Tumor B Cells From Non-Hodgkin's Lymphoma Are Resistant to CD95 (Fas/Apo-1)–Mediated Apoptosis

A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]

1994 • 6,495 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

The Fas Death Factor

1995 • 4,070 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas

1995 • 462 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Fas ligation induces apoptosis of CD40-activated human B lymphocytes.

1995 • 402 citations

p53 mutation is associated with progression in follicular lymphomas

1993 • 394 citations

Rearrangement of the bcl-6 Gene as a Prognostic Marker in Diffuse Large-Cell Lymphoma

1994 • 387 citations

The role of CD40 in the regulation of humoral and cell-mediated immunity

1994 • 376 citations

Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.

1996 • 323 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma

1995 • 194 citations

APO‐1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl‐2 oncogene expression

1993 • 178 citations

Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

1996 • 169 citations

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection.

1992 • 167 citations

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

1994 • 157 citations

DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene.

1987 • 151 citations

Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells.

1995 • 129 citations

Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule.

1995 • 127 citations

Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis.

1996 • 117 citations

IL-4 induces Fas resistance in B cells.

1996 • 115 citations

Isolated follicular lymphoma cells are resistant to apoptosis and can be grown in vitro in the CD40/stromal cell system

1993 • 114 citations

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

1993 • 107 citations

A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice.

1996 • 104 citations

Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center

1996 • 99 citations

Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype

1992 • 97 citations

Predominant expression of the long isoform of Bcl‐x (Bcl‐xL) in human lymphomas

1996 • 94 citations

The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.

1991 • 91 citations

Induction of proliferation of human follicular (B type) lymphoma cells by cognate interaction with CD4+ T cell clones.

1990 • 88 citations

CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt's lymphoma B cells

1996 • 82 citations

Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas.

1994 • 69 citations

Frequent expression of FAS/APO‐1 in Hodgkin's disease and anaplastic large cell lymphomas FAS/APO‐1 in Hodgkin's disease and anaplastic large cell lymphomas

1995 • 63 citations

Malignant B lymphocytes from non‐Hodgkin's lymphoma induce allogeneic proliferative and cytotoxic T cell responses in primary mixed lymphocyte cultures: An important role of co‐stimulatory molecules CD80 (B7‐1) and CD86 (B7‐2) in stimulation by tumor cells

1995 • 46 citations

Search for Rearrangements and/or Allelic Loss of the fas/APO-1 Gene in 101 Human Lymphoma

1995 • 20 citations

Responses to T cell receptor/CD3 and interleukin-2 receptor stimulation are altered in T cells from B cell non-hodgkin's lymphomas

1995 • 14 citations