Collagen induced MMP-2 activation in human breast cancer

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Basement membrane complexes with biological activity

1986 • 1,489 citations

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

1986 • 1,408 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Diagnostic Histopathology of the Breast

1988 • 1,083 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Tumor invasion and the extracellular matrix.

1983 • 960 citations

Molecular Biology of the Cell

1990 • 951 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis.

1993 • 658 citations

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1992 • 530 citations

Type IV collagenases in tumor invasion and metastasis

1990 • 502 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations.

1991 • 447 citations

Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion.

1993 • 428 citations

Molecular biology of the cell (2nd edn)

1989 • 424 citations

Role of the alpha v beta 3 integrin in human melanoma cell invasion.

1992 • 414 citations

Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.

1991 • 401 citations

Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma.

1993 • 398 citations

Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.

1993 • 394 citations

Cell Biology of Extracellular Matrix

1991 • 386 citations

Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells

1991 • 379 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Role of collagenases in tumor cell invasion

1982 • 340 citations

Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2

1993 • 338 citations

Activity of type IV collagenases in benign and malignant breast disease

1993 • 337 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites

1992 • 326 citations

Tumor Cell Invasion Inhibited by TIMP-2

1991 • 324 citations

Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue.

1990 • 323 citations

Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials.

1987 • 315 citations

Cancer Metastasis: Experimental Approaches, Theoretical Concepts, and Impacts for Treatment Strategies

1985 • 301 citations

Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.

1991 • 282 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Differentiation state and invasiveness of human breast cancer cell lines

1994 • 260 citations

Type IV collagenases in invasive tumors

1993 • 256 citations

Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1.

1993 • 253 citations

Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

1990 • 235 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Analysis of alpha 1 beta 1, alpha 2 beta 1 and alpha 3 beta 1 integrins in cell--collagen interactions: identification of conformation dependent alpha 1 beta 1 binding sites in collagen type I.

1992 • 218 citations

Association of MMP-2 Activation Potential With Metastatic Progression in Human Breast Cancer Cell Lines Independent of MMP-2 Production

1993 • 216 citations

Basement Membrane and the Invasive Activity of Metastatic Tumor Cells

1986 • 209 citations

Augmentation of type IV collagenase, laminin receptor, and Ki67 proliferation antigen associated with human colon, gastric, and breast carcinoma progression.

1991 • 207 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes

1991 • 201 citations

Epithelial (E‐) and placentae (P‐) cadherin cell adhesion molecule expression in breast carcinoma

1993 • 200 citations

In vitro model of angiogenesis using a human endothelium‐derived permanent cell line: Contributions of induced gene expression, G‐proteins, and integrins

1992 • 198 citations

Integrin expression in human melanoma cells with differing invasive and metastatic properties

1992 • 197 citations

Binding and localization of M(r) 72,000 matrix metalloproteinase at cell surface invadopodia.

1993 • 182 citations

Type IV collagenase (M(r) 72,000) expression in human prostate: benign and malignant tissue.

1993 • 181 citations

Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.

1992 • 166 citations

Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells.

1989 • 163 citations

Multiple integrins share the ability to induce elevation of intracellular pH*1

1991 • 161 citations

Degradation of Basement Membrane by Murine Tumor Cells2

1977 • 156 citations

Collagen-induced activation of the M(r) 72,000 type IV collagenase in normal and malignant human fibroblastoid cells.

1992 • 154 citations

Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase.

1992 • 153 citations

Tumor cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, invasion and metastasis

1992 • 150 citations

Signaling by integrins: implications for tumorigenesis.

1993 • 150 citations

The 72 kDa type IV collagenase is modulated via differential expression of alpha v beta 3 and alpha 5 beta 1 integrins during human melanoma cell invasion.

1993 • 147 citations

Expression of Collagenase IV (Basement Membrane Collagenase) Activity in Murine Tumor Cell Hybrids That Differ in Metastatic Potential<xref ref-type="fn" rid="FN2">2</xref>

1985 • 145 citations

New Aspects of Stroma-Parenchyma Relations in Mammary Gland Differentiation

1991 • 140 citations

Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex

1993 • 138 citations

Immunohistochemical localization of matrix metallloproteinase 2 and its specific inhibitor timp‐2 in neoplastic tissues with monclonal antibodies

1994 • 137 citations

The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen.

1990 • 137 citations

Expression of activated gelatinase in human invasive breast carcinoma

1993 • 135 citations

Regulation of alpha 2 beta 1-mediated fibroblast migration on type I collagen by shifts in the concentrations of extracellular Mg2+ and Ca2+ [published erratum appears in J Cell Biol 1992 Jul;118(1):219]

1992 • 134 citations

Changes in multiple or sequential estrogen receptor determinations in breast cancer

1980 • 132 citations

Mechanisms of Growth Control in Normal and Malignant Breast Epithelium

1989 • 131 citations

Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy.

