote protein transport from the endoplasmic reticulum to the Golgi complex in vivo and in vitro.

1989 • 128 citations

Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses

1985 • 123 citations

Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter

1990 • 116 citations

A double-stranded RNA-inducible fish gene homologous to the murine influenza virus resistance gene Mx.

1989 • 92 citations

Interferon-induced Mx protein: a mediator of cellular resistance to influenza virus.

1987 • 87 citations

Identification of a Second Interferon-Regulated Murine Mx Gene

1988 • 87 citations

Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins.

1988 • 86 citations

A family of interferon-induced Mx-related mRNAs encodes cytoplasmic and nuclear proteins in rat cells

1988 • 84 citations

Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae.

1984 • 82 citations

Protein targeting to the yeast vacuole

1989 • 81 citations

Identification of a second interferon-regulated murine Mx gene.

1988 • 58 citations

Protein transfer and organelle biogenesis

1989 • 53 citations

Combined action of mouse alpha and beta interferons in influenza virus-infected macrophages carrying the resistance gene Mx

1984 • 49 citations

The action of recombinant bovine interferons on influenza virus replication correlates with the induction of two Mx-related proteins in bovine cells

1988 • 32 citations

GTP and methionine bristles

1989 • 30 citations

Protein Sorting and Biogenesis of the Lysosome-like Vacuole in Yeast

1988 • 6 citations