Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

1977 • 865 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

1982 • 542 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Purification of the regulatory component of adenylate cyclase.

1980 • 497 citations

Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus

1980 • 356 citations

Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

1986 • 315 citations

Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses

1979 • 315 citations

G protein multiplicity in eukaryotic signal transduction systems

1988 • 267 citations

Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands.

1984 • 242 citations

Adrenergic and serotonergic receptor binding in rat brain after chronic desmethylimipramine treatment.

1979 • 211 citations

[45] ADP-ribosylation of membrane components by pertussis and cholera toxin

1985 • 209 citations

Purification and characterization of a novel GTP-binding protein with a molecular weight of 24,000 from bovine brain membranes.

1988 • 207 citations

Charge shift electrophoresis: simple method for distinguishing between amphiphilic and hydrophilic proteins in detergent solution.

1977 • 190 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization.

1988 • 185 citations

G proteins as regulators of ion channel function

1987 • 175 citations

Regulation of the intracellular calcium level in human blood platelets: Cyclic adenosine 3′,5′-monophosphate dependent phosphorylation of a 22 000 dalton component in isolated Ca2+-accumulating vesicles

1979 • 138 citations

The development of cortical β-adrenoceptor subsensitivity in the rat by chronic treatment with trazodone, doxepin and mianserine

1978 • 138 citations

Molecular Properties of the cGMP Cascade of Vertebrate Photoreceptors

1987 • 137 citations

Electroelution of fixed and stained membrane proteins from preparative sodium dodecyl sulfate-polyacrylamide gels into a membrane trap

1986 • 130 citations

Receptor coupling to polyphosphoinositide turnover: a parallel with the adenylate cyclase system

1986 • 128 citations

Immunochemical characterization of rat brain protein kinase C.

1986 • 110 citations

Isozymes of protein kinase C in human neutrophils and their modification by two endogenous proteinases.

1990 • 106 citations

Protein kinase C alterations in the fetal rat brain after global ischemia.

1988 • 92 citations

Phosphorylation by cyclic AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding protein (smg p21) having the same putative effector domain as the ras gene products

1988 • 88 citations

GTP-binding proteins as possible targets for protein kinase C action

1989 • 79 citations

Small GTP-binding proteins

1989 • 74 citations

Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go

1987 • 69 citations

Identification of the proteolytically activated form of protein kinase C in stimulated human neutrophils.

1990 • 53 citations

The determination of molecular weights of biologically active proteins by cetyltrimethylammonium bromide-polyacrylamide gel electrophoresis

1985 • 42 citations

Interaction of Antidepressants with Brain Neurotransmitter Receptors

1981 • 40 citations

Substrate‐dependent inhibition of protein kinase C by specific inhibitors

1990 • 38 citations

Association of calpains 1 and 2 with protein kinase C activities

1987 • 23 citations

Dopamine-induced homologous and heterologous desensitizations of adenylate cyclase-coupled receptors on striatal neurons

1990 • 16 citations

Electrophysiological and receptor studies in rat brain: Effects of clorgyline

1985 • 16 citations

Proteolytic degradation of protein kinase C in the phorbol ester-induced interleukin-2 secreting thymoma cells

1988 • 11 citations

5'-p-Fluorosulfonylbenzoyl guanosine as a probe for the GTP-binding protein in alpha 2-adrenergic receptor-adenylate cyclase systems.

1983 • 8 citations

Isolation of human brain protein kinase C: Evidence for kinase C catalytic fragment modulating G protein-GTPase activity

1991 • 5 citations

Deleted Work

1955 • 0 citations