1992 • 129 citations

Induction of macrophage metalloproteinases by extracellular matrix. Evidence for enzyme- and substrate-specific responses involving prostaglandin-dependent mechanisms.

1993 • 128 citations

Ras-responsive genes and tumor metastasis.

1993 • 127 citations

Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor.

1990 • 126 citations

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-basedin vitro assays

1993 • 122 citations

Characterization of glomerular epithelial cell matrix receptors.

1992 • 120 citations

Vimentin—a new prognostic parameter in breast carcinoma?

1989 • 117 citations

Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology.

1993 • 115 citations

Vimentin is preferentially expressed in human breast carcinomas with low estrogen receptor and high Ki-67 growth fraction.

1990 • 111 citations

Extracellular matrix-stimulated phospholipase activation is mediated by beta 1-integrin

1993 • 109 citations

Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells

1992 • 105 citations

Evaluation of Basement Membrane Components and the 72 kDa Type IV Collagenase in Serous Tumors of the Ovary

1992 • 105 citations

Co‐expression of cytokeratin and vimentin intermediate filament proteins in benign and neoplastic breast epithelium

1989 • 93 citations

Vimentin and p53 expression on epidermal growth factor receptor-positive, oestrogen receptor-negative breast carcinomas

1988 • 92 citations

Laminin receptors, collagenase IV and prognosis in node‐negative breast cancers

1991 • 91 citations

Increased invasion and spontaneous metastasis of BL6 melanoma with inhibition of the desmoplastic response in C57 BL/6 mice.

1987 • 86 citations

Oncogene-induced basement membrane invasiveness in human mammary epithelial cells

1994 • 83 citations

Invasion and metastasis

1992 • 83 citations

Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v.

1990 • 80 citations

Human gelatinase/type IV procollagenase is a regular plasma component

1989 • 79 citations

Different β1-integrin collagen receptors on rat hepatocytes and cardiac fibroblasts

1990 • 79 citations

Modulation of type‐iv collagenase activity and invasive behavior of metastatic human melanoma (A2058) cells in vitro by monoclonal antibodies to type‐iv collagenase

1990 • 76 citations

Collagen-induced rapid morphogenesis of human mammary epithelial cells: The role of the α 2 β 1 integrin

1992 • 75 citations

Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels

1985 • 75 citations

Vimentin is preferentially expressed in high-grade ductal and medullary, but not in lobular breast carcinomas.

1990 • 71 citations

Desmoplastic breast carcinoma as a source of human myofibroblasts.

1984 • 68 citations

Smooth muscle differentiation in cultured human breast gland stromal cells.

1990 • 67 citations

Migration of a Human Keratinocyte Cell Line (HACAT) to Interstitial Collagen Type I Is Mediated by the α2β1-Integrin Receptor

1992 • 67 citations

Immunolocalization of matrix metallo-proteinases and their tissue inhibitor in human mammary pathology.

1992 • 63 citations

Inhibition of fibronectin binding and fibronectin-mediated cell adhesion to collagen by a peptide from the second type I repeat of thrombospondin.

1993 • 62 citations

Constitutive Synthesis of a 92-kDa Keratinocyte-Derived Type IV Collagenase Is Enhanced by Type I Collagen and Decreased by Type IV Collagen Matrices

1992 • 61 citations

Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein.

1993 • 61 citations

Adhesion of Human Neutrophils to and Activation by Type-I Collagen Involving a β2 Integrin

1991 • 60 citations

Hormonal carcinogenesis in breast cancer: cellular and molecular studies of malignant progression

1994 • 60 citations

Stromal cell changes in human colorectal adenomas and carcinomas

1983 • 60 citations

Possible involvement of Ca2+ mobilization and protein kinase C activation in the induction of spontaneous metastasis by mouse mammary adenocarcinoma cells.

1989 • 60 citations

Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene

1988 • 59 citations

Immunohistochemical profile of basement membrane proteins and 72 kilodalton type IV collagenase in the implantation placental site. An integrated view.

1992 • 58 citations

Elastosis and other stromal reactions in benign and malignant breast tissue.An ultrastructural study

1977 • 56 citations

A comparison of spreading and motility behaviour of 8701 -BC breast carcinoma cells on type I, I-trimer and type V collagen substrata evidence for a permissive effect of type I-trimer collagen on cell locomotion

1991 • 49 citations

Identification of type I collagen-producing cells in human gastrointestinal carcinomas by non-radioactive in situ hybridization and immunoelectron microscopy.

