Isolated follicular lymphoma cells are resistant to apoptosis and can be grown in vitro in the CD40/stromal cell system

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1992 • 542 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.

1989 • 349 citations

Bcl-2/JH rearrangements in benign lymphoid tissues with follicular hyperplasia.

1991 • 297 citations

Expression in Non-Hodgkin's Lymphoma of thebcl-2 Protein Associated with the t(14;18) Chromosomal Translocation

1988 • 292 citations

Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

1991 • 270 citations

CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.

1991 • 184 citations

Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII).

1987 • 150 citations

Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors

1992 • 143 citations

Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40).

1987 • 141 citations

Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. A comparison with IL-4-mediated signaling.

1988 • 136 citations

Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients.

1992 • 128 citations

Simplified procedures for applying the polymerase chain reaction to routinely fixed paraffin wax sections.

1991 • 116 citations

Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas

1992 • 98 citations

The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction.

1989 • 94 citations

Induction of proliferation of human follicular (B type) lymphoma cells by cognate interaction with CD4+ T cell clones.

1990 • 88 citations

Morphologic criteria for the differentiation of follicular lymphoma from florid reactive follicular hyperplasia: A study of 80 cases

1981 • 71 citations

Reduced apoptotic cell death in follicular lymphoma

1991 • 59 citations

Antiproliferative effects of interleukin-4 on freshly isolated non- Hodgkin malignant B-lymphoma cells

1992 • 52 citations

Interleukin 3 is a growth factor for human follicular B cell lymphoma.

1992 • 41 citations

Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene.

1988 • 40 citations

Neoplastic Changes Involving Follicles: Morphological, Immunophenotypic and Genetic Diversity of Lymphoproliferations Derived from Germinal Center and Mantle Zone

1992 • 22 citations

Rôle of cytokines in the ontogeny, activation and proliferation of B lymphocytes

1990 • 14 citations