Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

1976 • 2,468 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Human Leukemic Models of Myelomonocytic Development: A Review of the HL-60 and U937 Cell Lines

1985 • 649 citations

Bacterial Endotoxins and Host Immune Responses

1980 • 629 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages.

1978 • 489 citations

Identification of a membrane-associated interleukin 1 in macrophages.

1985 • 487 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.

1985 • 308 citations

Collagenase Production by Endotoxin-Activated Macrophages

1974 • 303 citations

G protein multiplicity in eukaryotic signal transduction systems

1988 • 267 citations

Family of G protein α chains: amphipathic analysis and predicted structure of functional domains

1986 • 197 citations

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

1988 • 169 citations

Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains.

1986 • 159 citations

Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go

1988 • 153 citations

Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages.

1987 • 150 citations

Pertussis Toxin Inhibition of B Cell and Macrophage Responses to Bacterial Lipopolysaccharide

1986 • 140 citations

A role for Gi in control of thrombin receptor-phospholipase C coupling in human platelets.

1988 • 138 citations

Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.

1988 • 137 citations

Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.

1985 • 124 citations

Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.

1985 • 119 citations

Ontogeny of murine B lymphocytes: sequence of B-cell differentiation from surface-immunoglobulin-negative precursors to plasma cells.

1976 • 110 citations

Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin.

1984 • 100 citations

Detection of multiple forms of G_iαin HL60 cells

1987 • 88 citations

Human G_i protein α‐subunit: deduction of amino acid structure from a cloned cDNA

1987 • 85 citations

Subcellular localization of Gi alpha in human neutrophils.

1988 • 85 citations

The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate.

1988 • 80 citations

A small multigene family encodes Gi signal-transduction proteins.

1987 • 80 citations

Activation of distinct protein kinase C isozymes by phorbol esters: correlation with induction of interleukin 1.beta. gene expression

1989 • 73 citations

Molecular cloning of a new human G protein Evidence for two G_iα‐like protein families

1987 • 70 citations

Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines.

1988 • 63 citations

Cloning and characterization of the human gene for the α‐subunit of G_i2, a GTP‐binding signal transduction protein

1988 • 57 citations

Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides

1986 • 55 citations

Calcium ionophore (A23187) increases interleukin 1 (IL-1) production by human peripheral blood monocytes and interacts synergistically with IL-1 to augment Concanavalin A stimulated thymocyte proliferation

1985 • 43 citations

Treatment of human platelets with trypsin, thrombin, or collagen inhibits the pertussis toxin-induced ADP-ribosylation of a 41-kDa protein.

1986 • 43 citations

Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line

1988 • 36 citations

Calcium mediates one of the signals required for interleukin 1 and 2 production by murine cell lines

1984 • 31 citations

Phosphorylation substrates for protein kinase C in intact pituitary cells: characterization of a receptor-mediated event using novel gonadotropin-releasing hormone analogs

1987 • 27 citations

Lack of a central role for calcium in the induction and release of human interleukin-1

1987 • 9 citations

LPS-stimulated release of prostaglandin E and thromboxane B2 from the U937 cell line

1986 • 8 citations