G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Selection of Successive Tumour Lines for Metastasis

1973 • 1,360 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Flow of information in the light-triggered cyclic nucleotide cascade of vision.

1981 • 740 citations

BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE

1986 • 693 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Signal transduction by guanine nucleotide binding proteins

1987 • 362 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

1987 • 356 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

The α Subunit of the GTP Binding Protein G _k Opens Atrial Potassium Channels

1987 • 317 citations

Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

1986 • 315 citations

Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro.

1984 • 314 citations

Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells. Reconstitution with Gi or Go of the plasma membranes ADP-ribosylated by pertussis toxin.

1986 • 276 citations

Human fibronectin contains distinct adhesion- and motility-promoting domains for metastatic melanoma cells.

1986 • 270 citations

Differential effects of laminin, intact type IV collagen, and specific domains of type IV collagen on endothelial cell adhesion and migration.

1988 • 237 citations

Mechanisms of action of calcium‐mobilizing agonists: some variations on a young theme

1988 • 236 citations

The role of cell adhesion proteins?laminin and fibronectin?in the movement of malignant and metastatic cells

1985 • 236 citations

Chemoattractant Receptors on Phagocytic Cells

1984 • 236 citations

Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.

1985 • 192 citations

Evidence for involvement of guanine nucleotide‐binding regulatory proteins in the activation of phospholipases by hormones

1988 • 190 citations

Inhibition of lymphocyte and neutrophil chemotaxis by pertussis toxin.

1985 • 189 citations

Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.

1987 • 186 citations

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

1988 • 169 citations

Invasion of reconstituted basement membrane matrix by metastatic human tumor cells.

1986 • 160 citations

Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go

1988 • 153 citations

Modulating Influence of Chemotactic Factor-Induced Cell Adhesiveness on Granulocyte Function

1979 • 151 citations

Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.

1986 • 148 citations

Experimental systems for analysis of the malignant phenotype

1982 • 116 citations

Purification and immunochemical characterization of the major pertussis‐toxin‐sensitive guanine‐nucleotide‐binding protein of bovine‐neutrophil membranes

1987 • 110 citations

Comparison of the metastatic properties of B16 melanoma clones isolated from cultured cell lines, subcutaneous tumors, and individual lung metastases.

1982 • 106 citations

Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells

1987 • 97 citations

Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clones

1984 • 56 citations

Turnover of adenosine 3',5'-monophosphate in WI-38 cultured fibroblasts

1980 • 46 citations

Inhibition of lymphoma invasion and liver metastasis formation by pertussis toxin.

1987 • 40 citations

Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties

1986 • 25 citations

Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc− membranes

1987 • 9 citations