Actin-, myosin- and ubiquitin-dependent endocytosis

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast.

1995 • 1,352 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1995 • 816 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Regulated internalization of caveolae.

1994 • 760 citations

Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals

1995 • 760 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Macropinocytosis

1995 • 706 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.

1990 • 533 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

1990 • 443 citations

Life at the Leading Edge: The Formation of Cell Protrusions

1993 • 442 citations

Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells.

1993 • 438 citations

A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.

1996 • 408 citations

VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.

1995 • 393 citations

end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

1993 • 380 citations

Coronin involved in phagocytosis: Dynamics of particle-induced relocalization visualized by a green fluorescent protein tag

1995 • 353 citations

Actin and fimbrin are required for the internalization step of endocytosis in yeast.

1993 • 346 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

Myosin I is located at the leading edges of locomoting Dictyostelium amoebae

1989 • 323 citations

Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality.

1990 • 320 citations

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

1994 • 319 citations

The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain

1988 • 317 citations

Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease

1996 • 316 citations

Role of coated vesicles, microfilaments, and calmodulin in receptor-mediated endocytosis by cultured B lymphoblastoid cells.

1980 • 315 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae.

1995 • 305 citations

A role for MARCKS, the alpha isozyme of protein kinase C and myosin I in zymosan phagocytosis by macrophages.

1995 • 303 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae

1993 • 289 citations

The emergence of clathrin-independent pinocytic pathways

1995 • 282 citations

Endocytosis in yeast: Several of the yeast secretory mutants are defective in endocytosis

1985 • 280 citations

Endocytosis and degradation of the yeast uracil permease under adverse conditions

1994 • 266 citations

Role of Type I Myosins in Receptor-Mediated Endocytosis in Yeast

1996 • 263 citations

The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.

1994 • 260 citations

Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae.

1989 • 258 citations

Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes.

1994 • 258 citations

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors

1993 • 239 citations

Endocytosis in yeast: Evidence for the involvement of a small GTP-binding protein (Ypt7p)

1992 • 235 citations

Regulation and function of the Rho subfamily of small GTPases

1994 • 233 citations

The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium.

1995 • 213 citations

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

1995 • 213 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

Binding of α-factor pheromone to yeast a cells: Chemical and genetic evidence for an α-factor receptor

1983 • 211 citations

Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast.

1994 • 211 citations

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages.

1993 • 201 citations

Dictyostelium myosin I double mutants exhibit conditional defects in pinocytosis.

1995 • 198 citations

Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae

1994 • 184 citations

The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2.

1995 • 183 citations

Down regulation of the α-factor pheromone receptor in S. cerevisiae

1986 • 177 citations

Endocytosis: what goes in and how?

1992 • 177 citations

Dictyostelium mutants lacking multiple classic myosin I isoforms reveal combinations of shared and distinct functions.

1996 • 176 citations

Ca(2+)-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages.

1991 • 175 citations

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.

1992 • 173 citations

Alteration of a yeast SH3 protein leads to conditional viability with defects in cytoskeletal and budding patterns.

1993 • 172 citations

Two yeast mutants defective in endocytosis are defective in pheromone response

1986 • 164 citations

Signal Propagation and Regulation in the Mating Pheromone Response Pathway of the Yeast Saccharomyces cerevisiae

1994 • 157 citations

Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.

1994 • 157 citations

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.

1993 • 155 citations

Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast.

1988 • 153 citations

Clathrin facilitates the internalization of seven transmembrane segment receptors for mating pheromones in yeast.

1993 • 151 citations

Involvement of Ypt7p, a small GTPase, in traffic from late endosome to the vacuole in yeast

1993 • 150 citations

The unconventional myosin encoded by the myoA gene plays a role in Dictyostelium motility.

1993 • 148 citations

Autoimmunity in Stiff‐Man Syndrome with breast cancer is targeted to the C‐terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161

1994 • 144 citations

Myosin IB null mutants of Dictyostelium exhibit abnormalities in motility

1991 • 143 citations

A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.

1995 • 142 citations

Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.

1994 • 142 citations

Actin cytoskeleton and budding pattern are altered in the yeast rvs161 mutant: the Rvs161 protein shares common domains with the brain protein amphiphysin

1995 • 138 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

Inhibition of apical but not basolateral endocytosis of ricin and folate in Caco-2 cells by cytochalasin D

1994 • 130 citations

Endocytosis and Vacuolar Degradation of the Plasma Membrane-Localized Pdr5 ATP-Binding Cassette Multidrug Transporter in Saccharomyces cerevisiae

1995 • 129 citations

Characterization of VPS34, a Gene Required for Vacuolar Protein Sorting and Vacuole Segregation in Saccharomyces cerevisiae†

1990 • 126 citations

Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.

1993 • 126 citations

Clathrin heavy chain is required for pinocytosis, the presence of large vacuoles, and development in Dictyostelium.

1992 • 126 citations

DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast.

1995 • 126 citations

The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole

1996 • 124 citations

Partial purification and characterization of early and late endosomes from yeast. Identification of four novel proteins

1993 • 120 citations

Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.

1993 • 119 citations

Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells

1994 • 119 citations

Detection of an intermediate compartment involved in transport of alpha-factor from the plasma membrane to the vacuole in yeast.

1990 • 111 citations

Transport through the yeast endocytic pathway occurs through morphologically distinct compartments and requires an active secretory pathway and Sec18p/N-ethylmaleimide-sensitive fusion protein.

1997 • 108 citations

Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae.

1994 • 102 citations

A proline‐rich protein, verprolin, involved in cytoskeletal organization and cellular growth in the yeast Saccharomyces cerevisiae

1993 • 95 citations

Calcium-independent calmodulin requirement for endocytosis in yeast.

1994 • 82 citations

Identification and molecular characterization of a yeast myosin I

1995 • 82 citations

Yeast ypt51p and mammalian rab5: Counterparts with similar function in the early endocytic pathway

1995 • 80 citations

Yeast clathrin has a distinctive light chain that is important for cell growth.

1990 • 80 citations

Regulation of Inositol Transport in Saccharomyces cerevisiae Involves Inositol-induced Changes in Permease Stability and Endocytic Degradation in the Vacuole

1995 • 78 citations

Molecular motors, membrane movements and physiology: emerging roles for myosins

1995 • 76 citations

Alteration of a Yeast SH3 Protein Leads to Conditional Viability with Defects in Cytoskeletal and Budding Patterns

1993 • 60 citations

Quantification and localization of phosphorylated myosin I isoforms in Acanthamoeba castellanii.

1995 • 59 citations

Direct Evidence for Ligand-Induced Internalization of the Yeast α-Factor Pheromone Receptor

1994 • 57 citations

Differential localization of α‐actinin and the 30 kD actin‐bundling protein in the cleavage furrow, phagocytic cup, and contractile vacuole of Dictyostelium discoideum

1994 • 55 citations

Dictyostelium discoideum mutants with conditional defects in phagocytosis.

1994 • 40 citations

The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast

1995 • 37 citations

Endocytosis without clathrin A minireview

1991 • 33 citations

Dictyostelium discoideum mutants with temperature-sensitive defects in endocytosis.

1994 • 22 citations

Novel proteins mediate an interaction between clathrin‐coated vesicles and polymerizing actin filaments

1990 • 14 citations

Endocytosis and intracellular transport of protein toxins

1993 • 14 citations

Three clathrin-dependent budding steps and cell polarity

1993 • 13 citations

Involvement of endocytosis in catabolite inactivation of the transport systems inSaccharomyces cerevisiae

1994 • 2 citations