Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Epidermal Growth Factor

1979 • 2,964 citations

Epidermal growth factor.

1990 • 1,645 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Cloning and sequence analysis of a cDNA for rat transforming growth factor-α

1985 • 388 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

Induction of transforming growth factor-α in activated human alveolar macrophages

1988 • 359 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

1990 • 262 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.

1985 • 234 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G Inhibition with peptide chloromethyl ketones

1977 • 224 citations

Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.

1987 • 202 citations

Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors.

1984 • 201 citations

Ultrastructural, histological, and biochemical alterations produced by 12-O-tetradecanoyl-phorbol-13-acetate on mouse epidermis and their relevance to skin tumor promotion.

1973 • 196 citations

Direct stimulation of cells expressing receptors for macrophage colony- stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1

1990 • 150 citations

The lipid binding, regulatory domain of protein kinase C. A 32-kDa fragment contains the calcium- and phosphatidylserine-dependent phorbol diester binding activity.

1986 • 140 citations

Induction of Transforming Growth Factor-α Expression in Human Keratinocytes by Phorbol Esters

1989 • 131 citations

Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells.

1986 • 121 citations

Recombinant Human Epidermal Growth Factor Precursor Is a Glycosylated Membrane Protein with Biological Activity

1989 • 111 citations

Integral membrane glycoprotein properties of the prohormone pro-transforming growth factor-α

1987 • 110 citations

Phorbol Ester or Epidermal Growth Factor (EGF) Stimulates the Concurrent Accumulation of mRNA for the EGF Receptor and Its Ligand Transforming Growth Factor-α in a Breast Cancer Cell Line

1989 • 110 citations

Characterization of high molecular weight transforming growth factor .alpha. produced by rat hepatocellular carcinoma cells

1988 • 107 citations

Detection of larger polypeptides structurally and functionally related to type I transforming growth factor.

1985 • 87 citations

Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation.

1988 • 73 citations

Ligand and Protein Kinase C Downmodulate the Colony-Stimulating Factor 1 Receptor by Independent Mechanisms

1989 • 70 citations

Structural properties of a soluble bioactive precursor for transforming growth factor-alpha.

1988 • 65 citations

Generation of transforming growth factor-alpha from the cell surface by an O-glycosylation-independent multistep process.

1990 • 61 citations

Synthesis of Membrane-Bound Colony-Stimulating Factor 1 (CSF-1) and Downmodulation of CSF-1 Receptors in NIH 3T3 Cells Transformed by Cotransfection of The Human CSF-1 and c-fms (CSF-1 Receptor) Genes

1987 • 42 citations