The Majority of Stem Cell Factor Exists as Monomer under Physiological Conditions

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Computed circular dichroism spectra for the evaluation of protein conformation

1969 • 3,654 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Current protocols in immunology

1992 • 1,464 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

PCR Technology: Principles and Applications for DNA Amplification

1989 • 689 citations

The kit Ligand, Stem Cell Factor

1993 • 653 citations

PCR Technology: Principles and Applications for DNA Amplification

1990 • 512 citations

Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis.

1991 • 333 citations

Binding of plasma fibronectin to cell layers of human skin fibroblasts.

1983 • 289 citations

Platelet-derived growth factor: Identification of constituent polypeptide chains

1982 • 275 citations

Structure-function studies of a colony stimulating factor (CSF-1).

1982 • 175 citations

Three-Dimensional Structure of Dimeric Human Recombinant Macrophage Colony-Stimulating Factor

1992 • 174 citations

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

1995 • 160 citations

Soluble stem cell factor in human serum

1993 • 151 citations

Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.

1992 • 151 citations

Steel Factor and c-kit Protooncogene: Genetic Lessons in Signal Transduction

1994 • 116 citations

Glycosylated and unglycosylated recombinant-derived human stem cell factors are dimeric and have extensive regular secondary structure.

1991 • 110 citations

Interspecies molecular chimeras of kit help define the binding site of the stem cell factor.

1993 • 81 citations

Amino acid sequence and post-translational modification of stem cell factor isolated from buffalo rat liver cell-conditioned medium

1991 • 80 citations

Soluble kit receptor in human serum

1995 • 73 citations

Human Stem Cell Factor Dimer Forms a Complex with Two Molecules of the Extracellular Domain of Its Receptor, Kit

1996 • 71 citations

Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand

1996 • 68 citations

Identification and characterization of a soluble c-kit receptor produced by human hematopoietic cell lines

1995 • 67 citations

Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors.

1994 • 61 citations

A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses.

1992 • 57 citations

Purification and characterization of soluble forms of human and rat stem cell factor recombinantly expressed by Escherichia coli and by Chinese hamster ovary cells

1992 • 53 citations

Assignment of the inter- and intramolecular disulfide linkages in recombinant human macrophage colony stimulating factor using fast atom bombardment mass spectrometry

1993 • 51 citations

In vitro methionine oxidation of escherichia coli‐derived human stem cell factor: Effects on the molecular structure, biological activity, and dimerization

1996 • 51 citations

Properties of Variant Forms of Human Stem Cell Factor Recombinantly Expressed in Escherichia coli

1994 • 50 citations

Protein Tyrosine Kinase Growth Factor Receptors and their Ligands in Development, Differentiation, and Cancer

1992 • 49 citations

8 Some Physical Probes of Enzyme Structure in Solution

1970 • 29 citations

Spontaneous dissociation-association of monomers of the human-stem-cell-factor dimer

1995 • 26 citations