The transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers.

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

1991 • 760 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

1994 • 737 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm

1992 • 486 citations

Inhibition of activin receptor signaling promotes neuralization in Xenopus

1994 • 484 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development

1989 • 418 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis

1991 • 373 citations

Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells

1994 • 368 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm

1993 • 365 citations

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.

1993 • 354 citations

FGF signalling in the early specification of mesoderm in Xenopus

1993 • 319 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase

1990 • 293 citations

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct

1994 • 290 citations

Regional specification within the mesoderm of early embryos of Xenopus laevis

1987 • 286 citations

Dorsalization and neural induction: properties of the organizer in Xenopus laevis.

1983 • 267 citations

Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor

1994 • 254 citations

Inducing factors in Xenopus early embryos

1994 • 234 citations

Mesoderm induction by activin requires FGF-mediated intracellular signals

1994 • 225 citations

Retinoic acid modifies mesodermal patterning in early Xenopus embryos.

1991 • 221 citations

Activin-mediated mesoderm induction requires FGF

1994 • 208 citations

Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin

1991 • 194 citations

Bone morphogenetic protein 4 (BMP-4), a member of the TGF-β family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity

1991 • 167 citations

Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor‐β type II receptor family

1993 • 164 citations

Xwnt-8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm.

1992 • 155 citations

Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?

1994 • 145 citations

Cell lineage and the induction of second nervous systems in amphibian development

1983 • 135 citations

Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: the role of maternal activin.

1994 • 109 citations

ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin

1992 • 105 citations

The anterior extent of dorsal development of the Xenopus embryonic axis depends on the quantity of organizer in the late blastula

1990 • 102 citations

Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus

1992 • 89 citations

Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern

1994 • 78 citations

Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern

1994 • 72 citations

The midblastula cell cycle transition and the character of mesoderm in u.v.-induced nonaxialXenopusdevelopment

1987 • 65 citations

Regulation of Primary Erythropoiesis in the Ventral Mesoderm of Xenopus Gastrula Embryo: Evidence for the Expression of a Stimulatory Factor(s) in Animal Pole Tissue

1994 • 54 citations

An Inhibitory Effect of Xenopus Gastrula Ectoderm on Muscle Cell Differentiation and Its Role for Dorsoventral Patterning of Mesoderm

1994 • 16 citations