The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins G_i and G_o

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

A simple method for the preparation of 32P-labelled adenosine triphosphate of high specific activity

1964 • 1,880 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Microtubules in the Cytoplasm of an Amoeba

1969 • 340 citations

Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

1986 • 315 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Purification of insulin receptor with full binding activity.

1983 • 273 citations

Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.

1985 • 205 citations

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 • 203 citations

Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta.

1984 • 201 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes

1983 • 156 citations

The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase.

1985 • 140 citations

Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin.

1984 • 100 citations

Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase

1983 • 97 citations

Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes

1985 • 84 citations

Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver

1986 • 84 citations

Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function.

1986 • 76 citations

The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes

1986 • 69 citations

Insulin: in search of a mechanism

1983 • 45 citations

Selective regulation by pertussis toxin of insulin-induced activation of particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes

1983 • 41 citations

Membrane phosphorylation: a crucial role in the action of insulin, EGF, and pp60src?

1981 • 41 citations

Cell signalling: Dual control of adenylate cyclase

1983 • 32 citations

Immunoaffinity purification of insulin receptor by use of monclonal antibodies

1986 • 6 citations

Monoclonal antibodies for the human insulin receptor stimulate intrinsic receptor-kinase activity

1986 • 2 citations