The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

National cancer institute sponsored study of classifications of non-hodgkin's lymphomas. Summary and description of a working formulation for clinical usage

1982 • 3,027 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

1988 • 814 citations

Immunoglobulin-Gene Rearrangements as Unique Clonal Markers in Human Lymphoid Neoplasms

1983 • 621 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

1987 • 473 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma.

1984 • 464 citations

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.

1988 • 432 citations

Evolutionary and Somatic Selection of the Antibody Repertoire in the Mouse

1987 • 388 citations

Chromosomal location of the genes for human immunoglobulin heavy chains.

1979 • 368 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Evolution of human immunoglobulin kappa J region genes.

1982 • 318 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

The Association of Immune Disease and Malignant Lymphoma

1967 • 288 citations

Autoimmunity in chronic lymphocytic leukaemia.

1986 • 222 citations

Biclonal B-Cell Lymphoma

1984 • 212 citations

Polymerase Chain Reaction

1988 • 207 citations

Translocation of immunoglobulin VH genes in Burkitt lymphoma.

1982 • 196 citations

The Chicken B Cell Compartment

1987 • 172 citations

Evolutionary nucleotide replacements in DNA

1979 • 169 citations

Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells

1980 • 120 citations

Single cell origin of bigenotypic and biphenotypic B cell proliferations in human follicular lymphomas.

1988 • 108 citations

Polymerase Chain Reaction

2016 • 107 citations

Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements.

1988 • 103 citations

Murine CD4+ T cell subsets defined.

1988 • 102 citations

Follicular low‐grade non‐Hodgkin's lymphoma: Long‐term outcome with or without tumor progression

1989 • 88 citations

Dispersed localization of D segments in the human immunoglobulin heavy-chain locus.

1988 • 81 citations

The management of patients with adenocarcinoma and poorly differentiated carcinoma of unknown primary site.

1989 • 80 citations

Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.

1989 • 71 citations

Single clonal origin of neoplastic B-cells with different immunoglobulin light chains in a patient with Richter's syndrome

1990 • 60 citations

Autoimmune Hemolytic Anemia and Neoplasia of the Reticuloendothelium

1968 • 60 citations

Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B cell clone

1986 • 58 citations

Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma.

1989 • 48 citations

The Influence of Somatic Mutation on Clonal Expansion

1989 • 42 citations

Immunoglobulin gene rearrangements and expression in diffuse histiocytic lymphomas reveal cellular lineage, molecular defects, and sites of chromosomal translocation

1986 • 38 citations

A rapid method for cloning and sequencing variable-region genes of expressed immunoglobulins

1987 • 38 citations

Diffuse large cell lymphoma in a patient with hairy cell leukemia: immunoglobulin gene analysis reveals separate clonal origins

1986 • 27 citations

Retention of an idiotypic determinant in a human B-cell lymphoma undergoing immunoglobulin variable-region mutation.

1987 • 25 citations

Diversity achieved by diverse mechanisms: Gene conversion in developing B cells of the chicken

1987 • 22 citations

Comparative biochemical and genetic characterization of clonally related human B-cell lines secreting pathogenic anti-Pr2 cold agglutinins

1988 • 17 citations

Prognostic significance of architectural patterns in non‐Hodgkin lymphomas

1985 • 7 citations

Diffuse large cell lymphoma in a patient with hairy cell leukemia: immunoglobulin gene analysis reveals separate clonal origins

1986 • 4 citations

Anti‐idiotypic antibodies specific for a pathologic anti‐Pr₂ cold agglutinin

1990 • 4 citations

Acquired Immunodeficiency Syndrome

1989 • 2 citations