Fas ligation induces apoptosis of CD40-activated human B lymphocytes.

The Fas Death Factor

1995 • 4,070 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Germinal Centers

1994 • 1,680 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

Negative selection of lymphocytes

1994 • 810 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

How B and T cells talk to each other

1994 • 659 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Positive selection of lymphocytes

1994 • 563 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Human Fas ligand: gene structure, chromosomal location and species specificity

1994 • 435 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

The role of CD40 in the regulation of humoral and cell-mediated immunity

1994 • 376 citations

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2

1995 • 358 citations

Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen.

1991 • 334 citations

Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones.

1991 • 333 citations

Differential ability of T_h1 and T_h2 T cells to express Fas ligand and to undergo activation-induced cell death

1994 • 329 citations

Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

1992 • 323 citations

Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

1994 • 320 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand

1993 • 260 citations

The Role of APO‐1‐Mediated Apoptosis in the Immune System

1994 • 242 citations

TCR/CD3 coupling to Fas-based cytotoxicity.

1995 • 196 citations

Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.

1994 • 182 citations

APO‐1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl‐2 oncogene expression

1993 • 178 citations

Growing human B lymphocytes in the CD40 system

1991 • 177 citations

Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes.

1993 • 145 citations

Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes

1994 • 129 citations

Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule.

1995 • 127 citations

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

1993 • 107 citations

The CD40 Antigen and Its Ligand

1994 • 82 citations

Cloned and expressed human Fc receptor for IgG mediates anti-CD3-dependent lymphoproliferation.

1988 • 80 citations

Expression of a 32‐kDa ligand for the CD40 antigen on activated human T lymphocytes

1993 • 65 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis???

1990 • 43 citations

Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes

1994 • 9 citations