1992 • 47 citations

Hypothesis: Persistent Expression of Fetal Phenotypic Characteristics by Fibroblasts Is Associated with an Increased Susceptibility to Neoplastic Disease

1987 • 47 citations

Blocking of collagenase secretion by estramustine during in vitro tumor cell invasion.

1988 • 47 citations

G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.

1989 • 42 citations

A new form of tumor and fetal collagen that binds laminin

1993 • 41 citations

Influences of extracellular matrix components on the growth and differentiation of ruminal epithelial cells in primary culture

1993 • 39 citations

Modulation of collagen and fibronectin synthesis in fibroblasts by normal and malignant cells

1992 • 38 citations

Adhesion and activation of human neutrophils on basement membrane molecules

1993 • 33 citations

Quantitative determination of collagen types present in the ductal infiltrating carcinoma of human mammary gland

1985 • 33 citations

Collagen and Elastin Synthesis in Human Stroma and Breast Carcinoma Cell Lines: Modulation by the Extracellular Matrix

1986 • 32 citations

Stromal-epithelial interactions in breast cancer

1991 • 31 citations

Assays for the study of human cancer cell invasion and metastasis

1992 • 30 citations

Neuritogenesis on collagen substrates. Involvement of integrin‐like matrix receptors in retinal fibre outgrowth on collagen

1992 • 30 citations

Collagen production by macrophages in tumour encapsulation and dormancy

1991 • 29 citations

Inhibition of Tumor Cell Invasion by Verapamil

1991 • 28 citations

Different mechanisms of extracellular matrix remodeling by fibroblasts in response to human mammary neoplastic cells.

1993 • 26 citations

Type I collagen substrate increases calcitonin and parathyroid hormone receptor‐mediated signal transduction in UMR 106–06 osteoblast‐like cells

1993 • 26 citations

Disassembly of F-actin filaments in human endothelial cells cultured on type V collagen

1992 • 26 citations

Intracellular localization of types i and ii collagen mrna and endoplasmic reticulum in embryonic corneal epithelia

1991 • 26 citations

The spread of human lung cancer cells on collagens and its inhibition by type III collagen

1991 • 25 citations

Modulators of intracellular Ca2+ and the calmodulin inhibitor W-7 alter the expression of metastasis-associated genes MTS1 and NM23 in metastatic variants of the B16 murine melanoma

1992 • 25 citations

Collagen biosynthesis by a breast carcinoma cell strain and biopsy fragments of the primary tumour

1988 • 22 citations

Collagen composition in the ductal infiltrating carcinoma of human breast

1984 • 22 citations

Tumor Necrosis Factor-α Increased the Integrin α2β1 Expression and Cell Attachment to Type I Collagen in Human Dermal Fibroblasts

1993 • 20 citations

Modulation of human mesangial cell behaviour by extracellular matrix components—the possible role of interstitial type III collagen

1993 • 19 citations

The Stimulation of Fibroblasts Collagen Synthesis by Neoplastic Cells is Modulated by the Extracellular Matrix

1992 • 18 citations

Differential expression of type I collagen and cellular fibronectin isoforms in endothelial cell variants

1993 • 17 citations

Desmoplasia in Benign and Malignant Breast Disease is Characterized by Alterations in Level of mRNAs Coding for Types I and III Procollagen

1991 • 15 citations

Growth Dynamics of Cultured Myofibroblasts from Human Breast Cancer and Nonmalignant Contracting Tissues

1984 • 14 citations

Detection by in situ hybridization of messenger RNAs of collagen types I and IV in murine mammary cancer

1989 • 12 citations

Distribution of the major connective matrix components of the stromal reaction in breast carcinoma. An immunohistochemical study.

1987 • 12 citations

Possible mechanisms of type I collagen-induced vascular tube formation

1992 • 9 citations

[Expression of type I and type III procollagen genes in human scirrhous carcinoma of breast by in situ hybridization].

1992 • 6 citations

Correlation between secretion pattern and metastatic potential from drug-treated 3LL tumor cell line.

1991 • 3 citations

Phenotypic responses of mouse mammary tumours and normal mammary epithelium cultured in collagen gels: Correlation with tumour type and progression

1992 • 2 citations

[Activation of polymorphonuclear neutrophils by contact with collagen I and degradation of collagen].

1991 • 1 citations

[Synthesis and supramolecular organization of components of the extracellular matrix by fibroblasts cultured in a collagen lattice].

1992 • 1 citations

[Localization of type I, III, IV collagen and fibronectin in benign tumors and epitheliomas of the human breast].

1984 • 1 citations