Phosphorylation of Heterotrimeric G-Protein

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

‘Crosstalk’: a pivotal role for protein kinase C in modulating relationships between signal transduction pathways

1991 • 328 citations

Conjugation in Saccharomyces cerevisiae

1988 • 248 citations

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

1987 • 232 citations

Molecular basis of transmembrane signal transduction in Dictyostelium discoideum

1987 • 186 citations

Thrombin and Phorbol Esters Cause the Selective Phosphorylation of a G Protein Other Than Gi in Human Platelets

1989 • 181 citations

Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins.

1988 • 156 citations

A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets.

1988 • 138 citations

The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins G_i and G_o

1987 • 126 citations

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

1989 • 119 citations

Hormonal regulation of Gi2 α-subunit phosphorylation in intact hepatocytes

1990 • 117 citations

Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition.

1986 • 102 citations

Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles.

1988 • 99 citations

Pheromone-induced phosphorylation of a G protein β subunit in S. cerevisiae is associated with an adaptive response to mating pheromone

1991 • 96 citations

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes

1990 • 95 citations

Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein G_i

1989 • 93 citations

Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver

1986 • 84 citations

GTP-binding proteins as possible targets for protein kinase C action

1989 • 79 citations

Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity

1990 • 64 citations

Modulation of adenylate cyclase in human keratinocytes by protein kinase C.

1988 • 63 citations

In Vivo Receptor-Mediated Phosphorylation of a G Protein in Dictyostelium

1990 • 55 citations

G protein mutations that alter the pheromone response in Saccharomyces cerevisiae.

1990 • 46 citations

Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gsα) by protein kinase C

1992 • 46 citations

Effects of phosphorylation of inhibitory GTP‐binding protein by cyclic AMP‐dependent protein kinase on its ADP‐ribosylation by pertussis toxin, islet‐activating protein

1988 • 44 citations

Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2

1991 • 41 citations

Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) zucker rats: Loss of functional G1 and abnormal Gs function

1989 • 41 citations

Diabetes‐induced changes in guanine‐nucleotide‐regulatory‐protein mRNA detected using synthetic oligonucleotide probes

1990 • 41 citations

Phosphorylation of the inhibitory guanine‐nucleotide‐binding protein as a possible mechanism of inhibition by protein kinase C of agonist‐induced Ca²⁺ mobilization in human platelet

1992 • 41 citations

Thrombolamban, the 22-kDa platelet substrate of cyclic AMP-dependent protein kinase, is immunologically homologous with the Ras family of GTP-binding proteins.

1990 • 38 citations

Interaction of the human insulin receptor with the ras oncogene product p21

1987 • 38 citations

Epidermal growth factor (urogastrone)-mediated phosphorylation of a 35-kDa substrate in human placental membranes: relationship to the beta subunit of the guanine nucleotide regulatory complex.

1986 • 37 citations

Changes in the phosphorylation state of the inhibitory guanine‐nucleotide‐binding protein G_i‐2 in hepatocytes from lean (Fa/Fa) and obese (fa/fa) Zucker rats

1990 • 35 citations

G‐protein linked receptors: a family probed by molecular cloning and mutagenesis procedures

1992 • 31 citations

Gi-2 at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: The fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic states

1991 • 30 citations

G-proteins as mediators of cellular signalling processes

1991 • 28 citations

Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon

1989 • 21 citations

Insulin affects the ability of Gi to be ADP-ribosylated but does not elicit its phosphorylation in intact hepatocytes

1989 • 20 citations

The local anaesthetic benzyl alcohol attenuates the α2-adrenoceptor-mediated inhibition of human platelet adenylate cyclase activity when stimulated by prostaglandin E1, but not that stimulated by forskolin

1989 • 12 citations

Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation

1991 • 11 citations

Binding to GDP-agarose identifies a novel 60kDa substrate for the insulin receptor tyrosyl kinase in mouse NIH-3T3 cells expressing high concentrations of the human insulin receptor

1989 • 11 citations

Activation of adenylate cyclase in human platelet membranes by guanosine 5′-[βγ-imido]triphosphate is inhibited by cyclic-AMP-dependent phosphorylation. Slow activation occurs in the absence of ATP

1987 • 9 citations

Distinct functional domains on the insulin receptor β-subunit Do they provide a molecular basis for “selective” insulin resistance?

1989 • 8 citations

Insulin and Its Interaction with G Proteins

1990 • 4 citations

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